A5041175678- Parasite Biology and Host Interactions
- Nematode management and characterization studies
- Genetics, Aging, and Longevity in Model Organisms
- Helminth infection and control
- Evolution and Genetic Dynamics
- Insect symbiosis and bacterial influences
- Mollusks and Parasites Studies
- Aquatic Invertebrate Ecology and Behavior
Wellcome Sanger Institute
2023-2024
Host-parasite interactions exert strong selection pressures on the genomes of both host and parasite. These can lead to negative frequency-dependent selection, a form balancing that is hypothesised explain high levels polymorphism seen in many immune parasite antigen loci. Here, we sequence several individuals Heligmosomoides bakeri, model house mice, polygyrus, closely related wood mice. Although H. bakeri commonly referred as polygyrus literature, their show divergence are consistent with...
Abstract Host-parasite interactions exert strong selection pressures on the genomes of both host and parasite. These can lead to increased fitness rare alleles, resulting in negative frequency-dependent selection, a form balancing that is hypothesised explain high levels polymorphism seen many immune parasite antigen loci. Despite their economic ecological importance, there limited evidence for parasitism-relevant genes parasitic nematodes. Here, we sequenced several individuals...
Molluscs are a highly speciose phylum that exhibits an astonishing array of colours and patterns, yet relatively little progress has been made in identifying the underlying genes determine phenotypic variation. One prominent example is land snail Cepaea nemoralis for which classical genetic studies have shown around nine loci, several physically linked inherited together as 'supergene', control shell colour banding polymorphism. As first step towards involved, we used whole-genome...
ABSTRACT Hox genes are central to metazoan body plan formation, patterning and evolution, playing a critical role in cell fate decisions early embryonic development invertebrates vertebrates. While the archetypical gene cluster consists of members nine ortholog groups (HOX1-HOX9), arrayed close linkage order which they have their anterior-posterior effects, nematode sets do not fit this model. The Caenorhabditis elegans set is clustered contains only six from four ancestral groups. pattern...
Abstract Hox genes are central to metazoan body plan formation, patterning and evolution, playing a critical role in cell fate decisions early embryonic development invertebrates vertebrates. While the archetypical gene cluster consists of members nine ortholog groups (HOX1-HOX9), arrayed close linkage order which they have their anterior-posterior effects, nematode sets do not fit this model. The Caenorhabditis elegans set is clustered contains only six from four ancestral groups. pattern...