A5023715620- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Muscle Physiology and Disorders
- Exercise and Physiological Responses
- Bee Products Chemical Analysis
- Tendon Structure and Treatment
- Tissue Engineering and Regenerative Medicine
- Sports injuries and prevention
- Cardiac Ischemia and Reperfusion
- Muscle metabolism and nutrition
- Autophagy in Disease and Therapy
- Neurogenetic and Muscular Disorders Research
- Bioactive Compounds in Plants
- Myofascial pain diagnosis and treatment
- Neurological Disease Mechanisms and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Sirtuins and Resveratrol in Medicine
- Takotsubo Cardiomyopathy and Associated Phenomena
- Virus-based gene therapy research
- Dietary Effects on Health
- MicroRNA in disease regulation
- Bone Tissue Engineering Materials
- Transplantation: Methods and Outcomes
- CRISPR and Genetic Engineering
- Cardiac Imaging and Diagnostics
Institute of Molecular Biology, Academia Sinica
2025
Academia Sinica
2025
University of Illinois Urbana-Champaign
2017-2022
Guangxi University of Chinese Medicine
2020
Guangxi Zhuang Autonomous Region Brain Hospital
2019
National Taiwan University
2017
The People's Hospital of LinXia
2011
Abstract Diabetes mellitus (DM) is associated with higher risk of tendinopathy, which reduces tolerance to exercise and functional activities affects lifestyle glycemic control. Expression tendon-related genes matrix metabolism in tenocytes are essential for maintaining physiological functions tendon. However, the molecular mechanisms involved diabetic tendinopathy remain unclear. We hypothesized that high glucose (HG) alters characteristics tenocyte. Using vitro 2-week culture tenocytes, we...
Stem cell transplantation has been a promising treatment for peripheral arterial diseases in the past decade. cells act as living bioreactors of paracrine factors that orchestrate tissue regeneration. Prestimulated adipose-derived stem (ADSCs) have proposed potential candidates but met with challenges activating their secretory activities clinical use. Here, we propose tethering ADSC surface nanoparticles releasing tumor necrosis factor α (TNFα), named nanostimulator, would stimulate...
Extended periods of bed rest and limb immobilization are required for healing post-injury or disease, yet disuse can result in significant muscle atrophy decreased quality life older adults. Physical rehabilitation is commonly prescribed to recover these deficits, accumulation reactive oxygen species sustained rates protein degradation persist during the period that significantly delay prevent recovery. Pericytes, considered primary mesenchymal vascular stromal cell skeletal muscle, secrete...
Objective: Coronary microembolization (CME)-induced cardiomyocyte apoptosis is the primary factor in causing cardiac dysfunction. Resveratrol (RES) known to play a protective role variety of cardiovascular diseases, yet it not whether RES has CME. Therefore, effect on and function damage which are induced by CME rats was investigated this study. Methods: Fifty Sprague-Dawley were separated into 5 groups randomly (10 included each): sham group, RES+CME RES+CME+Sirtuin-1 (SIRT-1) inhibitor...
<b><i>Background:</i></b> Coronary microembolisation (CME)-induced myocardial apoptosis is a key factor in progressive cardiac dysfunction. Aloperine (ALO) plays protective role the cardiovascular system, but its and mechanism underlying protection against CME are unclear. Therefore, we aimed to verify whether ALO has effect CME-induced injury, as well this relationship with regulation of PI3K/Akt pathway for rats. <b><i>Methods:</i></b> Forty...
Diabetes mellitus is associated with damage to tendons, which may result from cellular dysfunction in response a hyperglycemic environment. Tenocytes express diminished levels of tendon-associated genes under conditions. In contrast, mechanical stretch enhances tenogenic differentiation. However, whether hyperglycemia increases the non-tenogenic differentiation potential tenocytes and this can be mitigated by remains elusive. We explored vitro effects high glucose on rat primary tenocytes....
Purpose Mechanical stimuli are essential for the maintenance of tendon tissue homeostasis. The study aims to elucidate mechanobiological mechanisms underlying tenocyte homeostasis by cyclic mechanical stretch under high-glucose (HG) condition.Materials and methods Primary tenocytes were isolated from rat Achilles 2D-cultured HG condition. in vitro effects a single bout, 2-h biaxial session (1 Hz, 8%) on primary explored through Flexcell system. Cell viability, tenogenic gene expression,...
Extended bed rest or limb immobilization can significantly reduce skeletal muscle mass and function. Recovery may be incomplete, particularly in older adults. Our laboratory recently reported that vascular mural cell (pericyte) quantity is compromised after appropriate replacement immediately before remobilization effectively recover myofiber size mice. Identification of a single surface marker for isolation the most therapeutic pericyte would streamline efforts to optimize recovery. The...
Abstract Anabolic resistance to a mechanical stimulus may contribute the loss of skeletal muscle mass observed with age. In this study, young and aged mice were injected saline or human LM-111 (1 mg/kg). One week later, myotendinous junction gastrocnemius was removed via myotenectomy (MTE), thus placing chronic on remaining plantaris for 2 weeks. increased α7B integrin protein expression clustering near DAPI+ nuclei in response MTE. reduced CD11b+ immune cells, enhanced repair, improved...
ABSTRACT Purpose Recently, it has been suggested that a cellular pathway composed of integrin, integrin-linked kinase (ILK), rapamycin-insensitive companion mTOR (RICTOR), and Akt may facilitate long-term structural functional adaptations associated with exercise, independent the mTORC1 pathway. Therefore, we examined changes in integrin–ILK–RICTOR–Akt protein vastus lateralis (VL) before after 8 wk eccentric cycling training (ECC), which was expected to increase muscle function VL...
Our laboratory recently reported a significant decline in muscle-resident pericyte quantity following hindlimb immobilization, and subsequently demonstrated the capacity for transplantation to accelerate recovery of skeletal muscle mass during rehabilitation period. PURPOSE: The purpose this study was determine extent which pericyte-derived extracellular vesicles (EVs) effectively recover immobilization. METHODS: Two groups donor mice (n=6/group) were used isolate serum EVs before (“Pre”)...
Significant loss in skeletal muscle mass and function can occur after periods of extended bed rest or immobilization. Physical therapy is recommended, but recovery may be incomplete special populations due to injury functional limitations. Our lab recently demonstrated the capacity for pericytes, vascular stromal cells, accelerate following disuse a mouse model. Different pericyte exist based on localization unique cell surface markers, yet most therapeutic population has not been...