A5012090616- Neonatal and fetal brain pathology
- Neuroscience of respiration and sleep
- Attention Deficit Hyperactivity Disorder
- Birth, Development, and Health
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Pregnancy and preeclampsia studies
- Child Nutrition and Feeding Issues
- Folate and B Vitamins Research
- Muscle metabolism and nutrition
- Mitochondrial Function and Pathology
- Bariatric Surgery and Outcomes
- Metabolism and Genetic Disorders
- Adipose Tissue and Metabolism
- Muscle Physiology and Disorders
- Neonatal Respiratory Health Research
- Retinopathy of Prematurity Studies
- Congenital Anomalies and Fetal Surgery
- Infant Nutrition and Health
- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Barrier Structure and Function Studies
Universidade Federal do Rio Grande do Sul
2016-2022
Universidade Estadual do Oeste do Paraná
2015-2017
Environmental enrichment (EE) is considered an efficient neuroprotector against neonatal hypoxia-ischemia (HI). Nevertheless, the mechanisms involved are not yet clear. In this context, aim of study was to investigate effects HI and environmental stimulation in hippocampus rats at 3 different time points (PND 8, 22 60), evaluating some aspects BBB structure function. Seven-day-old Wistar were divided into four groups: a control group maintained standard environment (CTSE), (CTEE), (HISE)...
Objectives: The attention-deficit/hyperactivity disorder (ADHD) compromises the quality of life individuals including adaptation to social environment. ADHD aetiology includes perinatal conditions such as hypoxic-ischaemic events; preclinical studies have demonstrated attentional deficits and impulsive-hyperactive outcomes after neonatal hypoxic and/or ischaemic intervention, but data are missing understand this relationship. Thus, aim study was evaluate executive function (EF) impulsivity,...
ABSTRACT Introduction : A balanced maternal diet is a determining factor in normal fetal development. The objective of this study was to evaluate the effects protein restriction during pregnancy and lactation on muscle fiber neuromuscular junction (NMJ) morphology rat offspring at 21 days age. Methods Wistar rats were divided into control group (CG), mothers fed (17%), restricted (RG), low‐protein (6%). After period lactation, animals euthanized, soleus muscles obtained from pups for...
Background: Methylphenidate (MPH) is a stimulant drug mainly prescribed to treat cognitive impairments in attention-deficit/hyperactivity disorder (ADHD). We demonstrated that neonatal hypoxia-ischemia (HI) induced attentional deficits rats and MPH administration reversed these deficits. However, effects on memory after the HI procedure have not been evaluated yet. Aims: aimed analyze learning performance of young hypoxic-ischemic associate their with brain-derived neurotrophic factor (BDNF)...
Abstract Folic acid (FA) is a B‐complex vitamin important to the development of fetus, being supplemented during pregnancy. Our recent findings showed that gestation supplementation (normal and excess doses) prevented cognitive deficits BDNF imbalance in adult rats were submitted neonatal hypoxia‐ischemia (HI). To better understand this protective effect, present study aimed evaluate whether FA could be related (1) maternal behavior, memory Na + , K ‐ ATPase activity hippocampus dams; (2) on...
Few studies have explored the effects of combined use alcohol and cigarette in humans, despite its prevalence. Here we evaluated effect isolated on behaviors neuronal parameters rats. Male adult rats were divided into (AL, 2 g/kg, by oral gavage), smoke (TB, six cigarettes, inhalation), (ALTB), or control (CT, water gavage environmental air) groups, treated twice a day (09.00 14.00 h). After 4 weeks, tested open field for behavioral analysis euthanized brain volume estimation counting...
Abstract Neonatal hypoxia‐ischemia (HI) can lead to cognitive impairments and motor dysfunction. Acrobatic exercises (AE) were proposing as therapeutic option manage HI deficits, however, the effects after this treatment are still poorly understood. Therefore, we evaluated of AE protocol on memory brain plasticity markers Rice–Vannucci rodent model. Wistar rats 7th postnatal day (PND) submitted model weaning (PND22) trained for 5 weeks with protocol, then subsequently tests. Our results...
Perinatal asphyxia is a peripartum event that can cause permanent sequelae to the newborns, affecting brain development. Recently, it has been demonstrated epigenetics mechanisms play an important role in this injury and folic acid (FA) supplementation during pregnancy affect these modifications as well gene expression. We have identified both positive negative effects of FA treatment rats submitted model neonatal hypoxia-ischemia (HI). Considering already used pregnant women HI occurs...
Protein restriction implies the functional involvement of several systems and organs, including skeletal muscle, because it is a protein reservoir in body.This study sought to analyze morphological morphometric features muscle fibers neuromuscular junctions (NMJs) extensor digitorum longus (EDL) rats at 365 days age, submitted maternal during gestation lactation periods.Wistar were divided into two groups: Control Groupmothers fed normal-protein diet (17 % protein) pregnancy lactation;...
To evaluate the effects of duodenal-jejunal bypass (DJB) on diaphragm muscle obese rats fed a western diet (WD) .Eighteen male Wistar were standard rodent chow (CTL group) or WD ad libitum. After 10 weeks, submitted to sham (WD SHAM) DJB). The structure, ultrastructure, collagen content and morphometry neuromuscular junctions (NMJs) analyzed two months after surgery.WD SHAM displayed an increase in body weight, Lee index retroperitoneal peri-epididymal fat pads compared CTL group. DJB did...