A5013919695- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Neonatal Respiratory Health Research
- Central Venous Catheters and Hemodialysis
- Sepsis Diagnosis and Treatment
- Thermal Regulation in Medicine
- Airway Management and Intubation Techniques
- Ultrasound in Clinical Applications
- Poisoning and overdose treatments
- Foreign Body Medical Cases
- Restraint-Related Deaths
- Tumors and Oncological Cases
- Intraoperative Neuromonitoring and Anesthetic Effects
- Pharmaceutical studies and practices
- Neonatal and fetal brain pathology
- Spinal Cord Injury Research
- Advances in Oncology and Radiotherapy
- Traumatic Brain Injury Research
- Cardiac Ischemia and Reperfusion
- Pediatric Pain Management Techniques
- Nosocomial Infections in ICU
Agostino Gemelli University Polyclinic
2005-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2023
Società Italiana di Nefrologia
2021
ORCID
2019
Policlinico S.Orsola-Malpighi
2019
University of Padua
2019
Public Health Department
2019
Azienda Ospedaliera di Padova
2019
Università Cattolica del Sacro Cuore
2006-2018
Intensive Care Society
2012
Background: Positive end-expiratory pressure (PEEP) can be effective in improving oxygenation, but it may worsen or induce intracranial hypertension. The authors hypothesized that the effects of PEEP could related to changes respiratory system compliance (Crs). Methods: A prospective study investigated 21 comatose patients with severe head injury subarachnoid hemorrhage receiving (ICP) monitoring who required mechanical ventilation and PEEP. 13 normal Crs were analyzed as group 8 low B....
Positive end expiratory pressure (PEEP) improves oxygenation by optimizing alveolar recruitment and reducing intrapulmonary shunt. Unfortunately, PEEP can interfere with intracranial (ICP) increasing intrathoracic pressure. We hypothesized that the use of different levels could have an effect on cerebral perfusion (CPP), gas exchange, respiratory system mechanics, hemodynamics in pediatric patients undergoing major neurosurgical procedures.Twenty-one consecutive surgical procedure for tumors...
In pediatric patients, the choice of venous access device currently relies upon operator's experience and preference on local availability specific resources technologies. Though, considering limited options for in children if compared to adults, such clinical has a great critical relevance should preferably be based best available evidence. Though some algorithms have been published over last 5 years, none them seems fully satisfactory useful practice. Thus, GAVePed-which is interest group...
In the last 20 years, rate of exposure to marijuana has increased dramatically, even in pediatric population. Effects intoxication are variable, more severe neurological symptoms can be observed following ingestion, thus hospital or intensive care unit admission is often required. Usually cannabinoids intoxicated patients treated with administration benzodiazepines opioids, accepting related risk intubation and mechanical ventilation. Dexmedetomidine a highly selective α2-adrenergic receptor...
Abstract Background Out-of-hospital cardiac arrest (OHCA) is one of the most dramatic events in pediatric age and, despite advanced neurointensive care, survival rate remains low. Currently, no effective treatments can restore neuronal loss or produce significant improvement these patients. Nerve Growth Factor (NGF) a neurotrophin potentially able to counteract many deleterious effects triggered by OHCA. Transcranial Direct Current Stimulation (tDCS) has been reported be neuroprotective...
Abstract Background Prolonged treatment with analgesic and sedative drugs in the pediatric intensive care unit (PICU) may lead to undesirable effects such as dependence tolerance. Moreover, during analgosedation weaning, patients develop clinical signs of withdrawal, known withdrawal syndrome (WS). Some studies indicate that dexmedetomidine, a selective α2-adrenoceptor agonist, be useful prevent WS, but no clear evidence supports these data. The aims present study are evaluate efficacy...
Comprised of multi-disciplinary stakeholders - frontline staff and patient representative. A brainstorming storming process identified various barriers to optimal mobilisation. Quality improvement tools such as Affinity diagram
Introduction The objective of our present study is to evaluate the impact different PEEP levels on cerebral hemodynamic, gas exchanges and respiratory system mechanics in paediatric patients with post-traumatic brain swelling treated decompressive craniectomy (DC). Materials methods A prospective physiologic was carried out 14 presenting severe traumatic DC. Transcranial Doppler ultrasonography performed middle artery bilaterally after After assessment at ZEEP, intracranial pressure (ICP),...
Pupillometry has been used to assess pain intensity and response analgesic drugs in adults. The aim of this study was verify the usefulness effectiveness pupillometer depth sedation pediatric patients undergoing painful procedures optimize management by observing pupillary variations induced opioids.This is a prospective, monocentric conducted room Pediatric Intensive Care Unit Fondazione Policlinico A. Gemelli Rome. A population 22 who underwent enrolled. Eleven children were sedated opioid...
Background: Both intracavitary electrocardiography (IC-ECG) and ultrasound (US) have been proven to be safe accurate for intraprocedural tip location during central venous catheterization, both are known easily applicable feasible in pediatric patients. Though, no prospective clinical study has directly compared the two methods as regards their applicability, feasibility, procedural time. Methods: This prospectively enrolled all children requiring a access device non-emergency situations,...
The use of peripheral blood hematopoietic stem cells for bone marrow reconstitution after myeloablative therapy is well established in children with malignant disorders. However, the collection very low-body weight (≤10 kg) remains a significant challenge because technical and clinical issues. A male newborn affected by atypical teratoid rhabdoid tumor, diagnosed prenatally, received two cycles chemotherapy following surgical resection. After an interdisciplinary discussion, it was decided...
The frequency and distribution of acute intoxications poisoning from non-pharmacological substances in children was evaluated this observational-descriptive study. This done by analyzing all admissions to the Emergency Room our University Rome during theperiod 1st January 2001 31st December 2012. We found 249 patients aged 0-14 years: 147 males 102 females. highest incidence occurred first 4 years life: 44.2% 1-2 year age-group. Cases were mostly related solvents (44.6%), natural products...
INTRODUCTION: The aim of the work was to update "Guidelines for Management Severe Traumatic Brain Injury" published in 2012, reflect new available evidence, and develop Italian national guideline management severe pediatric head injuries reduce variation practice ensure optimal care patients.EVIDENCE ACQUISITION: MEDLINE EMBASE were searched from January 2009 October 2017. Inclusion criteria English language, populations (0-18 years) or mixed (pediatric/adult) with age subgroup analyses....
Background: Placement of central venous access devices is a clinical procedure associated with some risk adverse events and relevant cost. Careful choice the device, appropriate insertion technique, proper management device are well-known strategies commonly adopted to achieve an optimal result. However, environment where takes place may have impact on overall outcome in terms safety cost-effectiveness. Methods: We carried out retrospective analysis pediatric patients scheduled for major...
Objective: To determine whether non-invasive ventilation (NIV) can avoid the need for tracheal intubation and/or reduce duration of invasive (IMV) in previously intubated patients admitted to pediatric intensive care unit (PICU) and developing acute hypoxemic respiratory failure (AHRF) after major traumatic injury. Study Design: A single center observational cohort study. Setting: Pediatric ICU a University Hospital (tertiary referral Trauma Centre) Population: During 48-month study period,...
Signa Vitae is an international peer-reviewed open access journal, which currently indexed in SCIE, scopus, etc. It covers many aspects of adult, pediatric and neonatal intensive care, anesthesia emergency medicine