A5015744633- Extracellular vesicles in disease
- Erythrocyte Function and Pathophysiology
- Infant Nutrition and Health
- Protease and Inhibitor Mechanisms
- Phagocytosis and Immune Regulation
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Immune cells in cancer
Slovak Academy of Sciences
2018-2019
Comenius University Bratislava
2018-2019
Institute of Molecular Biology of the Slovak Academy of Sciences
2018
The plasminogen system is essential for dissolution of fibrin clots, and in addition, it involved a wide variety other physiological processes, including proteolytic activation growth factors, cell migration, removal protein aggregates. On the hand, uncontrolled contributes to many pathological processes (e.g. tumor cells' invasion cancer progression). Moreover, some virulent bacterial species Streptococci or Borrelia) bind human hijack host's penetrate tissue barriers. Thus, conversion...
Abstract The plasminogen system is harnessed in a wide variety of physiological processes, such as fibrinolysis, cell migration, or efferocytosis; and accordingly, it essential upon inflammation, tissue remodeling, wound healing, for homeostatic maintenance general. Previously, we identified receptor the mannose 6-phosphate/insulin-like growth factor 2 (M6P/IGF2R, CD222). Here, demonstrate by means genetic knockdown, knockout, rescue approaches combined with functional studies that M6P/IGF2R...
The mannose 6-phosphate/insulin-like growth factor 2 receptor (CD222, M6P/IGF2R) is a multifunctional transmembrane type I receptor, mostly localized intracellularly, less on the surface of all types mammalian cells. It known both to transport lysosomal enzymes through their 6-phosphate moieties and internalize extracellular ligands like insulin-like or plasminogen. CD222 involved in regulation cell proliferation, migration, T activation, apoptosis. Soluble has been found higher...