A5063227840- Autophagy in Disease and Therapy
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Hereditary Neurological Disorders
- Photoacoustic and Ultrasonic Imaging
- Medical Image Segmentation Techniques
- Endoplasmic Reticulum Stress and Disease
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Neurotransmitter Receptor Influence on Behavior
Centro de Investigación Biomédica en Red
2020-2023
Biomedical Research Networking Center on Neurodegenerative Diseases
2023
Instituto Cajal
2023
Consejo Superior de Investigaciones Científicas
2023
Instituto de Salud Carlos III
2023
Centre for Biomedical Network Research on Rare Diseases
2020
Institut de Recerca Sant Joan de Déu
2020
Institut d'Investigacions Biomèdiques de Barcelona
2019
Elevation of energy metabolism and disturbance astrocyte number/function in the ventral anterior cingulate cortex (vACC) contributes to pathophysiology major depressive disorder (MDD). Functional hyperactivity vACC may result from reduced astrocytic glutamate uptake increased neuronal excitation. Here we tested this hypothesis by knocking-down transporter GLAST/GLT-1 expression mouse infralimbic (IL, rodent equivalent vACC) or prelimbic (PrL) cortices using RNAi strategies. Unilateral siRNA...
Mutations in the GDAP1 gene cause Charcot-Marie-Tooth (CMT) neuropathy. is an atypical glutathione S-transferase (GST) of outer mitochondrial membrane and contacts with endoplasmic reticulum (MAMs). Here, we investigate role this GST autophagic flux contact sites (MCSs) between mitochondria lysosomes cellular pathophysiology deficiency. We demonstrate that participates basal autophagy its depletion affects LC3 PI3P biology autophagosome biogenesis trafficking from MAMs. also contributes to...
Introduction Alzheimer’s disease remains the most common neurodegenerative disorder, depicted mainly by memory loss and presence in brain of senile plaques neurofibrillary tangles. This is related to several cellular alterations like synapses, neuronal death, disruption lipid homeostasis, mitochondrial fragmentation, or raised oxidative stress. Notably, changes autophagic pathway have turned out be a key factor early development disease. The aim this research determine impact APOE allele ε4...