A5039468826- Inflammatory Bowel Disease
- Microscopic Colitis
- Gastrointestinal disorders and treatments
- Autoimmune and Inflammatory Disorders Research
- Intestinal Malrotation and Obstruction Disorders
- Gastrointestinal Bleeding Diagnosis and Treatment
- Pharmaceutical studies and practices
- Diverticular Disease and Complications
- Eosinophilic Esophagitis
- Immunodeficiency and Autoimmune Disorders
- Autoimmune and Inflammatory Disorders
- Appendicitis Diagnosis and Management
- Adolescent and Pediatric Healthcare
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Tumor Research and Treatment
- Gallbladder and Bile Duct Disorders
- Liver Diseases and Immunity
- COVID-19 Clinical Research Studies
- Acute Lymphoblastic Leukemia research
- Pancreatitis Pathology and Treatment
- Gastrointestinal motility and disorders
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Celiac Disease Research and Management
- Viral gastroenteritis research and epidemiology
St. Eugenio Hospital
2020-2024
ASL Roma
2022
Sapienza University of Rome
2009-2019
Policlinico Umberto I
2009-2016
University of Debrecen
2016
Alba Graduate Business School, The American College of Greece
2014
Pediatrics and Genetics
2014
Policlinico Tor Vergata
2014
University of Calgary
2013
To assess bone mineral density (BMD) in children with Crohn's disease (CD) and ulcerative colitis (UC) to investigate the role of inflammation steroids on BMD.Lumbar spine areal BMD was measured by DXA, volumetric then estimated (BMAD); inflammatory cytokines (TNF-alpha, IL-6, IL-10, IL-12) were dosed peripheral blood; cumulative daily doses calculated. Therapy infliximab (IFX) considered for CD patients.Fifty-six patients IBD (35 CD, 21 UC) studied. An inverse correlation found between BMAD...
Empirical dose intensification and therapeutic drug monitoring [TDM] of infliximab [IFX] trough levels [ITLs] antibody to [ATI] assays are recognized approaches for managing loss response [LoR] in patients with inflammatory bowel disease [IBD]. The aim the study was compare these two interventions a clinical setting, terms effectiveness cost savings. Consecutive IBD experiencing LoR were clinically managed according TDM algorithm. A historical group empirically treated patients, whom sera...
There is growing evidence that in Crohn's disease the achievement and maintenance of mucosal healing (MH) through anti-TNFα antibodies may change natural history disease. Few studies evaluating such outcome as a therapeutic goal are available paediatrics. The primary aim study was to assess efficacy biologics obtaining MH paediatric cohort. secondary aims were: (1) response based on early or late treatment introduction combination therapy with immunomodulators versus alone; (2) evaluate...
Crohn's disease is a chronic inflammatory characterized by progressive transmural bowel damage leading to complications. Anti-TNFα therapy effective in achieving mucosal healing (MH), but its efficacy on inflammation has been poorly investigated. The aim of this study evaluate, pediatric disease, the anti-tumor necrosis factor α agents inducing (TH) as assessed ultrasonography (US).Children with requiring were prospectively enrolled. Clinical activity, laboratory tests, endoscopic and small...
OBJECTIVES: The use of tumor necrosis factor-alpha (TNF-α) antagonists has changed the therapeutic strategy for Crohn's disease (CD). Adalimumab (ADA), a fully human anti-TNF-α monoclonal antibody, is an effective therapy patients with CD, both naive and those intolerant or refractory to Infliximab (IFX), chimeric agent. However, ADA rarely reported in pediatric CD. We performed open prospective evaluation short- long-term efficacy safety children moderate-to-severe METHODS: A total 23 CD (9...
The purpose of this article is to prospectively determine the accuracy MR enterography in detecting Crohn disease lesions from jejunum anorectal region pediatric patients, comparison with main reference investigations.Fifty consecutive children known underwent oral contrast agent and gadolinium-chelate intravenous injection. Two radiologists detected localized by dividing bowel into nine segments (450 analyzed 50 patients). Ileocolonoscopy, barium studies, intestinal ultrasound, capsule...
The ideal preparation regimen for pediatric colonoscopy remains elusive, and available preparations continue to represent a challenge children. aim of this study was compare the efficacy, safety, tolerability, acceptance 4 methods bowel cleansing before in children.This randomized, investigator-blinded, noninferiority trial enrolled all children aged 2 18 years undergoing elective referral center gastroenterology. Patients were randomly assigned receive polyethylene glycol (PEG) 4000 with...
The aims of this study were to determine the presence endothelial dysfunction by measuring aortic intima-media thickness (aIMT) and carotid (cIMT) evaluate role traditional risk factors for premature atherosclerosis in children with inflammatory bowel disease (IBD).Thirty-four IBD (25 Crohn [CD] 9 ulcerative colitis [UC]; mean age 11.1 years) 27 healthy subjects matched sex enrolled. In all patients, demographic characteristics (age, sex, body mass index, blood pressure, dyslipidemia, active...
The antitumor necrosis factor α (TNFα) antibodies infliximab and adalimumab are effective in inducing maintaining remission pediatric patients with Crohn disease (CD). aim of the study was to evaluate long-term efficacy safety biological therapy CD followed at a referral center.This work is retrospective observational enrolling treated or beyond induction protocol. patients' data were collected from unit's IBD database (maximum follow-up evaluation after 36 months treatment). evaluated by...