A5083278105- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Birth, Development, and Health
- Genetic Syndromes and Imprinting
- Marriage and Family Dynamics
- Reproductive Biology and Fertility
- Lipid metabolism and biosynthesis
- Extracellular vesicles in disease
- Reproductive Health and Technologies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Significance Lipid droplets (LDs) are stored in the embryo throughout preimplantation development. Yet, role of LDs remains unknown. Embryonic diapause (ED) is a temporary arrest an when it waits for uterine receptivity signal to implant. We provide evidence that play crucial maintaining ED. Diapausing embryos exhibit increased release exosomes reflecting elevated embryonic signaling mother. During ED, decrease lipid caused by switch from carbohydrate metabolism catabolism. have also shown...
Advanced paternal age is associated with increased risks for reproductive and offspring medical problems. Accumulating evidence suggests age-related changes in the sperm epigenome as one underlying mechanism. Using reduced representation bisulfite sequencing on 73 samples of males attending a fertility center, we identified 1,162 (74%) regions which were significantly (FDR-adjusted) hypomethylated 403 (26%) being hypermethylated age. There no significant correlations BMI, semen quality, or...
Abstract The sperm epigenome is thought to affect the developmental programming of resulting embryo, influencing health and disease in later life. Age‐related methylation changes old fathers may mediate increased risks for reproductive offspring medical problems. impact paternal age on has been extensively studied humans and, a lesser extent, rodents cattle. Here, we performed comparative analysis effects protein‐coding genes human marmoset methylomes. gained growing importance as non‐human...
A growing number of sperm methylome analyses have identified genomic loci that are susceptible to paternal age effects in a variety mammalian species, including human, bovine, and mouse. However, there is little overlap between different data sets. Here, we studied whether or not on the epigenome been conserved evolution compared methylation patterns orthologous regulatory regions (mainly gene promoters) containing both non-conserved CpG sites 94 36 mouse samples, using bisulfite...
Abstract Paternal obesity is known to have a negative impact on the male’s reproductive health as well of his offspring. Although epigenetic mechanisms been implicated in non-genetic transmission acquired traits, effect paternal gene expression preimplantation embryo has not fully studied. To this end, we investigated whether associated with changes eight-cell stage embryos fathered by males high-fat diet. We used single RNA-seq compare profile generated high fat (HFD) versus control (CD)...