A5039263687- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Pericarditis and Cardiac Tamponade
- Viral Infections and Immunology Research
- Congenital Diaphragmatic Hernia Studies
- Cardiovascular Issues in Pregnancy
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Coronary Artery Anomalies
- Space Exploration and Technology
- Childhood Cancer Survivors' Quality of Life
- Cardiovascular Syncope and Autonomic Disorders
- Turtle Biology and Conservation
- Child and Adolescent Health
- Adolescent and Pediatric Healthcare
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- ECG Monitoring and Analysis
- Respiratory viral infections research
- Space Science and Extraterrestrial Life
- Non-Invasive Vital Sign Monitoring
- Pneumonia and Respiratory Infections
- Cardiovascular Conditions and Treatments
- Esophageal and GI Pathology
Children's Hospital of Philadelphia
2021-2024
University of Pennsylvania
2023
Jones Institute
2023
Abstract Introduction: Disparities in CHD outcomes exist across the lifespan. However, less is known about disparities for patients with admitted to neonatal ICU. We sought identify sociodemographic ICU admissions among neonates born cyanotic CHD. Materials & Methods: Annual natality files from US National Center Health Statistics years 2009–2018 were obtained. For each neonate, we identified sex, birthweight, pre-term birth, presence of CHD, and admission at time as well maternal age,...
Black patients with tetralogy of Fallot (TOF) have higher mortality than White patients. Health disparities related to other patient-important outcomes, such as exercise performance, not been studied in this population. We aimed determine if there are racial performance TOF and investigate possible mediators those disparities. conducted a retrospective single center study aged 8-25 years repaired who completed maximal cardiorespiratory tests between 2007 2020. The primary outcome was percent...
Background: After TOF repair (TOFr), pulmonary regurgitation resulting in right ventricular (RV) dilatation and dysfunction is common. We have previously demonstrated that RV function (RVF) improves the first two years after TOFr, however changes decade TOFr are less known. investigated RVF size (termed remodeling) using echocardiography during TOFr. Methods: Retrospective cohort study of patients who underwent were followed at our institution from 3/2012 to 12/2023. Those with least...
Introduction: Pts with single ventricle (SV) after bidirectional Glenn (BDG) are placed on angiotensin converting enzyme inhibitors (ACEI) to reduce afterload, improve ventricular performance and allow for decreased systemic pulmonary collateral flow (APC). No large scale data exists support ACEI use in BDG pts accomplish this. We hypothesized that may not perform as predicted. Goals: To determine if decreases APC improves function. Methods: Single center retrospective study of all who...
Abstract Introduction: Racial and ethnic disparities in resource use among children with CHD remain understudied. We sought to evaluate associations between race, ethnicity, utilisation CHD. Materials methods: Annual data from the National Health Interview Survey were collected for years 2010–2018. Children self-reported Non-Hispanic White Black or Hispanic ethnicity identified. Resource preceding year was identified four measures: primary place of care visited when sick, receiving...
Abstract Background: Patients with unbalanced common atrioventricular canal can be difficult to manage. Surgical planning often depends on pre-operative echocardiographic measurements. We aimed determine the added utility of cardiac MRI in predicting successful biventricular repair canal. Methods: conducted a retrospective cohort study children who underwent prior repair. Associations between and measures surgical outcome were tested using logistic regression, models compared area under...
Introduction: Late gadolinium enhancement (LGE) in pediatric patients with acute myocarditis has been shown to be a risk factor for adverse events. On follow up cardiac magnetic resonance imaging (CMR), some show improvement and/or resolution of LGE but others do not. Factors associated residual have not described. Hypothesis: Measurements on initial CMR would degree CMR. Methods: We conducted retrospective cohort study <21 years who underwent within 14 days presentation and returned...
Introduction: Patients with tetralogy of Fallot (TOF) from disadvantaged racial and ethnic groups are reported to have worse outcomes, including exercise performance. The underlying mechanisms not fully understood. Hypothesis: We hypothesize that the association performance race is mediated by socioeconomic factors. Methods: conducted a single center retrospective cohort study TOF patients aged 8 - 30 years who underwent maximal stress testing (EST) 2007 2020. primary outcome was...
Introduction: Reconstructed aortas in patients with single ventricle (SV) can dilate progressively over time, possibly due to abnormal flow patterns. Four-dimensional (4D) cardiac magnetic resonance imaging (CMR) assess advanced hemodynamic parameters. This study utilizes 4D CMR the association between ascending aorta (AAo) dynamics of vorticity, viscous energy loss (EL) and kinetic (KE) arch anatomy SV patients. Methods: was a retrospective center all who underwent from June 2021-present....
Introduction: Cardiac magnetic resonance (CMR) provides rich data on myocardial function, including indices such as strain, well tissue characterization. There is no published these values within 2 weeks of the diagnosis myocarditis. We sought to describe findings in children with acute myocarditis who underwent CMR early after presentation and determine relationships between values. Methods: retrospectively reviewed clinical imaging patients <21 years clinically diagnosed 14 days...
Introduction: Patients with single ventricle (SV) anatomy are susceptible to myocardial fibrosis as measured by cardiac magnetic resonance (CMR) imaging. This study investigated the association of diffuse prior Fontan ventricular function and clinical outcomes after completion. Methods: Retrospective cohort consecutive SV patients who underwent CMR T1 mapping Fontan. Native time extracellular volume (ECV) dominant a free wall region interest (ROI) were on pre-Fontan. Longitudinal strain was...
Introduction: Patients who have undergone tetralogy of Fallot (TOF) repair are subject to chronic volume and/or pressure overload, leading a 40% probability right ventricular (RV) failure by the third decade life. We sought identify plasma proteome profile systemic response heart stress better understand mechanisms RV and novel remodeling biomarkers. Methods: with repaired TOF were recruited at time standard care cardiac MRI (CMR) (N=14), blood samples collected. Plasma proteomics was...
Introduction: Circulating biomarkers thought to represent myocardial fibrosis and stretch are understudied in repaired tetralogy of Fallot (TOF) patients. We aim identify associations between right ventricular (RV) left (LV) function measured as strain by cardiac magnetic resonance (CMR) TOF Methods: N-terminal-pro hormone BNP (NTproBNP), galectin-3 (Gal-3) matrix metalloproteinase 1 (MMP1) were serum obtained from patients at the time standard care CMR. High low biomarker groups created...
Introduction: Patients with malaligned common atrioventricular (AV) canal (CAVC) are difficult to manage when one ventricle is borderline hypoplastic. The decision between the single pathway or attempting a biventricular repair depends upon pre-operative parameters which have previously been studied only by echocardiography. purpose of this study was determine utility cardiac magnetic resonance (CMR) in predicting success CAVC. Methods: We performed center, retrospective cohort children...