A5069125555- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Child Nutrition and Water Access
- Neonatal Respiratory Health Research
- Viral gastroenteritis research and epidemiology
- Neuroscience of respiration and sleep
- Folate and B Vitamins Research
- Childhood Cancer Survivors' Quality of Life
- Child Nutrition and Feeding Issues
- Cardiac Arrest and Resuscitation
- Pregnancy and preeclampsia studies
- Growth Hormone and Insulin-like Growth Factors
- Traumatic Brain Injury and Neurovascular Disturbances
- Child and Adolescent Health
- Restraint-Related Deaths
- Nutritional Studies and Diet
- Cystic Fibrosis Research Advances
- Respiratory viral infections research
- Gestational Diabetes Research and Management
- Biomedical Research and Pathophysiology
- S100 Proteins and Annexins
- Dermatological and Skeletal Disorders
- Infant Nutrition and Health
- Child Abuse and Related Trauma
- Homicide, Infanticide, and Child Abuse
Inserm
2016-2025
Nantes Université
2024-2025
Sorbonne Paris Cité
2014-2024
Université Paris Cité
2014-2024
Centre de Recherche Épidémiologie et Statistique
2015-2024
Université Sorbonne Paris Nord
2024
Sorbonne Université
2024
Centre Hospitalier Universitaire de Nantes
2020-2024
Centre d'Investigation Clinique de Nantes
2019-2023
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021
Background Growth charts are an essential clinical tool for evaluating a child's health and development. The current French reference curves, published in 1979, have recently been challenged by the 2006 World Health Organization (WHO) growth charts. Objective To evaluate compare of children who were born between 1981 2007, with WHO curves currently used. Design Anthropometric measurements from children, participated 12 studies, analyzed: 82,151 available 27,257 different age groups, birth to...
Both national and WHO growth charts have been found to be poorly calibrated with the physical of children in many countries. We aimed generate new for French context huge datasets measurements routinely collected by office-based health practitioners.We recruited 32 randomly sampled primary care paediatricians ten volunteer general practitioners from across metropolitan territory who used same electronic medical records software, which we extracted all data paediatric patients, anonymisation....
Abstract Aim Height velocity is considered a key auxological tool to monitor growth, but updated height growth charts are lacking. We aimed derive new French by using big‐data approach based on routine measurements. Methods extracted all data of children aged 1 month–18 years from the electronic medical records 42 primary care physicians, between January 1990 and 8 February 2018, throughout metropolitan territory. derived annual biannual until age 15 Lambda‐Mu‐Sigma method. These were...
To develop and internally validate a new severity score to more accurately assess the clinical forms of acute gastroenteritis (AGE) in children from birth age 5 years. We included consulting for AGE emergency department University Hospital Nantes (March 2017-June 2019). developed evaluated predictive (GASTROVIM score) using classification regression trees. compared its diagnostic performance with two existing scores: Vesikari dehydration scale (CDS). A expert posteriori children's medical...
Abusive Head Trauma (AHT) is a leading cause of morbidity and mortality in infants requiring rapid neuroimaging performance prognostic diagnosis. The Pittsburgh Infant Brain Injury Score (PIBIS) clinical prediction rule (CPR) was derived to identify most likely present brain injury, whose diagnosis would benefit from head CT. Our study aimed externally validate the PIBIS CPR pediatric French population. A retrospective conducted emergency department between 2015 2017. We included all...
Weight, height and body mass index (BMI) growth trajectories have been associated with several chronic diseases in later life. Our aim was to describe a method model individual weight curves during infancy show how it can be used study their determinants relationships health outcomes as well predict BMI trajectories. In the EDEN mother-child cohort, we collected 17 measurements of 16 length/height per child between birth 3 years age 1,900 infants from care booklet clinical examinations at 1...
Objective We aimed to study current practices in growth monitoring by European primary care paediatricians and explore their perceived needs this field. Methods developed a cross-sectional, anonymous on-line survey contacted listed national directories the 18 countries with confederation of paediatricians. Paediatricians participated between April September 2011. Results Of 1,198 from 11 (response rate 13%) who participated, 29% used 2006 World Health Organization Multicentre Growth...
Abstract Background The Intergrowth‐21st ( IG ) project proposed prescriptive fetal growth standards for global use based on ultrasound measurements from a multicounty study of low‐risk pregnancies selected using strict criteria. We examined whether the are appropriate monitoring in France and potential differences could be due to criteria “healthy” pregnancies. Method analysed data femur length abdominal circumference at second and/or third recommended examination 14 607 singleton Elfe...
A better understanding of the healthcare pathway children and adolescents with anorexia nervosa (AN) may contribute to earlier detection disease management. Here we measured compared symptomatic time diagnosis (TTD) (time between first symptoms, as reported by parents, diagnosis) auxological TTD deviation in weight growth curve diagnosis).We performed a monocentric retrospective study including all patients age 9 years 16 who were hospitalized Nantes University Hospital for AN 2013 2016. We...
In light of the burden traumatic brain injury (TBI) in children and excessive number unnecessary CT scans still being performed, new strategies are needed to limit their use while minimising risk delayed diagnosis intracranial lesions (ICLs). Identifying at higher poor outcomes would enable them be better monitored. The blood-based biomarkers glial fibrillar acidic protein (GFAP) ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) could help clinicians this decision. overall aim study is...
Growth monitoring of apparently healthy children aims at early detection serious conditions by use both clinical expertise and algorithms that define abnormal growth. The seven existing provide contradictory definitions growth abnormality have a low level validation. An external validation study with head-to-head comparison the combined impact World Health Organization (WHO) vs national charts on algorithm performance. With case-referent approach, we retrospectively applied all to data for...
The monitoring of head circumference (HC) is essential to early detect any conditions affecting its growth in childhood. A positive secular trend and regional specificities HC suggested the need provide updated national reference charts.We extracted all data collected from 42 primary-care physicians across French metropolitan territory who used same electronic medical-records software. We selected measurements up age five years for children were born after 1990 with birth weight > 2500 g....
This study aimed to evaluate the incidence of self-reported taste and smell alterations (TSA) in cancer paediatric patients impact TSA on nutritional status this population. We also developed validated a composite score detect children undergoing chemotherapy.Paediatric who were chemotherapy oncology unit included. assessed from Gustonco questionnaire which was internally validated, eating behaviour using Child Eating Behaviour Questionnaire, major weight loss defined status. All data...
Objective To determine whether the relative measurement of birth weight (BW) and head circumference (HC) in preterm infants is associated with neurological outcomes. Methods The EPIPAGE-2 Study included 3473 born before 32 weeks’ gestation, classified based on their Z-score BW HC Fenton curves as concordant (≤1 SD apart) or discordant (>1 difference). We defined four mutually exclusive categories: smaller (sBW) BW<HC, (sHC) HC<BW, (CM) both >−1SD small (CsM) ≤−1SD. Neurological...
Deep learning, a subset of artificial intelligence, has gained attention in recent years for its ability to achieve human level performance medical image analysis. As deep learning is increasingly being studied analysis, it essential that clinicians are familiar with underlying principles, strengths, and possible pitfalls their evaluation. This article aims clarify techniques applied analysis help frontline understand how read appraise studies about this new rapidly advancing technology....
Summary Background In several systematic reviews, rapid weight gain in early life has been related to increased risk of later obesity. line with this finding, the “early protein hypothesis” suggests that reducing intake is a potential lever for obesity prevention. Objective To determine whether variability content infant formula used France over period 2003‐2012 significantly associated growth children. Methods A pooled sample infants from EDEN (Etude des Déterminants pré et postnatals de la...
Growth monitoring of apparently healthy children aims at early detection serious conditions through the use both clinical expertise and algorithms that define abnormal growth. Optimization growth requires standardization definition growth, selection priority target is a prerequisite such standardization.To obtain consensus about for children's growth.We applied formal method with modified version RAND/UCLA method, based on three phases (preparatory, literature review, rating), participation...
Abstract Objectives To evaluate the impact of implementing a modified Pediatric Emergency Care Applied Research Network (PECARN) rule including S100B protein assay for managing mild traumatic brain injury (mTBI) in children. Methods A before-and-after study was conducted paediatric emergency department French University Hospital from 2013 to 2015. We retrospectively included all consecutive children aged 4 months 15 years who presented mTBI and were at intermediate risk clinically important...
Abstract Aim We assessed the diagnostic accuracy of serum (1 → 3)‐β‐D‐glucan (BDG) for neonatal invasive candidiasis (NIC) using recommended cut‐off usually used in adults detecting and searched an optimal ruling out NIC. Methods conducted a prospective cross‐sectional study at Nantes University medical centre from January 2017 to July 2018. All consecutive newborn infants less than 28 days corrected age, with clinically suspected NIC, who underwent BDG assay, were included. Sensitivity...
Abstract Aim This study compared the definitions of abnormal growth that are taught across Europe to explain previously reported variations in growth‐monitoring practices. Methods We developed two online surveys 2016 obtain European countries and approached national chairs Confederation Primary Care Paediatricians 18 International Federation Medical Students’ Associations 33 countries. Results obtained from 10 paediatricians students, covering 23 surveyed. Abnormal faltering was always...