A5058744305- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Renal Transplantation Outcomes and Treatments
- Galectins and Cancer Biology
- Sleep and Wakefulness Research
- Phagocytosis and Immune Regulation
- Helicobacter pylori-related gastroenterology studies
- Immune Response and Inflammation
- Axon Guidance and Neuronal Signaling
- Immunotherapy and Immune Responses
- Sleep and related disorders
- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- Virus-based gene therapy research
- Immunodeficiency and Autoimmune Disorders
- Inflammatory Bowel Disease
- Whipple's Disease and Interleukins
- Cytokine Signaling Pathways and Interactions
Université de Toulouse
2012-2023
Inserm
2008-2023
Centre National de la Recherche Scientifique
2012-2023
Université Toulouse III - Paul Sabatier
2012-2023
Centre de Physiopathologie de Toulouse-Purpan
2012-2015
Institut National de Recherche en Santé Publique
2013
Hôpital Purpan
2011
The epidermis, the outer layer of skin, forms a physical and antimicrobial shield to protect body from environmental threats. Skin injury severely compromises epidermal barrier requires immediate repair. Dendritic T cells (DETC) reside in murine epidermis where they sense skin serve as regulators orchestrators immune responses. Here, we determined that TCR stimulation induces IL-17A production by subset DETC. This IL-17A-producing DETC was distinct IFN-γ producers, despite similar surface...
Spontaneous or chemically induced germline mutations, which lead to Mendelian phenotypes, are powerful tools discover new genes and their functions. Here, we report an autosomal recessive mutation that occurred spontaneously in a Brown-Norway (BN) rat colony was identified as causing marked T cell lymphopenia. This stabilized strain, named BN(m) for "BN mutated." In rats, found the lymphopenia originated thymus, intrinsic CD4 lymphocytes, associated with development of inflammatory bowel...
Although transplantation is the common treatment for end-stage renal failure, allograft rejection and marked morbidity from use of immunosuppressive drugs remain important limitations. A major challenge in field to identify easy, reliable noninvasive biomarkers allowing prediction deleterious alloreactive immune responses tailoring therapy individuals according risk. In this study, we first established that expression RC isoform CD45 molecule (CD45RC) on CD4 CD8 T cells healthy identifies...
The development of inflammatory diseases depends on complex interactions between several genes and various environmental factors. Discovering new genetic risk factors understanding the mechanisms whereby they influence disease is paramount importance. We previously reported that deficiency in Themis1, a actor TCR signaling, impairs regulatory T cell (Treg) function predisposes Brown-Norway (BN) rats to spontaneous bowel (IBD). In this study, we reveal epistasis Themis1 Vav1 controls...
Background Narcolepsy Type I (NT1) is a rare, life-long sleep disorder arising as consequence of the extensive destruction orexin-producing hypothalamic neurons. The mechanisms involved in orexin neurons are not yet elucidated but association narcolepsy with environmental triggers and genetic susceptibility (strong HLA, TCRs other immunologically-relevant loci) implicates an immuno-pathological process. Several studies animal models on human samples have suggested that T-cells main...
Abstract Natural Foxp3+ regulatory T cells (Treg) are of paramount importance for establishing self-tolerance, controlling inflammatory responses and maintaining immune homeostasis. The identification new molecules Treg functions is nowadays an important challenge. We previously reported the implication Themis, a actor TCR signaling, in suppressive capacities. Indeed, from Themis deficient BN rats were defective, leading to development bowel disease. In present study, we show that deficiency...
Abstract Inflammatory bowel diseases (IBD) are chronic inflammatory disorders affecting genetically predisposed hosts. The current challenge lies on the identification of causal gene variants and their contribution to disease physiopathology. We identified a spontaneous mutation in Brown-Norway rats localized 1.2 cM locus containing only 6 genes. showed that bearing present CD4 T cell lymphopenia originates thymus is autonomous. Interestingly, mutated spontaneously develop lesions share many...
Transplantation: July 27, 2008 - Volume 86 Issue 2S p 161 doi: 10.1097/01.tp.0000332271.26358.c5