A5011100155- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Language Development and Disorders
- Neurobiology of Language and Bilingualism
- Genetic Neurodegenerative Diseases
- Reading and Literacy Development
- Cognitive Functions and Memory
- Lysosomal Storage Disorders Research
- Child and Animal Learning Development
- Advanced Neuroimaging Techniques and Applications
- Neural and Behavioral Psychology Studies
- Cellular transport and secretion
- Peripheral Neuropathies and Disorders
- Williams Syndrome Research
- Cognitive Abilities and Testing
- Genetics and Neurodevelopmental Disorders
- Pediatric Pain Management Techniques
- Lipid metabolism and biosynthesis
- Cardiac Arrest and Resuscitation
- Parkinson's Disease Mechanisms and Treatments
- Autoimmune Bullous Skin Diseases
- Memory Processes and Influences
- Glycosylation and Glycoproteins Research
- Biomedical Research and Pathophysiology
- Celiac Disease Research and Management
Georgetown University
2012-2024
Mount Sinai Medical Center
2023
Columbia University Irving Medical Center
2021
Icahn School of Medicine at Mount Sinai
2016-2020
Mount Sinai Beth Israel
2015-2018
Allen Institute for Brain Science
2017
Royal Hallamshire Hospital
2013
Working memory (WM), which underlies the temporary storage and manipulation of information, is critical for multiple aspects cognition everyday life. Nevertheless, research examining WM specifically in older adults remains limited, despite global rapid increase human life expectancy. We examined a large sample ( N = 754) healthy (aged 58-89) non-Western population (Chinese speakers) Taiwan, on digit n-back task. tested not only influence age itself load (1-back vs. 2-back) but also effects...
Abstract Traumatic brain injury (TBI) is a risk factor for the later development of neurodegenerative diseases that may have various underlying pathologies. Chronic traumatic encephalopathy (CTE) in particular associated with repetitive mild TBI (mTBI) and characterized pathologically by aggregation hyperphosphorylated tau into neurofibrillary tangles (NFTs). CTE be suspected when behavior, cognition, and/or memory deteriorate following mTBI. Exposure to blast overpressure from improvised...
Abstract Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder most commonly associated with repetitive brain injury (TBI) and characterized by the presence of neurofibrillary tangles tau protein, known as tauopathy. Currently, diagnosis CTE can only be definitively established postmortem. However, new positron emission tomography (PET) ligand, [ 18 F]T807/AV1451, may provide antemortem detection aggregates, thus various tauopathies, including CTE. Our goal was to examine...
Although declarative memory declines with age, sex and education might moderate these weaknesses. We investigated effects of on nonverbal (recognition) in 704 older adults (aged 58-98, 0-17 years education). Items were drawings real made-up objects. Age negatively impacted memory, though this age effect was moderated by object-type: it steeper for males than females, but only Education positively associated also interacted benefited women more men (countering the effects, especially women),...
Antemortem biomarker support for a diagnosis of clinically probable chronic traumatic encephalopathy
Objective: Here we show longitudinal neuropsychological and structural MRI data of a football player who has endured several concussions. We aim to reveal patterns aiding in understanding progression the disease informing diagnostic criteria. Background:Chronic traumatic encephalopathy (CTE) is neurodegenerative disorder resulting from repetitive mild brain trauma. Currently, definite diagnosis CTE established postmortem, studies are needed facilitate detection during life. Methods:Here...
<h3>Objective:</h3> Assessment of glucocerebrosidase pathways to better understand the pathophysiology sphingolipids in Parkinson Disease (PD) associated with a GBA variant (GBAPD), including sex-specific features. <h3>Background:</h3> Sex-specific differences both idiopathic PD and GBAPD have been reported. Determining blood-based measures pathway, which is perturbed might be useful understanding these differences. <h3>Design/Methods:</h3> Tandem mass spectrometry was utilized assess levels...
OBJECTIVE: To determine whether peripheral s-glucocerebrosidase (GCase) enzyme activity and lipid levels are potential markers for GBA1 mutation Parkinson disease (GBA-PD). BACKGROUND: Mutations in GBA1, which encodes lysosomal GCase, lead to increased glycolipids biallelic Gaucher risk of (PD) the heterozygous form. The relationship between GCase activity, clinical outcomes could identify pharmacodynamic GBA-PD elucidate etiology. DESIGN/METHODS: Sera high level lipidomics dried blood...
<h3>Objective:</h3> To expand the clinical, radiologic and pathologic understanding of VPS16 related dystonia. <h3>Background:</h3> Variants in have been associated with isolated dystonia 35 cases from Chinese European cohorts, including report brainstem signal change on MRI. <h3>Design/Methods:</h3> We describe clinical features 10 additional individuals variants, neuroimaging a subset pathology one, perform pooled analysis published cases. <h3>Results:</h3> 80% were men, mean age onset was...
Chronic post-concussive syndromes are a major source of morbidity and mortality can develop into neurodegenerative disorders such as chronic traumatic encephalopathy (CTE). Methods assessment prediction outcome areas research focus, in particular molecular neuroimaging with positron emission tomography (PET) using ligands for neuropathological lesions plaques tangles. CTE is characterized pathologically by the presence neurofibrillary tau deposits. In living persons, advances diagnosis have...
April 24, 2018April 10, 2018Free AccessHyperechogenicity of the substantia nigra in non-mutation-carrying family members LRRK2 PD (P3.082)Mariel Pullman, Roberto Ortega, Amanda Glickman, Andres Deik Acosta Madiedo, Deborah Raymond, Karen Marder, Nir Giladi, Susan Bressman, Johann Hagenah, Norbert Bruggemann, and Rachel Saunders-PullmanAuthors Info & AffiliationsApril 2018 issue90 (15_supplement)https://doi.org/10.1212/WNL.90.15_supplement.P3.082 Letters to Editor
Pullman, Mariel Y. MD; Lewis, Suzanne K. Brannagan, Thomas H. Saunders-Pullman, Rachel MD, MPH, MS Author Information