A5057955358- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Toxoplasma gondii Research Studies
- Anesthesia and Neurotoxicity Research
- Complement system in diseases
- Neuroscience and Neuropharmacology Research
- Parasitic Infections and Diagnostics
- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Natural Antidiabetic Agents Studies
- Mosquito-borne diseases and control
- Tryptophan and brain disorders
- Cannabis and Cannabinoid Research
- Heme Oxygenase-1 and Carbon Monoxide
- Mitochondrial Function and Pathology
- S100 Proteins and Annexins
- Medicinal Plant Extracts Effects
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Berberine and alkaloids research
- Porphyrin Metabolism and Disorders
- Prenatal Substance Exposure Effects
- Neonatal Health and Biochemistry
- Sulfur Compounds in Biology
- Pneumocystis jirovecii pneumonia detection and treatment
- Parasitic infections in humans and animals
Nagasaki University
2020-2025
Osaka University
2021-2025
Chiba University
2020-2021
Osaka City University
2021
University of Westminster
2021
Saga University
2019
National Institute of Biomedical Innovation, Health and Nutrition
2017-2018
University of Gothenburg
2009-2018
The University of Tokyo
2003-2007
Abstract Anaphylatoxin C3a is a third complement component (C3)-derived peptide, the multiple functions of which range from stimulation inflammation to neuroprotection. In previous study, we have shown that signaling through receptor positively regulates in vivo neurogenesis adult mouse brain. Here, studied direct effects on whole brain-derived neural progenitor cells (NPCs) vitro. Our results demonstrate NPCs bind specific and reversible manner stimulates neuronal differentiation NPCs....
Adult neurogenesis is regulated by a number of cellular players within the neurogenic niche. Astrocytes participate actively in brain development, regulation mature central nervous system (CNS), and plasticity. They are important regulators local environment adult niches through secretion diffusible morphogenic factors, such as Wnts. control niche also membrane-associated however, identity these factors mechanisms involved largely unknown. In this study, we sought to determine underlying our...
Alveolar macrophages (AMs) are essential for maintaining lung homeostasis. However, their roles in respiratory infections have been controversial because the methods of depleting them often suffered from poor cell selectivity. To resolve this problem, we here used VeDTR technology to generate a transgenic mouse line which AMs can be specifically depleted using diphtheria toxin. When various were examined system, found that prevented proliferation Mycobacterium abscessus. This result differed...
ABSTRACT Alveolar echinococcosis, which is due to the massive growth of larval Echinococcus multilocularis , a life-threatening parasitic zoonosis distributed widely across northern hemisphere. Commercially available chemotherapeutic compounds have parasitostatic but not parasitocidal effects. Parasitic organisms use various energy metabolic pathways that differ greatly from those their hosts and therefore could be promising targets for chemotherapy. The aim this study was characterize...
Acetate is one of the main short chain fatty acids produced in colon when fermentable carbohydrates are digested. It has been shown to affect normal metabolism, modulating mitochondrial function, and acid oxidation. Currently, there no clear consensus regarding effects acetate on tumorigenesis cancer metabolism. Here, we investigate metabolic cancer. HT29 HCT116 cell lines were treated with its effect proliferation, reactive oxygen species, density, permeability transition pore, cellular...
Ionizing radiation persistently reduces the pool of neural stem and progenitor cells (NSPCs) in dentate gyrus (DG) hippocampus, which may explain some learning deficits observed patients treated with radiotherapy, particularly pediatric patients. A single dose 8 Gy irradiation (IR) was administered to brains postnatal day 14 (P14) C57BL/6 mice 1.0 × 105 bromodeoxyuridine-labeled, syngeneic NSPCs were injected into hippocampus 1 day, week or 6 weeks after IR. Cell survival phenotype evaluated...
Toxoplasma gondii is a neurotropic protozoan parasite, which linked to neurological manifestations in immunocompromised individuals as well severe neurodevelopmental sequelae congenital toxoplasmosis. While the complement system first line of host defense that plays significant role prevention parasite dissemination, artfully evades complement-mediated clearance via recruiting regulatory proteins their surface. On other hand, details and interaction brain parenchyma remain elusive. In this...
The pool of neural stem and progenitor cells (NSPCs) in the dentate gyrus hippocampus is reduced by ionizing radiation. This explains, at least partly, learning deficits observed patients after radiotherapy, particularly pediatric cases. An 8 Gy single irradiation dose was delivered to whole brains postnatal day 9 (P9) C57BL/6 mice, BrdU-labeled, syngeneic NSPCs (1.0 × 105 cells/injection) were grafted into each on P21. Three months later, behavior tests performed. Irradiation impaired...
Neural stem cells express cannabinoid CB1 and CB2 receptors the enzymes for biosynthesis metabolism of endocannabinoids (eCBs). Here we have studied role neural cell‐derived eCBs as autonomous regulatory factors during differentiation. First, examined effect an indirect eCB precursor linoleic acid (LA), a major dietary omega‐6 fatty acid, on system in stem/progenitor (NSPCs) cultured DMEM/F12 supplemented with N2 (N2/DF) monolayer cells. LA upregulated system‐related genes...
Heme is an iron-containing tetrapyrrole molecule that functions as a prosthetic group for proteins such mitochondrial respiratory enzymes. Several studies have suggested heme has essential in the construction and maintenance of nervous system. In this study, contents three biologically important forms (types a, b, c) expression biosynthetic enzymes were examined differentiating Neuro2a cells. During neuronal differentiation, there increases cellular levels mRNA rate-limiting biosynthesis,...
Caenorhabditis elegans CLK‐1 was identified from long‐lived mutant worms, and is believed to be involved in ubiquinone biosynthesis. The protein belongs the eukaryotic CLK‐1/Coq7p family, which also similar bacterial Coq7 that hydroxylates demethoxyubiquinone, resulting formation of hydroxyubiquinone, a precursor ubiquinone. In Escherichia coli , corresponding reaction catalyzed by UbiF, member distinct class hydroxylase. Although previous studies suggested CLK‐1/Coq7 family hydroxylase...