A5101873640- Traditional Chinese Medicine Analysis
- Neurological Disease Mechanisms and Treatments
- Plant-based Medicinal Research
- Traditional Chinese Medicine Studies
- Biological and pharmacological studies of plants
- Metabolomics and Mass Spectrometry Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Flavonoids in Medical Research
- Healthcare and Venom Research
- Drug Transport and Resistance Mechanisms
- Medicinal Plant Pharmacodynamics Research
- Cardiac Ischemia and Reperfusion
- Chromatography in Natural Products
- Intracerebral and Subarachnoid Hemorrhage Research
- Mitochondrial Function and Pathology
- Lipid metabolism and disorders
- Electron Spin Resonance Studies
- Ferroptosis and cancer prognosis
- Acute Ischemic Stroke Management
- Organometallic Complex Synthesis and Catalysis
- Ziziphus Jujuba Studies and Applications
- Microbial Metabolism and Applications
- Cardiac electrophysiology and arrhythmias
Zhejiang Chinese Medical University
2016-2025
First Affiliated Hospital of Henan University
2025
XinHua Hospital
2015
Zhejiang Wanli University
2012
Yueqing People's Hospital
2011
Zhejiang University
2007
Danhong injection (DHI) is a compound Chinese medicine widely used in China for treatment of ischemic cardio-cerebrovascular diseases. However, limited data are available regarding the protective effect DHI on penumbra stroke. This study aimed to investigate intravenous neuronal injure after cerebral ischemia/reperfusion (CI/R), focusing especially involvement intracellular energy metabolism coupling. Male Sprague-Dawley rats were subjected right middle artery occlusion 60 min followed by...
Salvianolic acid C (SAC) is a major bioactive component of Salvia miltiorrhiza Bunge (Danshen), Chinese herb for treating ischemic stroke (IS). However, the mechanism by which SAC affects IS has not yet been evaluated, thus network pharmacology integrated molecular docking strategy was performed to systematically evaluate its pharmacological mechanisms, were further validated in rats with cerebral ischemia. A total 361 potential SAC-related targets predicted SwissTargetPrediction and...
The relationship between hematocrit (HCT) levels and the occurrence of major adverse cardiovascular events (MACEs) in patients with acute myocardial infarction (AMI) remains unexplored. A better understanding this interplay may enhance prognosis management AMI patients. Between January 2021 August 2022, clinical data were collected from diagnosed at 10 tertiary healthcare institutions China. total 1946 eligible participants included divided into three groups based on sex-specific tertiles...
Ethnopharmacological relevance Community-acquired pneumonia (CAP) is an acute inflammation of the alveoli and distal bronchi caused by bacterial, viral, or other pathogenic microbial infections. Yinhua Pinggan (YHPG) granules have demonstrated anti-inflammatory, antibacterial, antiviral effects, suggesting their potential as a treatment option for CAP. Aim To assess efficacy safety traditional Chinese medicine (TCM), YHPG granules, in combination with conventional treatments. Materials...
Introduction Carbapenem-resistant Klebsiella pneumoniae (CRKp) infection poses a significant global public health challenge, with the misuse of antibiotics further contributing to development resistance and triggering harmful inflammatory responses. Outer membrane vesicles (OMVs) released by CRKp under sub-lethal concentration MEM pressure (KOMV-MEM) exhibit enhanced virulence greater efficiency in transferring genes. Methods We investigated inhibitory effects chlorogenic acid (CA) on...
Astragaloside IV and tetramethylpyrazine have been extensively used in the cardio-cerbrovascular diseases of medicine as a chief ingredient glycoside or alkaloid formulations for treatment stroke myocardial ischemia diseases.To investigate effects astragaloside (ASG IV) (TMPZ) on cerebral ischemia-reperfusion (IR) injury model rat model.Rats were randomly divided into following five groups: sham group, IR group including ASG IV, IV-TMPZ nimodipine treatment. The therapeutic effect was...
Cardiovascular diseases (CVDs) are significant causes of morbidity and mortality worldwide, pathological cardiac hypertrophy (PCH) is an essential predictor many heart diseases. Guanxinshutong capsule (GXST) a Chinese patent medicine widely used in the clinical treatment CVD, In our previous research, we identified 111 compounds GXST. order to reveal potential molecular mechanisms by which GXST treats PCH, this study employed network pharmacology methods screen for active ingredients...
Traditional Chinese Medicine formulas, which are usually considered exerting their holistic clinical benefits via multi-component, multi-target manner, unique resources for the discovery of multi-component drug combinations. In order to screen and optimize functional compound combination (FCC) from TCM, we established a novel four-step 'GCIC' strategy, including 'Global profiling', 'Chemical structural classification', 'Intra-group screening' 'Component-knockout optimization'. Following this...
The protective effect of astragaloside IV (AS-IV) on myocardial injury after infarction has been reported. However, the underlying mechanism is still largely unknown. We established a model in C57BL/6 mice and injected intraperitoneally with 10 mg/kg/d AS-IV for 4 weeks. cardiac function, fibrosis, angiogenesis were investigated by echocardiography, Masson's trichrome staining, CD31 smooth muscle actin respectively. Cardiac mitochondrial morphology was visualized transmission electron...
This study aimed to explore the mechanisms through which salvianolic acid B (Sal-B) exerts its effects during myocardial ischemia-reperfusion injury (MI/RI), aiming demonstrate potential pharmacological characteristics of Sal-B in management coronary heart disease. First, Sal-B-related targets and MI/RI-related genes were compiled from public databases. Subsequent functional enrichment analyses using protein–protein interaction (PPI) network, gene ontology (GO), Kyoto Encyclopedia Genes...
Guhong injection (GHI) is a drug for ischemic stroke created by combining safflower, traditional Chinese medicine, and aceglutamide, Western medicine. In this study, we investigated the curative effect of GHI on cerebral ischemia–reperfusion (I/R) injury via PKC/HIF-1α pathway in rats. Adult male Sprague Dawley rats were randomly divided into seven groups: sham-operated, middle artery occlusion (MCAO), GHI, nimodipine (NMDP), MCAO + LY317615 (PKC inhibitor), LY317615, NMDP LY317615. After...
The aim of this study was to investigate the protective effect chuanxiongzine-puerarin on cerebral ischemia-reperfusion damage in a rat model.Rats were randomized into following three groups: control group (sham operation group), model (cerebral and treatment (puerarin group, nimodipine group). neurological deficit, infarct volume levels superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO), synaptophysin, interleukin-1 assessed. therapeutic also evaluated micro-positive...
Background: In China, the combination of herb Salvia miltiorrhiza Bge. (Danshen) and Carthamus tinctorius L. (Honghua) is an effective treatment for stroke. A previous study showed that four herbal components: danshensu (DSS), hydroxysafflor yellow (HSYA), salvianolic acid (SAA), B (SAB) was cerebral ischemia-reperfusion (I/R) injury in rats. However, pharmacokinetic characteristics this formula require further investigation. The present investigated differences between each component two...