A5071235010- Infection Control and Ventilation
- Infection Control in Healthcare
- COVID-19 and Mental Health
- Clostridium difficile and Clostridium perfringens research
- Medical Device Sterilization and Disinfection
- COVID-19 and healthcare impacts
- Antifungal resistance and susceptibility
- Indoor Air Quality and Microbial Exposure
- Gut microbiota and health
- COVID-19 epidemiological studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Enterobacteriaceae and Cronobacter Research
- Nosocomial Infections in ICU
- Microscopic Colitis
- Fungal Infections and Studies
- Antibiotic Resistance in Bacteria
- Skin Protection and Aging
- Food Safety and Hygiene
- Antibiotics Pharmacokinetics and Efficacy
- Viral gastroenteritis research and epidemiology
- Dental Research and COVID-19
- Biosensors and Analytical Detection
Louis Stokes Cleveland VA Medical Center
2020-2025
The Ohio State University
2025
Communities In Schools of Orange County
2022-2024
Oregon Medical Research Center
2022-2024
Lindsay Unified School District
2022-2024
University of Pittsburgh
2022-2024
New York Proton Center
2022-2024
Manhattan Institute for Policy Research
2022
Museum of Heilongjiang Province
2021
VA Northeast Ohio Healthcare System
2020
Background-Shortages of personal protective equipment (PPE) including N95 filtering facepiece respirators is an urgent concern in the setting global COVID-19 pandemic. Decontamination PPE could be useful to maintain adequate supplies, but there uncertainty regarding efficacy decontamination technologies.Methods-A modification American Society for Testing and Materials standard quantitative carrier disk test method (ASTM E-2197-11) was used examine effectiveness ultraviolet-C (UV-C) light, a...
In the setting of coronavirus disease 2019 pandemic, efficient methods are needed to decontaminate shared portable devices and large open areas such as waiting rooms. We found that wheelchairs, equipment, room chairs were frequently contaminated with potential pathogens. After minimal manual precleaning visible soiling, application a dilute sodium hypochlorite disinfectant using an electrostatic sprayer provided rapid effective decontamination eliminated benign virus bacteriophage MS2 from...
Contaminated surfaces are a potential source for spread of respiratory viruses including SARS-CoV-2. Ultraviolet-C (UV-C) light is effective against RNA and DNA could be useful decontamination high-touch fomites that shared by multiple users.A modification the American Society Testing Materials standard quantitative carrier disk test method (ASTM E-2197-11) was used to examine effectiveness UV-C rapid plastic airport security bins inoculated at 3 sites with methicillin-resistant...
ABSTRACT Tebipenem pivoxil has potent in vitro activity against Enterobacterales pathogens, but requires combination with β-lactamase inhibitor to achieve carbapenemase producers, including metallo-β-lactamases (MBLs). Herein, we evaluate the potential of tebipenem pivoxil, alone and prodrug experimental MBL CS319 (CS319-piv-SAc), disrupt indigenous mice microbiota colon promote colonization by pathogens. The effect antibiotic treatment (daily for 3 days subcutaneous saline [control],...
A novel 4% hydrogen peroxide disinfectant was effective against methicillin-resistant Staphylococcus aureus (MRSA), Clostridioides difficile spores, carbapenem-resistant Escherichia coli, and 2 strains of Candida auris. In laboratory testing, a sodium hypochlorite caused fading loss pliability hospital mattress, but the did not. These findings suggest that peroxide-based may be useful addition to sporicidal products available for use in healthcare settings.
Abstract We tested the effectiveness of 23 disinfectants used in healthcare facilities against isolates from 4 major clades Candida auris. Sporicidal were consistently effective, whereas quaternary-ammonium had limited activity. Quaternary-ammonium–alcohol and hydrogen-peroxide–based varied C. auris .
Abstract Background: Ultraviolet-C (UV-C) light devices could be useful to reduce environmental contamination with Candida auris . However, variable susceptibility of C. strains UV-C has been reported, and the high cost many limits their use in resource-limited settings. Objective: To evaluate efficacy relatively low-cost (<$15,000 purchase price) against from 4 major phylogenetic clades. Methods: A modification American Society for Testing Materials (ASTM) standard quantitative disk...
Abstract Objective: To investigate the timing and routes of contamination rooms patients newly admitted to hospital. Design: Observational cohort study simulations pathogen transfer. Setting: A Veterans’ Affairs Participants: Patients hospital with no known carriage healthcare-associated pathogens. Methods: Interactions between participants personnel or portable equipment were observed, cultures high-touch surfaces, floors, bedding, patients’ socks skin collected for up 4 days. Cultures...
Abstract Objective: To evaluate the use of colorimetric indicators for monitoring ultraviolet-C (UV-C) light delivery to sites in patient rooms. Methods: In laboratory testing, we examined correlation between changes color 2 commercial and log 10 reductions methicillin-resistant Staphylococcus aureus (MRSA) Clostridioides difficile spores with exposure increasing doses UV-C from a low-pressure mercury room decontamination device. rooms, 1 was used assess dose 27 room. Results: manufacturer’s...
Abstract Objective: To investigate the frequency of environmental contamination in hospital areas outside patient rooms and outpatient healthcare facilities. Design: Culture survey. Setting: This study was conducted across 4 hospitals, clinics, 1 surgery center. Methods: We 3 point-prevalence culture surveys for methicillin-resistant Staphylococcus aureus , vancomycin-resistant enterococci, Clostridioides difficile Candida spp, gram-negative bacilli including Enterobacteriaceae, Pseudomonas...
Abstract A single spray application of a continuously active disinfectant on portable equipment resulted in significant reductions aerobic colony counts over 7 days and recovery Staphylococcus aureus enterococci: 3 93 cultures (3%) versus 11 97 (11%) 20 (21%) quaternary ammonium untreated control groups, respectively.
Abstract Objective: To assess the potential for contamination of personnel, patients, and environment during use contaminated N95 respirators to compare effectiveness interventions reduce contamination. Design: Simulation study patient care interactions using with a higher lower inocula benign virus bacteriophage MS2. Methods: In total, 12 healthcare personnel performed 3 standardized examinations mannequins including (1) control suboptimal respirator handling technique, (2) improved...
Abstract A novel 1-step anionic surfactant disinfectant was effective against Candida auris isolates from the 4 major phylogenetic clades as well methicillin-resistant Staphylococcus aureus (MRSA) and enveloped virus bacteriophage Phi6. This may be a useful addition to products available for use C. .
Vancomycin taper and pulse regimens are commonly used to treat recurrent
Ultraviolet-C (UV-C) light devices are effective in reducing contamination on N95 filtering facepiece respirators. However, limited information is available whether UV-C meet the Food and Drug Administration's (FDA) microbiological requirements for Emergency Use Authorization (EUA) respirator bioburden reduction.We tested ability of 2 boxes to achieve 3-log10 microorganism reductions required EUA reuse by single users. Whole 3M 1860 or Moldex 1513 respirators were inoculated exterior...
Background: Transmission of healthcare-associated pathogens such as Clostridioides difficile and methicillin-resistant Staphylococcus aureus (MRSA) is a persistent problem in healthcare facilities despite current control measures. A better understanding the routes pathogen transmission needed to develop effective Methods : We conducted an observational cohort study acute-care hospital identify timing route transfer rooms newly admitted patients with negative MRSA nares results no known...
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Abstract Background During the Coronavirus Disease 2019 pandemic, shortages of personal protective equipment (PPE) have forced many healthcare facilities to require personnel reuse N95 respirators. We hypothesized that use correct technique such as changing gloves after contact or providing rapid decontamination between each would reduce risk for contamination. Methods conducted a randomized crossover study using simulated patient care interactions compare effectiveness interventions...
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