A5100400006- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Antibiotic Resistance in Bacteria
- Neuroscience and Neuropharmacology Research
- Craniofacial Disorders and Treatments
- Plant Disease Resistance and Genetics
- Microbial Natural Products and Biosynthesis
- Cancer therapeutics and mechanisms
- Receptor Mechanisms and Signaling
- Synthesis and Catalytic Reactions
- Bacterial Genetics and Biotechnology
- Cancer-related molecular mechanisms research
- Rice Cultivation and Yield Improvement
- Leaf Properties and Growth Measurement
- Gene expression and cancer classification
- Tracheal and airway disorders
- Cleft Lip and Palate Research
- Cell Image Analysis Techniques
- Wheat and Barley Genetics and Pathology
- Plant Stress Responses and Tolerance
Chinese Academy of Agricultural Sciences
2024
National Engineering Research Center for Information Technology in Agriculture
2022
Hubei Academy of Agricultural Sciences
2021
Huazhong Agricultural University
2012-2020
Guangxi Medical University
2018
Gladstone Institutes
2017
University of California, San Francisco
2017
Lowering total tau levels is an attractive therapeutic strategy for Alzheimer's disease and other tauopathies. High-throughput screening in neurons derived from human induced pluripotent stem cells (iPSCs) a powerful tool to identify tau-targeted therapeutics. However, such screens have been hampered by heterogeneous neuronal production, high cost low yield, multi-step differentiation procedures. We engineered isogenic iPSC line that harbors inducible neurogenin 2 transgene, transcription...
Litter size in sheep is a complex trait controlled by micro-effective polygenes. APAF1, CLSTN2, CTH, PLCB1, PLCB4, and CHST11 are all involved mammalian reproduction. However, the effects of these genes on litter still unclear. Therefore, this study, we used Sequenom MassARRAY® SNP assay technology to type single nucleotide polymorphisms (SNPs) loci six five breeds. The results showed that most breeds contain three genotypes at each locus. Then, conducted population genetic analysis SNPs...
Azinomycin B is a hybrid polyketide/nonribosomal peptide natural product and possesses antitumor activity by interacting covalently with duplex DNA inducing interstrand crosslinks. In the biosynthetic study of azinomycin B, gene (orf1) adjacent to cluster was found be essential for survival producer, Streptomyces sahachiroi ATCC33158. Sequence analyses revealed that Orf1 belongs HTH_42 superfamily conserved bacterial proteins which are widely distributed in pathogenic antibiotic-producing...
Abstract Rice is the most important cereal crop but sensitive to salinity stress. Increased salinization progressively reducing rice productivity, escalating calls for research ensure sustainable food production. The genetic diversity available in cultivars provides a rich resource discovering genes associated with salt tolerance which has not yet been sufficiently utilized. In this study, 54 QTLs were detected through genome‐wide association study (GWAS) using core population consisting of...
The spatial morphological structure of plant leaves is an important index to evaluate crop ideotype. In this study, we characterized the three-dimensional (3D) data ear leaf midrib maize at grain-filling stage using 3D digitization technology and obtained phenotypic values 15 traits covering four different dimensions midrib, which 13 were firstly proposed for featuring structure. Cluster analysis results showed that could be divided into groups, Group I, -II, -III -IV. I contains...
Grain shape strongly influences the economic value and grain yield of rice. Thus, identifying quantitative trait loci (QTLs) for has been a longstanding goal in rice genetic research breeding programs. Single nucleotide polymorphism (SNP) markers are ubiquitous genome more abundant evenly distributed on 12 chromosomes than traditional markers. An F 2 population was genotyped using RICE6K SNP array to elucidate mechanisms governing shape. Thirty-five QTLs were detected 11 over years. The...
Streptomyces sahachiroi ATCC 33158 produces the potent antitumor antibiotic azinomycin B, which is featured with a set of unusual functionalized moieties. However, genetic analyses B biosynthetic pathway are hampered by low efficiency S. manipulation. In this study, we developed two efficient DNA transfer systems for optimizing variety parameters known to affect intergeneric conjugation and protoplast transformation. High efficiencies 4 × 10(2) transformants per μg 2.47 10(-4) conjugants...
How to mine the gene locus for maize carotenoid components is an important research problem in biology study. Along with rapid development of high-throughput biotechnologies, we have produced a large number multi-omics data, including genome, transcriptome, metabolome, phenotype, etc. conjointly analyze these continuous and discrete thus genetic loci that control very biological significance. In this work, use conditional Gaussian Bayesian network learning method construct gene, SNP...