A5100347495- Cardiac Fibrosis and Remodeling
- Renin-Angiotensin System Studies
- MicroRNA in disease regulation
- Receptor Mechanisms and Signaling
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Inflammatory mediators and NSAID effects
- Signaling Pathways in Disease
- Water Treatment and Disinfection
- Psychosomatic Disorders and Their Treatments
- Andrographolide Research and Applications
- Cell Adhesion Molecules Research
- Cancer, Stress, Anesthesia, and Immune Response
- Cytokine Signaling Pathways and Interactions
- TGF-β signaling in diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Electrospun Nanofibers in Biomedical Applications
- Heart Rate Variability and Autonomic Control
- Hormonal Regulation and Hypertension
- Peptidase Inhibition and Analysis
- Coronary Interventions and Diagnostics
- Peroxisome Proliferator-Activated Receptors
- Nitric Oxide and Endothelin Effects
- Pharmaceutical and Antibiotic Environmental Impacts
Nanjing Normal University
2024
Xinjiang Medical University
2016-2024
Fifth Affiliated Hospital of Xinjiang Medical University
2016-2024
Second Affiliated Hospital of Xinjiang Medical University
2024
Affiliated Hospital of Nantong University
2022
Shanghai University
2022
Nantong University
2022
Adverse cardiac remodeling after myocardial infarction (MI) is associated with extremely high mortality rates worldwide. Although optimized medical therapy, Preservation of lusitropic and inotropic function protection against adverse in ventricular structure remain relatively frequent. This study demonstrated that Andrographolide (Andr) significantly ameliorated induced by improves contractile mice LAD ligation compared the control group. Briefly, Andr markedly attenuated fibrosis relieved...
Myocardial remodeling serves an important role in the pathophysiology of coronary heart disease. The angiotensin-converting enzyme (ACE)2-angiotensin-(1-7) [Ang (1‑7)]‑Mas receptor (MasR) axis is a key regulator myocardial and development failure. To investigate how ACE2‑Ang‑(1‑7)‑MasR function on cardiac fibrosis post‑myocardial infarction (MI), male Sprague‑Dawley rats (weight, 200±20 g) were used to establish model by ligating left artery. present study suggests that telmisartan (Tel)...
Human coronary artery endothelial cells (HCAECs) have the potential to undergo fibrogenic endothelial–mesenchymal transition (EndMT), which results in matrix-producing fibroblasts and thereby contributes pathogenesis of cardiac fibrosis. Recently, profibrotic cytokine transforming growth factor-β (TGF-β) is shown be crucial pathogenic driver has been verified induce EndMT. C-Ski an important regulator TGF-β signaling. However, detailed role c-Ski molecular mechanisms by affects TGF-β-induced...
Cardiac fibrosis occurs in ischemic and non-ischemic heart failure, hereditary cardiomyopathy, diabetes aging. Energy metabolism, which serves a crucial function the course treatment of cardiovascular diseases, might have therapeutic benefits for myocardial fibrosis. Ginsenoside Rb3 (G-Rb3) is one main components Ginseng exhibits poor oral bioavailability but still exerts regulate energy metabolism effects some diseases. Therefore, study investigated effect chitosan (CS) @ sodium...
Zileuton has been demonstrated to be an anti-inflammatory agent due its well-known ability inhibit 5-lipoxygenase (5-LOX). However, the effects of zileuton on cardiac remodeling are unclear. In this study, pressure overload-induced were investigated and possible mechanisms examined. Aortic banding was performed mice induce a model, then treated with 1 week after surgery. We also stimulated neonatal rat cardiomyocytes phenylephrine (PE) them zileuton. Our data indicated that protected from...
ABSTRACT Cardiac fibrosis is characterized by over‐deposition of extracellular matrix (ECM) proteins and over‐proliferation cardiac fibroblast, contributes to both systolic diastolic dysfunction in many pathophysiologic conditions. Transforming growth factor β 1 (TGFβ1) as an essential inducing fibrosis. C‐Ski protein has been identified inhibitory regulator TGFβ signaling. In the present study, we revealed repressive effect c‐Ski on TGFβ1‐induced human fibroblast (HCFB) proliferation ECM...
The present study was aimed at investigating the detailed functions of atorvastatin, a lipid-lowering agent, in pathogenesis coronary slow flow (CSF), clinical disease characterized by delayed angiographic opacity without obstructive disease. In study, we successfully identified isolated endothelial progenitor cells (EPCs) from peripheral blood patients with CSF. Their vascular growth factor-A (VEGFA) protein levels were determined using immunoblotting analyses. We cell viability MTT assays,...
Abstract Coronary slow flow (CSF) is characterized by progression of coronary angiography without epicardial stenosis. The aim this study was to explore the potential biomarkers and regulatory mechanism for CSF. Peripheral blood mononuclear cells from 3 cases CSF healthy controls were collected high-throughput sequencing mRNA miRNA, respectively. differentially expressed mRNAs (DE-mRNAs) miRNAs (DE-miRNAs) identified. A total 117 DE-mRNAs 32 DE-miRNAs obtained they mainly enriched in immune...
Myocardial infarction (MI) is the major cause of mortality around world. We recently demonstrated that chick early amniotic fluid (ceAF) can effectively rescue ischemic heart injury, indicating it has a therapeutic function in MI. However, its functional components and underlying mechanisms remain to be clarified. Here, we fraction ceAF, peak 8 (P8), had protective effect on acute P8 significantly decreased cardiomyocyte cross-sectional areas apoptosis MI mice. Using human embryonic stem...
Background: Increasing numbers of patients have recovered from severe coronavirus disease 2019 (COVID-19) in Wuhan, China. This study aimed to evaluate the association psychological distress with resting palpitations those patients. Methods: In this prospective cohort study, consecutive who COVID-19 and complained were included. Dynamic electrocardiogram (ECG) was continuously monitored for 2 hours while at rest. A survey using palpitation frequency scale Hospital Anxiety Depression Scale...