A5044535456- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Cerebral Palsy and Movement Disorders
- Neurobiology of Language and Bilingualism
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Autism Spectrum Disorder Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Optical Imaging and Spectroscopy Techniques
- Neural dynamics and brain function
- bioluminescence and chemiluminescence research
- Psychosomatic Disorders and Their Treatments
- Multiple Sclerosis Research Studies
- Cardiac Arrest and Resuscitation
- Ophthalmology and Eye Disorders
- Neurogenesis and neuroplasticity mechanisms
- Traumatic Brain Injury Research
- Parkinson's Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Neonatal and fetal brain pathology
Oxford Medical Diagnostics (United Kingdom)
2022-2024
University of Oxford
2017-2021
Oxford Drug Design (United Kingdom)
2020
Fondazione Santa Lucia
2013-2018
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2018
One factor believed to impact brain resilience the pathological damage of Alzheimer's disease (AD) is so-called “cognitive reserve” (CR). A critical issue that still needs be fully understood mechanism by which environmental enrichme
Abstract Traumatic brain injury (TBI) is a risk factor for the later development of neurodegenerative diseases that may have various underlying pathologies. Chronic traumatic encephalopathy (CTE) in particular associated with repetitive mild TBI (mTBI) and characterized pathologically by aggregation hyperphosphorylated tau into neurofibrillary tangles (NFTs). CTE be suspected when behavior, cognition, and/or memory deteriorate following mTBI. Exposure to blast overpressure from improvised...
Background Behavioural disorders and psychological symptoms of Dementia (BPSD) are commonly observed in Alzheimer's disease (AD), strongly contribute to increasing patients' disability. Using voxel-lesion-symptom mapping (VLSM), we investigated the impact white matter lesions (WMLs) on severity BPSD patients with amnestic mild cognitive impairment (a-MCI). Methods Thirty-one a-MCI (with a conversion rate AD 32% at 2 year follow-up) 26 healthy controls underwent magnetic resonance imaging...
This longitudinal study investigates the modifications in structure and function occurring to typical Alzheimer's disease (AD) brains over a 2-year follow-up, from pre-dementia stages of disease, with aim identifying biomarkers prognostic value. Thirty-one patients amnestic mild cogn itive impairment were recruited followed-up clinical, neuropsychological, MRI assessments. Patients retrospectively classified as AD Converters or Non-Converters, data compared between groups. Cross-sectional at...
Myotonic dystrophy type 1 (DM1), the most common muscular observed in adults, is a genetic multisystem disorder affecting several other organs besides skeletal muscle, including brain. Cognitive and personality abnormalities have been reported; however, no studies investigated brain functional networks their relationship with traits/disorders patients DM1.To use resting-state magnetic resonance imaging to assess potential between changes connectivity within default mode network (DMN) DM1.We...
This study investigates whether different patterns of grey matter (GM) loss may account for the neuropsychological profiles observed in patients with amnestic (a-) and non-amnestic (na-) mild cognitive impairment (MCI), predict pati
Myotonic dystrophy type 1 (DM1) is a multisystemic disorder dominated by muscular impairment and brain dysfunctions. Although damage has previously been demonstrated in DM1, its associations with the genetics clinical/neuropsychological features of disease are controversial. This study assessed differential role gray matter (GM) white (WM) determining higher-level dysfunctions DM1. Ten patients genetically confirmed DM1 16 healthy How affects to produce myotonic matched controls entered...
Constructional apraxia (CA) is often, but not always, observed in patients with Alzheimer's disease (AD). CA usually explained by impairment of either basic perceptual and motor abilities, or executive functions. This study aims to evaluate the structural correlates AD. Forty-eight AD 20 healthy age-matched controls underwent a thorough neuropsychological investigation an MRI scan collect high-resolution T1-weighted data. Patients were classified as having (ADca) (ADnonca) based on...
Autism spectrum disorder is a debilitating condition with possible neurodevelopmental origins but unknown neuroanatomical correlates. Whereas investigators have paid much attention to the cerebral cortex, few studies detailed basal ganglia in autism. The caudate nucleus may be involved repetitive movements and limbic changes of We used immunohistochemistry for calretinin neuropeptide Y 24 age- gender-matched patients autism control subjects ranging age from 13 69 years. Patients had 35%...
The adult form of myotonic dystrophy type 1 (DM1) presents with paradoxical inconsistencies between severity brain damage, relative preservation cognition, and failure in everyday life. This study, based on the assessment connectivity mechanisms plasticity, aimed at reconciling these conflicting issues. Resting-state functional MRI graph theoretical methods analysis were used to assess topological features a large cohort patients DM1. Patients, compared controls, revealed reduced...
The aim of this research was to test a novel in-vivo brain MRI analysis method that could be used in clinical cohorts investigate cortical architecture changes patients with Alzheimer's Disease (AD). Three probable AD and healthy volunteers were assess the results method. first group as "Discovery" cohort, second "Test" cohort last "ATN" (Amyloid, Tau, Neurodegeneration) an ADNI 3 comparing amyloid Tau PET. can detect altered quality grey matter patients, providing additional tool AD,...
Background Amnestic mild cognitive impairment (MCI) is a transitional stage between normal aging and Alzheimer's disease (AD). However, the clinical conversion from MCI to AD unpredictable. Hence, identification of noninvasive biomarkers able detect early changes induced by dementia pressing need. Purpose To explore added value histogram analysis applied measures derived diffusion tensor imaging (DTI) for detecting brain tissue differences AD, MCI, healthy subjects (HS). Study Type...
Abstract To investigate whether the observed anisotropic diffusion in cerebral cortex may reflect its columnar cytoarchitecture and myeloarchitecture, as a potential biomarker for disease‐related changes, we compared postmortem magnetic resonance imaging scans of nine multiple sclerosis brains with histology measures from same regions. Histology measurements assessed cortical minicolumnar structure based on cell bodies associated axon bundles dorsolateral prefrontal (Area 9), Heschl's gyrus...
Abstract Background There has been increasing interest in cortical microstructure as a complementary and earlier measure of neurodegeneration than macrostructural atrophy, but few papers have related diffusion imaging to post-mortem neuropathology. This study aimed characterise the associations between main Alzheimer’s disease (AD) neuropathological hallmarks multiple microstructural measures from vivo MRI. Comorbidities co-pathologies were also investigated. Methods Forty-three autopsy...
Abstract Fronto-temporal dementia (FTD) is a common type of presenile dementia, characterized by heterogeneous clinical presentation that includes three main subtypes: behavioural-variant FTD, non-fluent/agrammatic variant primary progressive aphasia and semantic PPA. To better understand the FTD subtypes develop more specific treatments, correct diagnosis essential. This study aimed to test discrimination power novel set cortical Diffusion Tensor Imaging measures (DTI), on subtypes. A total...
Behavioral disorders and psychological symptoms (BPSD) in Alzheimer's disease (AD) are known to correlate with grey matter (GM) atrophy and, as shown recently, also white (WM) damage. WM damage its relationship GM reported AD, reinforcing the interpretation of AD pathology light a disconnection syndrome. It remains uncertain whether this might account for different BPSD observable AD. Here, we tested hypothesis patterns association between corpus callosum (CC) patients exhibiting one...
Abstract Objective To investigate cortical microstructural measures from diffusion MRI as “neurodegeneration” markers that could improve prognostic accuracy in mild cognitive impairment (MCI). Methods The power of Amyloid/Tau/Neurodegeneration (ATN) biomarkers to predict progression MCI AD or non‐AD dementia was investigated. Ninety patients underwent clinical evaluation (follow‐up interval 32 ± 18 months), lumbar puncture, and MRI. Participants were grouped by stage cerebrospinal fluid...
Biallelic genetic mutations in the Park2 and PINK1 genes are frequent causes of autosomal recessive PD. Carriers single heterozygous may manifest subtle signs disease, thus providing a unique model preclinical One emerging hypothesis suggests that non-motor symptom PD, such as cognitive impairment be due to distributed functional disruption various neuronal circuits. Using resting-state MRI (RS-fMRI), we tested abnormal connectivity within between brain networks account for patients' status....
Abstract Background Frontotemporal lobar degeneration (FTLD) is a neuropathological construct with multiple clinical presentations, including the behavioural variant of frontotemporal dementia (bvFTD), primary progressive aphasia—both non-fluent (nfvPPA) and semantic (svPPA)—progressive supranuclear palsy (PSP) corticobasal syndrome (CBS), characterised by deposition abnormal tau protein in brain. A major challenge for treating FTLD early diagnosis accurate discrimination among different...
Abstract Objectives To investigate the global cortical and regional quantitative features of neural architecture in brains patients with posterior atrophy (PCA) typical Alzheimer’s disease (tAD) compared elderly healthy controls (HC). Methods A novel diffusion MRI method, that has been shown to correlate minicolumnar organization changes cerebral cortex, was used as a surrogate neuropathological dementia. cohort 15 PCA patients, 23 tAD 22 (HC) were enrolled diffusivity among groups. For each...
Abstract Background TDP‐43 (TAR DNA‐binding protein 43) is one of the most frequently observed co‐pathologies in Alzheimer's disease (AD). Recognizing diversity pathological features individuals with AD, including presence TDP‐43, may lead to more personalized and effective treatment approaches. We investigate ante‐mortem cortical microstructural changes MRI subsequent autopsy confirmation Alzheimer’s neuropathological (ADNC) without comorbidity. Method Participants ADNC were obtained from...
Abstract Background TDP‐43 (TAR DNA‐binding protein 43) is one of the most frequently observed co‐pathologies in Alzheimer's disease (AD). Recognizing diversity pathological features individuals with AD, including presence TDP‐43, may lead to more personalized and effective treatment approaches. We investigate ante‐mortem cortical microstructural changes MRI subsequent autopsy confirmation Alzheimer’s neuropathological (ADNC) without comorbidity. Method Participants ADNC were obtained from...
Abstract Background XPro1595 is a selective, brain penetrant neutralizer of soluble TNF with potent anti‐neuroinflammatory effects recently assessed for safety and pharmacological activity in 12‐week, phase‐1b open‐label dose finding study patients AD (NCT03943264). An unbiased screen imaging outcomes revealed signals target engagement gray matter (GM) cortices documented the literature as regions most frequently affected by accumulation amyloid‐beta (Aβ) early late phases (Mattsson et al....