A5057850428- Sepsis Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- RNA modifications and cancer
- Neonatal and Maternal Infections
- Spine and Intervertebral Disc Pathology
- Osteoarthritis Treatment and Mechanisms
- Circular RNAs in diseases
- Venous Thromboembolism Diagnosis and Management
- Trauma and Emergency Care Studies
- MicroRNA in disease regulation
- Neonatal and fetal brain pathology
- Nail Diseases and Treatments
- Fungal Infections and Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Axon Guidance and Neuronal Signaling
- Neonatal Respiratory Health Research
- Spinal Hematomas and Complications
- Knee injuries and reconstruction techniques
- Hedgehog Signaling Pathway Studies
- Healthcare Systems and Public Health
- Infectious Diseases and Tuberculosis
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Inflammation biomarkers and pathways
- Ferroptosis and cancer prognosis
Guiyang Medical University
2019-2025
Affiliated Hospital of Guizhou Medical University
2019-2025
Brown University
2023-2024
Rhode Island Hospital
2023-2024
Guizhou Provincial People's Hospital
2022
Army Medical University
2021
Army Medical College
2021
Wuhan Union Hospital
2021
Background: The risk of poor surgical site healing in patients with spinal tuberculosis due to M. infection is known be higher than other patients. Early identification and diagnosis are critical if we reduce the disability mortality associated tuberculosis. We aimed develop validate a novel predictive score for predicting following procedure Patients Methods: retrospectively analyzed clinical data who were hospitalized orthopedic ward four regional medical centers Guizhou Province between...
ObjectiveThe mechanisms of chondrocytes ferroptosis in osteoarthritis (OA) have not yet been fully elucidated. This study aimed to identify key related genes (FRGs) involved ferroptosis.MethodsLASSO, SVM-RFE, and receiver operating characteristic curve (ROC) were performed screen differentially expressed FRGs (DEFRGs). Functional analyses conducted using GO, KEGG analyses. Unsupervised clustering analysis was used patterns. The CeRNA network constructed predict the upstream miRNAs lncRNAs....
Aim: Effect of artesunate (ART)-treated bone marrow-derived mesenchymal stem cells-derived exosomes (BMSC-Exos) on osteogenesis and its underlying mechanisms were investigated. Materials & methods: Proliferation, alkaline phosphatase activity calcified nodule formation osteoblasts determined. A mouse model osteoporosis was established by ovariectomy. Results: SNHG7 upregulated in BMSC-Exos twofold, which further enhanced ART-BMSC-Exos about twofold. ART intensified BMSC-Exos-induced...
Background: The role of N6-methyladenosine (m6A)-related long non-coding RNAs (lncRNAs) in osteosarcoma (OS) has not been fully studied yet. We aimed to identify m6A-related lncRNAs that could act as prognostic biomarkers for OS. Methods: Pearson correlation was performed lncRNAs. Univariate and multivariate Cox regression analyses were construct the risk model assess whether score an independent factor patients with Gene Set Enrichment Analysis (GSEA) analyze functions genes high-risk...
Osteoarthritis (OA) is a highly prevalent age-related musculoskeletal disorder that typically results in chronic pain and disability. OA multifactorial disease, with increased oxidative stress, dysregulated inflammatory response, impaired matrix metabolism contributing to its onset progression. The neurohormone melatonin, primarily synthesized by the pineal gland, has emerged as promising therapeutic agent for due potential alleviate inflammation, chondrocyte death minimal adverse effects....
Posttraumatic osteoarthritis (PTOA) arises secondarily to joint trauma and is driven by catabolic inflammatory pathways. Alpha-2-macroglobulin (α
BTLA is a useful biomarker to characterize the immune states of sepsis patients. We investigated association between genetic variations and morbidity MODS in severe traumatic patient. Three tag single nucleotide polymorphisms were genotyped 562 trauma To further elucidate mechanism, mRNA stability, 3ʹ-UTR activity, its expression on T lymphocytes measured. Only rs1982809 which located showed significant clinical relevance with incidence rate MOD scores. The score CC genotype carriers higher...
Abstract Background Osteosarcoma is a primary malignant bone tumor with high metastatic potential and an inferior prognosis. Glycometabolism also plays role in the disease. However, clinical significance of glycometabolism-related genes patients osteosarcoma has been unclear. Methods We downloaded expression profile corresponding data samples from database. Glycometabolism-related gene sets were obtained. Regression analyses performed to construct prognostic signature. The. independent value...
To explore the value of monocyte subsets and CD64 expression in diagnosis prognosis sepsis.A prospective case-control study was designed. 30 septic patients non-septic who were admitted to intensive care unit (ICU) PLA Army Characteristic Medical Center from March 2021 2022 enrolled. After 1, 3, 5 days ICU admission, peripheral blood samples taken patients. Flow cytometry used detect proportion level on surface, difference between two group analyzed. The risk variables for sepsis analyzed...
Abstract Background HLA-DR is a common and significant biomarker in sepsis. However, as of post-traumatic sepsis, there are few studies. This meta-analysis was conducted to evaluate the value diagnosis severe traumatic Methods We developed strategy for literature retrieval from PubMed, MEDLINE, Web Science,EMBASE, Cochrane Library databases. All studies published until June 1, 2021, were retrieved. that included considered adult each study calculated sensitivities specificities. Results The...
Posttraumatic osteoarthritis (PTOA) arises secondary to joint injuries and is characteristically driven by inflammatory mediators. PTOA often studied in the setting of ACL tears. However, a wide range other also lead pathogenesis. The purpose this study was characterize morphological changes uninjured environment. We retrospectively reviewed 14 ACLs from 13 Yucatan minipigs, 7 which had undergone our modified intra-articular drilling (mIAD) procedure, induced through Seven were harvested...
Abstract Background Shock is a common severe complication of trauma and can result in multiple organ dysfunction even death. To improve prognosis, it crucial that clinicians intervene treat occult shock, which shows no obvious changes vital signs. The purpose this study was to develop new, nomogram-based shock prediction score model independent the injury severity score, abbreviated scale, Glasgow coma scale. Our should help diagnose post-traumatic (PTOS) early promptly patient outcomes....
Abstract Background: To investigate the efficacy of percutaneous transforaminal endoscopic discectomy (PTED) in treatment patients who were diagnosed with lumbar disc herniation (LDH) positive nerve root sedimentation sign (NRSS). Methods: A total 86 underwent LDH recruited and divided into NRSS-positive group (n=49) NRSS-negative group(n=37). The visual analog scale (VAS), Japanese Orthopaedic Association (JOA), Oswestry Disability Index (ODI) used to evaluate low back pain functional...
Abstract Background: Trauma patients have an increased risk of deep vein thrombosis (DVT). Early identification with a high DVT after trauma is crucial for thromboembolism prophylaxis. We aimed to develop and prospectively validate novel score based on nomogram predict lower extremity among patients. Methods: Clinical data were collected from 281 who admitted our center within 24 h admission September 2016 January 2019 score. The estimates then calculated the in new study cohort February...