A5100334304- Metal complexes synthesis and properties
- DNA and Nucleic Acid Chemistry
- Cancer Immunotherapy and Biomarkers
- Metal-Organic Frameworks: Synthesis and Applications
- Immunotherapy and Immune Responses
- Colorectal Cancer Treatments and Studies
- Curcumin's Biomedical Applications
- Computational Drug Discovery Methods
- Pesticide and Herbicide Environmental Studies
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Synthesis and biological activity
- Pharmacovigilance and Adverse Drug Reactions
- Geology and Paleoclimatology Research
- Polyoxometalates: Synthesis and Applications
- Genomics, phytochemicals, and oxidative stress
- Circular RNAs in diseases
- Inflammatory Biomarkers in Disease Prognosis
- Colorectal Cancer Screening and Detection
- Adipokines, Inflammation, and Metabolic Diseases
- Surfactants and Colloidal Systems
- Isotope Analysis in Ecology
- Pacific and Southeast Asian Studies
- Click Chemistry and Applications
- Metal-Catalyzed Oxygenation Mechanisms
Nanchang University
2024
Tianjin Medical University General Hospital
2024
Sichuan University of Science and Engineering
2017-2023
East China Normal University
2022
University of Michigan
2022
Shanghai Zhabei District Shibei Hospital
2021
Yueyang Hospital
2021
Shanghai University of Traditional Chinese Medicine
2021
Jingzhou Central Hospital
2021
Liaoning University of Traditional Chinese Medicine
2021
Background Neutrophil to lymphocyte ratio (NLR) was reported be an independent easy‐to‐measure marker for many diseases, while the distribution of NLR in healthy population not formally studied. So we investigated people this study. Methods Data include NLR, systolic pressure, diastolic and body mass index (BMI), which were collected from 3,262 population. Correlations with variables analyzed SPSS16.0. Results demonstrated that positively associated age ( P < 0.001). The eldest group...
Abstract Background The blocking of the programmed cell death protein (PD-1)/programmed death-ligand 1 (PD-L1) axis has been found to have an anticancer activity against various types cancer by enhancing T immunity, while there are no studies linking PD-1/PD-L1 chemotherapy drugs in osteosarcoma (OS). present study aimed investigate effects on cisplatin OS vitro and vivo. Methods Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was applied detect PD-L1 mRNA tissues....
Highlights•Sag deletion causes the conversion of pancreatic mPanINs to neoplastic cystic lesions•Shoc2 significantly inhibits growth pancreas and formation mPanINs•SAG is an E3 ligase that promotes SHOC2 ubiquitylation degradation•The Sag-Shoc2 axis specifies tumor types via modulating pMapk/mTorc1 signalsSummarySAG/RBX2 ligase, whereas a RAS-RAF positive regulator. In this study, we address how crosstalk regulates tumorigenesis induced by KrasG12D. Sag increases size murine intraepithelial...
The Luo-hua-zi-zhu (LHZZ) granule has been widely used for the treatment of colorectal adenoma (CRA), which is a precursor cancer (CRC). However, active components LUZZ and its mechanism action against CRA have not yet elucidated. This study was designed to investigate effect LHZZ on explore pharmacological mechanisms. First, total 24 chemical constituents were identified in 50% aqueous methanol extract based mass fragment patterns spectral library using high resolution UPLC-Q-TOF MS/MS...
Three novel binuclear copper(<sc>ii</sc>) complexes with reduced <sc>l</sc>-serine Schiff bases exhibited significant activity differences for the hydrolysis of PNPA and PNPP, suggesting a favourable intramolecular nucleophilic pathway PNPP.
Purpose As a usual malignant tumor in urinary system, renal cell cancer is regulated by microRNAs (miRNAs). This study revealed the prognostic value and regulatory effect of miR-190a-5p patients. Methods A total 253 patients were included for analysis. The target gene was detected luciferase reporter assay. Cell Counting Kit-8 analysis Transwell performed to explore proliferation, removal capability, invasiveness 786–0 A498 cells. Prognostic calculated Kaplan–Meier curve Cox regression...
Oxidative cleavage of phosphate diesters (HPNP, BNPP) is highly faster than the hydrolytic one by binuclear metal complexes with novel imidazole derivative, producing a non-lactone monoester due to direct attack free radicals.
Background: Canmei formula (CMF) is a traditional Chinese medicine compound with definite effect on the prevention and treatment of colorectal adenoma (CRA). CMF can prevent transformation intestinal inflammation to cancer. This study explored mechanism action in anti-CRA using multi-omics techniques. Method: The mice were randomly divided into four groups: blank group (Control), high-fat diet (HFD) + AOM/DSS model (ADH) groups, (ADH-CMF) sulfasalazine (Sul). Except for group, ADH was...
To screen and identify molecular targets bacteria genus leading to adenomatous polyps in mouse induced by high-fat diet (HFD) +AOM/DSS using omics technology.The of colorectal adenoma disease were obtained from the GeneCards OMIM database. The SPF C57BL mice randomly divided into blank (Control) AOM/DSS+HFD model (ADH) groups. ADH group was intraperitoneally injected with AOM reagent. Then, given 2.5% DSS (in free drinking water) establish model. During this period, changes physical signs...
Curcumin is a potential drug for the treatment of colorectal cancer (CRC). Its mechanism action has not been elucidated. This study aims to investigate curcumin in CRC via bioinformatics methods such as network pharmacology and molecular docking.The targets were obtained from public databases. The component-targets was constructed by Cytoscape v3.7.2. Through protein-protein interaction (PPI), Gene Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG), important signaling pathways related...
Background Circulating tumor cells (CTCs) and markers (TMs) are two kinds of diagnostic prognostic for lung cancer. CTCs detect cells, while TMs molecules in peripheral blood. This study aimed to investigate which marker is a better choice the diagnosis prognostication Methods The values were compared by generating receiver operating characteristic (ROC) curves performing logistic regression analyses. Kaplan-Meier CTCs, TMs, clinical characteristics. Results ROC curve analysis showed that...
Abstract Purpose To construct a molecular subtype based on immunotherapy response in renal clear cell carcinoma (ccRCC) and explore the regulatory mechanisms of immune microenvironment between subtype. Methods RNA-seq data related to checkpoint blockade (ICB) therapy for ccRCC-related from GSE67501 dataset clinical information were collected GEO TCGA datasets. Differentially expressed genes (DEGs) identified using 'limma' R package. GO KEGG pathways analysis DEGs performed 'clusterProfiler'...
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Objective This study was designed to conduct data mining through the Food and Drug Administration Adverse Event Reporting System (FAERS) assess adverse events (AEs) associated with cabozantinib in treatment of renal cell carcinoma.
Abstract Background: Curcumin is a potential drug for the treatment of colorectal cancer (CRC). Its mechanism action has not been elucidated. Aim: To investigate curcumin in CRC via network pharmacology, molecular docking and experimental verification. Methods: The targets were obtained from public databases. component-targets was constructed by Cytoscape v3.7.2. Through protein-protein interaction (PPI), Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG), important signaling...