A5066847982- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Adipose Tissue and Metabolism
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Receptor Mechanisms and Signaling
- Hormonal Regulation and Hypertension
- Treatment of Major Depression
- Heart Rate Variability and Autonomic Control
- Regulation of Appetite and Obesity
- Circadian rhythm and melatonin
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Chemical synthesis and alkaloids
- Ion channel regulation and function
- Ginkgo biloba and Cashew Applications
- Cholinesterase and Neurodegenerative Diseases
- Muscle Physiology and Disorders
- Biochemical Analysis and Sensing Techniques
- Electrolyte and hormonal disorders
- Neurological Disease Mechanisms and Treatments
- Medicinal Plants and Neuroprotection
- Soil Mechanics and Vehicle Dynamics
- Sphingolipid Metabolism and Signaling
École Polytechnique Fédérale de Lausanne
2018-2023
Yale University
2016-2019
University of Cincinnati
2009-2017
University of Cincinnati Medical Center
2015
BackgroundEmerging evidence points to a central role of mitochondria in psychiatric disorders. However, little is known about the molecular players that regulate neural circuits regulating anxiety and depression how they impact neuronal structure function. Here, we investigated molecules involved mitochondrial dynamics medium spiny neurons (MSNs) from nucleus accumbens (NAc), hub brain's motivation system.MethodsWe assessed individual differences anxiety-like (measured via elevated plus maze...
Dysfunction of medial prefrontal cortex (mPFC) in association with imbalance inhibitory and excitatory neurotransmission has been implicated depression. However, the precise cellular mechanisms underlying this imbalance, particularly for GABAergic transmission mPFC, link rapid acting antidepressant ketamine remains poorly understood. Here we determined influence chronic unpredictable stress (CUS), an ethologically validated model depression, on synaptic markers GABA neurotransmission, a...
Obesity is frequently associated with impairments in the social domain, and stress at puberty can lead to long-lasting changes visceral fat deposition behaviors. However, whether stress-induced adipose tissue affect fat-to-brain signaling, thereby orchestrating behavioral changes, remains unknown. We found that peripubertally stressed male—but not female—mice exhibit concomitant increased adiposity sociability deficits. show reduced levels of adipokine nicotinamide phosphoribosyltransferase...
Glucocorticoids act rapidly at the paraventricular nucleus (PVN) to inhibit stress-excitatory neurons and limit excessive glucocorticoid secretion. The signaling mechanism underlying rapid feedback inhibition remains be determined. present study was designed test hypothesis that canonical receptors (GRs) is required for appropriate hypothalamic-pituitary-adrenal (HPA) axis regulation. Local PVN GR knockdown (KD) achieved by breeding homozygous floxed mice with Sim1-cre recombinase transgenic...
Abstract Mitochondrial dysfunction was highlighted as a crucial vulnerability factor for the development of depression. However, systemic studies assessing stress-induced changes in mitochondria-associated genes brain regions relevant to depression symptomatology remain scarce. Here, we performed genome-wide transcriptomic study examine mitochondrial gene expression prefrontal cortex (PFC) and nucleus accumbens (NAc) mice exposed multimodal chronic restraint stress. We identified pathways...
Stress-associated disorders, including depression and anxiety, impact nearly 20% of individuals in the United States. The social, health, economic burden imposed by stress-associated disorders requires depth research efforts to identify suitable treatment strategies. Traditional medications (e.g., selective serotonin reuptake inhibitors, monoamine oxidase inhibitors) have significant limitations, notably a time lag for therapeutic response that is compounded low rates efficacy. Excitement...
Organismal stress initiates a tightly orchestrated set of responses involving complex physiological and neurocognitive systems. Here, we present evidence for glucagon-like peptide 1 (GLP-1)-mediated paraventricular hypothalamic circuit coordinating the global response. The GLP-1 receptor ( Glp1r ) in mice was knocked down neurons expressing single-minded 1, transcription factor abundantly expressed nucleus (PVN) hypothalamus. Mice with 1-mediated knockdown had reduced...
γ-aminobutyric acid (GABA) inhibitory interneurons play a key role in efferent and afferent control of principle neuron activity the prefrontal cortex (PFC), thereby regulating signal integrity cognitive behavioral processes. Recent evidence suggests that specific subtypes PFC mediate stress-induced depressive-like behaviors. Abnormalities GABA interneurons, particularly somatostatin (human, SST; mouse, Sst) subtype, have been reported postmortem brains depressed subjects include sex...
The nucleus accumbens (NAc) is a brain hub regulating motivated behaviors, including social competitiveness. Mitochondrial function in the NAc links anxiety with competitiveness, and mitochondrial fusion protein mitofusin 2 (Mfn2) neurons regulates anxiety-related behaviors. However, it remains unexplored whether accumbal Mfn2 levels also affect behavior actions emotional domain are driven by distinct cell types. Here, we found that subordinate-prone highly anxious rats show decreased...
Twelve alkaloids (I–XII) comprising of four broad structural types, viz., carboxylated and decarboxylated tryptamines, β–carbolines β–phenethylamines, have been isolated from different parts Desmodium gangeticum DC at stages its development. Two alkaloids, (IX, X), were previously unreported in nature. The occurrence candicine (VIII) a leguminous plant is also new observation.
Chronic stress causes hypothalamo–pituitary–adrenal (HPA) axis hyperactivity and cardiovascular dyshomeostasis. Noradrenergic (NA) neurons in the nucleus of solitary tract (NTS) are considered to play a role these changes. In this study, we tested hypothesis that NTS NA A2 required for HPA responses both acute chronic stress. Adult male rats received bilateral microinjection into 6-hydroxydopamine (6-OHDA) lesion [cardiovascular n = 5; 5] or vehicle 6; 4]. Rats were exposed restraint...