A5082564867- Alzheimer's disease research and treatments
- Polyomavirus and related diseases
- Epilepsy research and treatment
- Autoimmune Neurological Disorders and Treatments
- Herpesvirus Infections and Treatments
- Diet and metabolism studies
- Peripheral Neuropathies and Disorders
- Tuberous Sclerosis Complex Research
- Genetic and rare skin diseases.
- Metabolism and Genetic Disorders
- Electrolyte and hormonal disorders
- Anesthesia and Sedative Agents
- Functional Brain Connectivity Studies
- Diet, Metabolism, and Disease
- Advanced Algebra and Geometry
- Intestinal Malrotation and Obstruction Disorders
- Genetic and Kidney Cyst Diseases
- Fetal and Pediatric Neurological Disorders
- Neurological disorders and treatments
- RNA and protein synthesis mechanisms
- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Memory and Neural Mechanisms
- Neurological and metabolic disorders
- Botulinum Toxin and Related Neurological Disorders
Texas Children's Hospital
2018-2024
Baylor College of Medicine
2018-2024
Child Neurology Associates
2019
University of Minnesota
2010-2019
Berman Center for Outcomes and Clinical Research
2011-2019
University of Minnesota Medical Center
2010
To improve the ability to develop treatments that prevent incipient Alzheimer disease (AD) from progressing overt AD, it is important understand molecular basis of earliest pathophysiological abnormalities and determine how amyloid-β (Aβ) involved very early in its pathogenesis.To investigate 2 specific Aβ oligomers, trimers Aβ*56, human cerebrospinal fluid (CSF); evaluate effects aging AD; obtain support for hypothesis they may be pathogenic by determining their relationships CSF tau.A...
In a previous study, we reported that levels of two types protein species—a type ~55-kDa species and ~15-kDa species—are elevated in the lumbar cerebrospinal fluid (CSF) cognitively intact elderly individuals who are at risk for Alzheimer's disease (AD). These immunoreactive to monoclonal antibody 6E10, which is directed against amino acids 6–10 amyloid-β (Aβ), their correlate with total tau phosphorylated Thr181. this investigated molecular composition these AD-related proteins using...
Background Ketogenic diet is an effective therapy for patients with medically refractory epilepsy. It generally well tolerated, the most common side effects being gastrointestinal. Hepatic toxicity has been described as uncommon effect of ketogenic diet, usually long-term use. However, there are limited data to implicate in acute liver toxicity. Methods and results We analyzed all who underwent elective inpatient initiation at our institution from June 2019 2022. Of 25 reviewed, we found 6...
BACKGROUND: Surgery has become integral in treating children with tuberous sclerosis complex (TSC)–related drug-resistant epilepsy (DRE). OBJECTIVE: To describe outcomes of a multimodal diagnostic and therapeutic approach comprising invasive intracranial monitoring surgical treatment compare the complementary techniques open resection magnetic resonance–guided laser interstitial thermal therapy. METHODS: Clinical radiographic data were prospectively collected for pediatric patients...
In carefully selected patients with medically refractory epilepsy, disconnective hemispherotomy can result in significant seizure freedom; however, incomplete disconnection ongoing seizures and poses a challenge. Completion provides an opportunity to finish the disconnection. We describe use of magnetic resonance-guided laser interstitial thermal ablation (MRgLITT) for completion hemispherotomy.Patients treated using MRgLITT at our institution were identified. Procedural outcomes evaluated...
To describe a series of patients with CblC varying ages symptom onset, diagnosis, and initiation treatment, highlighting the importance expanded NBS in early diagnosis treatment children CblC.
A growing body of evidence has led to the identification a preclinical phase Alzheimer's disease (AD) wherein pathological processes occur prior cognitive symptoms. Several potential biomarkers AD have been described, and preliminary longitudinal studies suggest that AD-like biomarker profiles may predict future decline in asymptomatic elderly individuals. The amyloid cascade hypothesis initially posited originates with Amyloid-ß (Aß) plaques, but recent advances instead implicate soluble Aß...
Soluble oligomeric forms of the Aβ protein, such as dimers, trimers, and putative dodecamers, have been implicated in development Alzheimer's disease (AD). However, specific roles these distinct species remain elusive. A major obstacle addressing this question is lack reagents that bind specifically to each species. Aptamers are single stranded oligonucleotide molecules can be selected target molecules, comparable affinity monoclonal antibodies. We attempted develop DNA aptamers trimeric...
May 5, 2019April 9, 2019Free AccessRecurrent mosaic MTOR c.5930C>T (p.Thr1977Ile) Variant Causing Megalencephaly, Asymmetric Polymicrogyria, and Cutaneous Pigmentary Mosaicism (P1.6-037)Maureen Handoko, Lisa Emrick, Jill Rosenfeld, Xia Wang, Alyssa Tran, Alicia Turner, John Belmont, Brendan Lee, Carlos Bacino, Hsiao-Tuan ChaoAuthors Info & AffiliationsApril 2019 issue92 (15_supplement)https://doi.org/10.1212/WNL.92.15_supplement.P1.6-037 Letters to the Editor