The REF family of evolutionarily conserved heterogeneous ribonucleoprotein (hnRNP)-like proteins consists one central RNP-type RNA binding domain flanked by Arg-Gly-rich regions variable length. Members this protein bind directly to and the mRNA export factor TAP/Mex67p, it has been suggested that they facilitate recruitment TAP/Mex67p cellular mRNPs. We show are necessary for REFs TAP. Antibodies specific prevent their interaction with in vitro. After microinjection into Xenopus oocytes,...

Obesity is frequently associated with impairments in the social domain, and stress at puberty can lead to long-lasting changes visceral fat deposition behaviors. However, whether stress-induced adipose tissue affect fat-to-brain signaling, thereby orchestrating behavioral changes, remains unknown. We found that peripubertally stressed male—but not female—mice exhibit concomitant increased adiposity sociability deficits. show reduced levels of adipokine nicotinamide phosphoribosyltransferase...

Emerging evidence suggests that hierarchical status provides vulnerability to develop stress-induced depression. Energy metabolic changes in the nucleus accumbens (NAc) were recently related and depression-like behavior. Acetyl-L-carnitine (LAC), a mitochondria-boosting supplement, has shown promising antidepressant-like effects opening therapeutic opportunities for restoring energy balance depressed patients. We investigated impact NAc of antidepressant LAC treatment chronically-stressed...

Debilitating, yet underinvestigated nonmotor symptoms related to mood/emotion, such as depression, are common in Parkinson's disease. Here, we explore the role of depression and amygdala, a brain region robustly linked synucleinopathy. We hypothesized that mood/emotional deficits might accelerate disease-linked symptomatology, including formation α-synuclein pathology. combined elevated corticosterone treatment, modeling chronic stress with model seeded pathology mouse striatum assessed...

Trait anxiety is an important phenotype in the prediction of stress-induced neuropsychiatric disorders. While role trait mental effort and cognitive impairment well documented, much less known about its influence on motivated behaviors physical effort. Here, we investigated anxiety-related differences behavioral neural responses effort-related monetary incentive delay task. Participants prompted with different levels could exert handgrip to earn rewards while a 256-channel...

Abstract Individuals differ in their physiological responsiveness to stressful challenges, and stress potentiates the development of many diseases. Heart rate variability (HRV), a measure cardiac vagal break, is emerging as strong index vulnerability. Thus, it important develop tools that identify predictive markers individual differences HRV without exposing subjects high stress. Here, using machine learning approaches, we show power high-dimensional locomotor responses during novelty...

We discuss an extension of a map between BPS states and free fermions. The involves associated with full two matrix problem which are constructed using sequence integral equations. A parameter set model eigenstates is then related to in SUGRA. Their wave functions characterized by nontrivial dependence on the radial coordinate AdS Sphere, respectively. kernel defining one these constructed.

Emerging evidence is implicating mitochondrial function and metabolism in the nucleus accumbens motivated performance. However, brain vulnerable to excessive oxidative insults resulting from neurometabolic processes, whether antioxidant levels contribute performance not known. Here, we identify a critical role for glutathione (GSH), most important endogenous brain, motivation. Using proton magnetic resonance spectroscopy at ultra-high field both male humans rodent populations, establish that...

Employing the world line spinning particle picture. We discuss appearance of several different 'gauges' which we use to gain a deeper explanation Collective/Gravity identification. transformations and algebraic equivalences between them. For bulk identification develop 'gauge independent' representation where all gauge constraints are eliminated. This reduction' Higher Spin Gravity demonstrates that physical content 4D AdS HS theory is represented by dynamics an unconstrained scalar field in...

Introduction Findings of recent studies indicate that it is possible to enhance cognitive capacities healthy individuals by means individual upper alpha neurofeedback training (NFT). Although these results are promising, most this research was conducted based on high-priced EEG systems developed for clinical and purposes. This study addresses the question whether such effects can also be shown with an easy use comparably low-priced Emotiv Epoc headset available average consumer. In addition,...

Interpersonal skills require mastering a wide range of competencies such as communication and adaptation to different situations. Effective training includes the use videos in which role models perform desired behaviours that trainees can learn through behavioural mimicry. However, new technologies allow ways designing training. In present study, given virtual reality is emerging valuable setting, we compare two demonstration conditions within by investigating extent doppelgangers boost...

<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Objective:</i> Today, stress monitoring on wearable devices is challenged by the tension between high-detection accuracy and battery lifetime driven multimodal data acquisition processing. Limited research has addressed classification cost sensors, particularly when features are cost-dependent. Thus, we design a Cost-Aware Feature Selection (CAFS) methodology that trades-off prediction-power...

This work proposes a complete structure of an EEG biofeedback platform focused on efficient way for its user to learn how self regulate cortical activity. A longitudinal study voluntary training specific electro activity produces any stable changes in the electroencephalogram is also presented. Correlations these with short term memory are hypothesized. In this human brain was seen as electrochemical machine capable receiving stimuli and adapt accordingly. So, only relevant fed back trainee...

The R package micompr implements a procedure for assessing if two or more multivariate samples are drawn from the same distribution.The uses principal component analysis to convert observations into set of linearly uncorrelated statistical measures, which then compared using number methods.This technique is independent distributional properties and automatically selects features that best explain their differences.The appropriate comparing time series, images, spectrometric measures similar...

Social dominance, the main organizing principle of social hierarchies, facilitates priority access to resources by dominant individuals. Throughout taxa, individuals are more likely become if they act first in situations and acting fast may provide evolutionary advantage; yet whether decision-making is a behavioral predisposition persons outside contexts not known. Following characterization participants for dominance motivation, we found that, indeed, men high respond faster-without loss...

Background. Datasets consisting of synthetic neural data generated with quantifiable and controlled parameters are a valuable asset in the process testing validating directed functional connectivity metrics. Considering recent debate neuroimaging community concerning use these metrics for fMRI data, datasets that emulate BOLD signal dynamics have played central role by supporting claims argue favor or against certain choices. Generative models often used studies simulate neuronal activity,...

The paper presents a case report of the therapy by neurofeedback training chronic female schizophrenia outpatient. purpose was to enhance cognition, memory and behavioral performance. We used an intensive approach. All sessions were performed during 4 consecutive days. results showed that patient learnt increase individual alpha amplitude simultaneously decrease beta2 (20-30 Hz) at P4 site active state over sessions. increased 74.73% decreased 13.73%. short term enhanced after training. Her...

Current measures of causality and temporal precedence have limited frequency time resolution therefore may not be viable in the detection short periods specific frequencies. In addition, presence nonstationarities hinders estimation current techniques as they are based on Fourier transforms or autoregressive model estimation. this work we present a combination to measure between stationary nonstationary series, that is sensitive frequency-specific episodes causality. This methodology...

Many studies have demonstrated the relationship between alpha activity and central visual ability, in which ability is usually assessed through static stimuli. Besides circumstance, however real environment there are often dynamic changes peripheral a (i.e., ability) important for all people. So far, no work has reported whether activity. Thus, objective of this study was to investigate their relationship. Sixty-two soccer players performed newly designed vision task stimuli were dynamic,...