A5015528325- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Advanced Radiotherapy Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac Imaging and Diagnostics
- Medical Imaging and Pathology Studies
- Radiation Dose and Imaging
- Radiopharmaceutical Chemistry and Applications
- Traumatic Brain Injury Research
- MRI in cancer diagnosis
- Breast Cancer Treatment Studies
- Schizophrenia research and treatment
- Nuclear reactor physics and engineering
- Lung Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Neuroimaging Techniques and Applications
- Nuclear Physics and Applications
- Diabetic Foot Ulcer Assessment and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Radiation Therapy and Dosimetry
- Image and Signal Denoising Methods
- Biliary and Gastrointestinal Fistulas
- Venous Thromboembolism Diagnosis and Management
Icahn School of Medicine at Mount Sinai
2013-2022
Mount Sinai Hospital
2020
Mount Sinai Medical Center
2001-2017
Mount Sinai Hospital
1996-2014
University of Rochester Medical Center
1992-2005
University of Rochester
1990
University of Massachusetts Chan Medical School
1989
Abstract Traumatic brain injury (TBI) is a risk factor for the later development of neurodegenerative diseases that may have various underlying pathologies. Chronic traumatic encephalopathy (CTE) in particular associated with repetitive mild TBI (mTBI) and characterized pathologically by aggregation hyperphosphorylated tau into neurofibrillary tangles (NFTs). CTE be suspected when behavior, cognition, and/or memory deteriorate following mTBI. Exposure to blast overpressure from improvised...
<h3>Background</h3> Magnetic resonance imaging and positron emission tomography were used to study the size metabolic rate of caudate putamen in 18 patients with schizophrenia (n=16) or schizo-affective disorder (n=2) 24 age- sex-matched control subjects. <h3>Methods</h3> The either never medicated (n=7) drug free (n=11) for a median 3 weeks. During uptake fludeoxyglucose F 18, all performed serial verbal learning test. Positron tomographic magnetic scans coregistered, traced on image....
Abstract Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder most commonly associated with repetitive brain injury (TBI) and characterized by the presence of neurofibrillary tangles tau protein, known as tauopathy. Currently, diagnosis CTE can only be definitively established postmortem. However, new positron emission tomography (PET) ligand, [ 18 F]T807/AV1451, may provide antemortem detection aggregates, thus various tauopathies, including CTE. Our goal was to examine...
Yttrium-90 ( 90 Y)-microspheres administered via the hepatic artery has been used for treatment of unresectable primary or metastatic cancer in liver. Prior to Y therapy, however, activity and percent shunting lungs must be determined, most commonly by gamma camera imaging technetium-99m 99m Tc)-macroaggregated albumin (MAA). The purpose current study was identify evaluate an objective measure correlation MAA distributions thus assess reliability evaluation tumor liver radiation doses....
The speed and accuracy of iterative reconstruction routines for single-photon-emission computed tomography (SPECT) are highly dependent on the projection backprojection algorithms used. A projector-backprojector pair which accounts two-dimensional, spatially blurring encountered in SPECT reduces computational load has been developed. These assume that attenuator is a uniform elliptical cylinder invariant axial direction. They further blur can be modeled using sum several separable functions,...
Simultaneous dual‐isotope SPECT imaging provides a clear advantage in situations where two concurrent metabolic, anatomic, or background measurements are desired. It obviates the need for separate sessions, reduces patient motion problems, and exact image registration between images. However, potential limitation of is contribution scattered primary photons from one radionuclide into second radionuclide's photopeak energy window, referred to here as cross‐talk. Cross‐talk both windows can...
The authors evaluated the rotational symmetry and stationarity of three-dimensional (3-D) modulation transfer function (MTF) single-photon-emission computed tomography (SPECT). Point spread functions (PSF) in scattering media were obtained by placing a point source at varying radial distances from center three differently shaped water-filled phantoms. Results indicate that nonisotropic phantom, 3-D MTF is anisotropic. For off-axis locations becomes increasingly anisotropic as moved radially...
We evaluated the repeatability of calculation myocardial blood flow (MBF) at rest and pharmacological stress, calculated coronary reserve (CFR) utilizing 82Rb PET imaging. The aim research was to prove high for global MBF CFR values good regional values. results will have significant impact on cardiac imaging in terms making it more affordable increasing its use. 12 normal volunteers were imaged during with 2220 MBq each. A GE Advance system used acquire dynamic 50-frame studies. a...
Whole-body (WB) PET/CT imaging currently involves single-frame, i.e., static, PET acquisitions over a set of axial bed positions to form standardized uptake value (SUV) images. However, SUV is considered semi-quantitative due its dependence on post-injection scan time and subject physiology. Recently, we introduced class novel WB dynamic protocols capable acquiring data multiple frames at each enable quantitative parametric imaging. In this study, are validating special 18F-FDG framework...
Amyloid positron emission tomography (PET) imaging with florbetapir 18F (18F-AV-45) allows in vivo assessment of cerebral amyloid load and can be used the evaluation progression Alzheimer's disease (AD) other dementias associated b-amyloid. However, cortical deposition occur healthy cases, as well patients AD quantification burden improve 18F-AV-45 PET evaluations. The is mostly performed by cortical-to-cerebellum standardized uptake value ratio (SUVr). aim our study was to compare two...
The application of restoration filters assumes that the two-dimensional modulation transfer function (2DMTF) is unchanging throughout image. It was hypothesized an approximately stationary camera response could be obtained by combing opposing views using either arithmetic or geometric mean before filtering SPECT (single-photon-emission computed tomography) images. Images Tc-99m point sources at various positions in circular and elliptical phantoms were used to investigate this hypothesis....
The aim of our study was to compare 90Y dosimetry obtained from PET/MRI versus PET/CT post-therapy imaging among patients with primary or metastatic hepatic tumors. First, a water-filled Jaszczak phantom containing fillable sphere 90Y-chloride acquired on both the and systems, in order check cross-calibration modalities. Following selective internal radiation therapy (SIRT) microspheres, 32 were imaged system, immediately followed by study. Reconstructed images transferred common platform...
Yttrium-90 (90Y) radioembolization involves the intra-arterial delivery of radioactive microspheres to treat hepatic malignancies. Though this therapy careful pre-treatment planning and imaging, little is known about precise location once they are administered. Recently, there has been growing interest post-radioembolization imaging using positron-emission tomography (PET) for quantitative dosimetry identifying lesions that may benefit from additional salvage therapy. In study, we aim...
Yttrium-90 (90Y) radioembolization involves the intra-arterial delivery of radioactive microspheres for treating liver tumors. Although primarily a β− emitter, 90Y occasionally emits positrons via internal pair production. There is growing interest in positron emission tomography (PET) imaging these following to localize and quantify their distribution. Due low abundance (0.0032%), PET images are highly sensitive parameters iterative reconstruction algorithms used clinical imaging. In this...
Positron emission tomography (PET) imaging of yttrium-90 in the liver post radioembolization has been shown useful for personalized dosimetry calculations and evaluation extrahepatic deposition. The purpose this study was to quantify benefits several MR-based data correction approaches offered by using a combined PET/MR system improve Y-90 PET imaging. In particular, feasibility motion partial volume corrections were investigated controlled phantom study.The ACR filled with an initial...
Positron emission tomography (PET) imaging with fluorine-18 (18F) Fluorodeoxyglucose (FDG) and flow tracer such as Rubidium-82 (82Rb) is an established method for evaluating ischemic but viable myocardium. However, the high cost of PET restricts its wider clinical use. Therefore, less expensive 18F FDG single photon computed (SPECT) has been considered alternative to imaging. The purpose work compare SPECT in myocardial perfusion/viability imaging.A nonuniform RH-2 thorax-heart phantom was...
Abstract The aim of our study was to compare dosimetry methods for yttrium-90 (90Y) positron emission tomography/computed tomography (PET/CT). Twenty-five patients were taken a PET/CT suite following therapy with 90Y microspheres. low mA, nondiagnostic CT images used attenuation correction and localization the acquisition time 15 min, reconstruction matrix size 200 mm × 75 mm, voxel 4.07 3.00 mm. Two software packages, MIM 6.8 Planet Dose, utilized calculate dosimetry. Three voxel-based...