A5005509912- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Parkinson's Disease Mechanisms and Treatments
- Treatment of Major Depression
- Neural and Behavioral Psychology Studies
- Advanced MRI Techniques and Applications
- Hearing Loss and Rehabilitation
- Medical Imaging Techniques and Applications
- Celiac Disease Research and Management
- Neuroscience and Music Perception
- Microscopic Colitis
- Obsessive-Compulsive Spectrum Disorders
- Epilepsy research and treatment
- Neonatal and fetal brain pathology
- Hearing, Cochlea, Tinnitus, Genetics
- Long-Term Effects of COVID-19
- Neuroscience and Neuropharmacology Research
- Thyroid Cancer Diagnosis and Treatment
- Attention Deficit Hyperactivity Disorder
- Nerve injury and regeneration
- Genetic Neurodegenerative Diseases
- Neurotransmitter Receptor Influence on Behavior
- Intestinal Malrotation and Obstruction Disorders
- Gambling Behavior and Treatments
Università Cattolica del Sacro Cuore
2014-2024
Agostino Gemelli University Polyclinic
2010-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2024
Institute of Nuclear Physics
2018
Bambino Gesù Children's Hospital
2018
Istituto Superiore di Sanità
2018
Catholic University of America
2003-2016
University of the Sacred Heart
2011
Sapienza University of Rome
2001-2004
Although more patients are surviving COVID-19, there emerging data on a substantial proportion of with persisting, and often debilitating, symptoms sequelae for months following acute COVID-19. This scenario is commonly referred to as post-acute SARS-CoV-2 infection (PASC) or long COVID.1Nalbandian A Sehgal K Gupta et al.Post-acute COVID-19 syndrome.Nat Med. 2021; 27: 601-615Crossref PubMed Scopus (2541) Google Scholar Some the most reported fatigue, weakness, breathlessness, chest pain,...
PURPOSE: To determine the diagnostic capability of thallium-201 ( 201 Tl) single-photon emission computed tomography (SPECT) combined with Epstein-Barr virus DNA (EBV-DNA) in CSF for diagnosis AIDS-related primary CNS lymphoma (PCNSL). PATIENTS AND METHODS: All human immunodeficiency (HIV)–infected patients focal brain lesions observed between June 1996 and March 1998 underwent lumbar puncture Tl SPECT. Each sample was tested polymerase chain reaction (PCR) EBV-DNA. RESULTS: Thirty-one were...
We describe 3 children with new-onset neurocognitive problems after coronavirus disease 2019 (COVID-19), that showed, at the brain [18F]-fluorodeoxyglucose positron emission tomography/computed tomography, hypometabolism in left orbito-frontal region. The voxel-wise analysis confirmed a cluster of hypometabolic voxels this region peak −18/46/−4mm (179 voxels, T-Score 8.1). These findings may explain symptoms some develop COVID-19 and require further investigations
Background: Nerve growth factor (NGF) promotes neural recovery after experimental traumatic brain injury (TBI) supporting neuronal growth, differentiation and survival of cells up-regulating the neurogenesis-associated protein Doublecortin (DCX). Only a few studies reported NGF administration in paediatric patients with severe TBI.Methods: A four-year-old boy persistent unresponsive wakefulness syndrome (UWS) was treated intranasal murine 6 months TBI. The patient received four cycles (0.1...
Abstract Background There is increasing evidence that chronic endotheliopathy can play a role in patients with Post‐Covid Condition (PCC, or Long Covid) by affecting peripheral vascularization. This pilot study aimed at assessing lung perfusion children Long‐COVID 99m Tc‐MAA SPECT/CT. Materials and Methods SPECT/CT was performed pathological cardiopulmonary exercise testing (CPET). Intravenous injections were on the supine position immediately before planar scan according to EANM guidelines...
To characterize clinically and molecularly an early-onset, variably progressive neurodegenerative disorder characterized by a cerebellar syndrome with severe ataxia, gaze palsy, dyskinesia, dystonia, cognitive decline affecting 11 individuals from 3 consanguineous families.We used whole-exome sequencing (WES) (families 1 2) combined approach based on homozygosity mapping WES (family 3). We performed in vitro studies to explore the effect of nontruncating SQSTM1 mutation protein function...
DJ ‐1 mutations are associated to early‐onset Parkinson's disease and accounts for about 1–2% of the genetic forms. The protein is involved in many biological processes its role mitochondrial regulation gaining great interest, even if function mitochondria still unclear. We describe a 47‐year‐old woman affected by multisystem disorder characterized progressive, parkinsonism plus distal spinal amyotrophy, cataracts sensory‐neural deafness with novel homozygous c. 461C >A [p. T154K ]...
Hypoxic-ischemic brain injuries in childhood are associated with poor neurological outcome. Recently, experimental and clinical works show that nerve growth factor (NGF) reduces deficits promotes endothelial cells proliferation angiogenesis following hypoxic-ischemic injuries. After stroke, new neurons express a protein, called doublecortin (DCX), which indicates marker for neurogenesis migrating neuroblasts. This study investigates the effects of intraventricular NGF administration two...
Abstract Although the involvement of dopamine in gambling disorder (GD) has long been hypothesized, its precise role remains unclear. The action synapses is regulated by transporter (DAT). We hereinafter present significant differences between a sample 15 treatment‐seeking GD subjects and 17 healthy controls terms striatal DAT availability, we explore association with reward‐based decision making. performed 123 I‐FP‐CIT Single‐photon emission computed tomography (SPECT) correlated binding...
Background: Major depressive disorder (MDD) has different clinical presentations and is associated with neurobiological alterations. Hopelessness, anhedonia, dissociation represent some of the most pervasive psychopathological symptoms that often lead to suicidal thoughts, attempts, actions. To further research on concept depression endophenotypes, this study aimed assess possible relationships between hopelessness other biological correlates (i.e., striatal dopaminergic dysfunction) in...
Directional deep brain stimulation (DBS) leads allow a fine-tuning control of the field, however, this new technology could increase DBS programming time because higher number possible combinations used in directional than standard nondirectional electrodes. Neuroimaging localization techniques and local field potentials (LFPs) recorded from electrodes implanted basal ganglia are among most studied biomarkers for programing.This study aimed to evaluate whether intraoperative LFPs beta power...
Abstract In a primate model of Parkinson's disease (PD), the benefit extradural motor cortex stimulation (EMCS) was associated with high‐frequency (130 Hz), whereas no significant improvement achieved at 10 Hz or intermediate frequencies stimulation. We report case 72‐year‐old female patient affected by severe PD who underwent bilateral EMCS. baseline med‐off condition unable to arise from chair and stand without assistance. Stimulation 3 60 failed provide any symptoms, whereas, when...