A5073045360- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Mosquito-borne diseases and control
- COVID-19 epidemiological studies
- COVID-19 Clinical Research Studies
- COVID-19 Pandemic Impacts
- Cerebral Venous Sinus Thrombosis
- COVID-19 and Mental Health
- Vector-Borne Animal Diseases
- Viral Infections and Outbreaks Research
- T-cell and Retrovirus Studies
- PARP inhibition in cancer therapy
- Parasitic Infections and Diagnostics
- Pituitary Gland Disorders and Treatments
- Cancer-related Molecular Pathways
- Parasitic infections in humans and animals
- Hearing, Cochlea, Tinnitus, Genetics
- Parasite Biology and Host Interactions
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Neuroscience of respiration and sleep
- Vestibular and auditory disorders
- Phagocytosis and Immune Regulation
- Fashion and Cultural Textiles
- Cultural and Historical Studies
Swedish Veterinary Agency
2020-2024
Seoul National University Bundang Hospital
2024
Keimyung University
2020-2022
We have previously provided the first genetic evidence that angiotensin converting enzyme 2 (ACE2) is critical receptor for severe acute respiratory syndrome coronavirus (SARS-CoV), and ACE2 protects lung from injury, providing a molecular explanation failure death due to SARS-CoV infections. has now also been identified as key SARS-CoV-2 infections, it proposed inhibiting this interaction might be used in treating patients with COVID-19. However, not known whether human recombinant soluble...
There is a critical need for safe and effective drugs COVID-19. Only remdesivir has received authorization COVID-19 been shown to improve outcomes but not decrease mortality. However, the dose of limited by hepatic kidney toxicity. ACE2 cell surface receptor SARS-CoV-2. Here, we investigated additive effect combination therapy using with recombinant soluble (high/low dose) on Vero E6 organoids, targeting two different modalities SARS-CoV-2 life cycle: entry via its intracellular viral RNA...
Abstract Climate change and population densities accelerated transmission of highly pathogenic viruses to humans, including the Crimean–Congo haemorrhagic fever virus (CCHFV). Here we report that Low Density Lipoprotein Receptor (LDLR) is a critical receptor for CCHFV cell entry, playing vital role in infection culture blood vessel organoids. The interaction between LDLR specific, with other members protein family failing bind or neutralize virus. Biosensor experiments demonstrate...
Crimean-Congo Hemorrhagic Fever (CCHF) is a severe tick-borne viral hemorrhagic disease caused by Virus (CCHFV) that poses serious public health challenges in many parts of Africa, Europe and Asia.We examined 500 cattle sera samples from five districts for CCHFV antibodies using in-house commercially available (IDVet) ELISA, Immunofluorescent assay (IFA) Real-time polymerase chain reaction (RT-PCR).500 (73.8 % females) were analyzed; seropositivity was 12.6 (n = 63) 75.0 375) with the IDVet...
Marburg and Ebola filoviruses are two of the deadliest infectious agents several outbreaks have occurred in last decades. Although receptors co-receptors been reported for virus, key host factors remain to be elucidated. In this study, using a haploid cell screening platform, we identify guanine nucleotide exchange factor CCZ1 as early stage filovirus replication. The critical role infections is validated 3D primary human hepatocyte cultures blood-vessel organoids, both target sites virus...
Bluetongue virus (BTV), an arbovirus of ruminants, is a causative agent numerous epidemics around the world. Due to emergence novel reassortant BTV strains and new outbreaks, there unmet need for efficacious antivirals. In this study, we used improved haploid screening platform identify relevant host factors infection. Our tool identified validated factor Niemann-Pick C1 (NPC1), lysosomal membrane protein that involved in cholesterol transport, as critical This finding prompted us...
While having already killed more than 7 million of people worldwide in 4 years, SARS-CoV-2, the etiological agent COVID-19, is still circulating and evolving. Understanding pathogenesis virus capital importance. It was shown that vitro vivo infection with SARS-CoV-2 can lead to cell cycle arrest but effect on associated mechanisms are unclear. By stopping cells G1 phase as well targeting several pathways involved using inhibitors small interfering RNAs, we were able determine late beneficial...
Intracranial hypotension (IH) is characterized by postural headache, subdural effusion, cranial nerve palsy, and altered mental status. Cerebral venous thrombosis (CVT) a rare complication secondary to IH. Anticoagulation currently the mainstay of treatment CVT. However, mechanical thrombectomy (MT) may be needed for patients who develop progressive neurologic worsening despite adequate anticoagulation. Here, we report case CVT iatrogenic IH that was successfully treated using MT. Key words:...
Most countries in Europe failed to contain COVID-19, resulting many confirmed cases and deaths. This has resulted multiple European nations implementing large-scale lockdowns. Sweden on the other hand emphasized trust civic responsibility maintain social distancing. Due lack of lockdowns, been criticized internationally for relying a herd immunity strategy. despite statements from both Swedish government Public Health Agency stating that never national In this text COVID-19 strategy will be...
Most countries in Europe failed to contain COVID-19, resulting many confirmed cases and deaths. This has resulted multiple European nations implementing large-scale lockdowns. Sweden on the other hand emphasized trust civic responsibility maintain social distancing. Due lack of lockdowns, been criticized internationally for relying a herd immunity strategy. despite statements from both Swedish government Public Health Agency stating that never national In this text COVID-19 strategy will be...
Central positional nystagmus arises due to disruption of brainstem or cerebellar vestibular networks. Most patients with central had lesions focal diffusion pontine lesion. From a clinical perspective, the presence is thus highly predictive in posterior fossa, including apparatus, nuclei, and midline structures within vermis. We experienced infarction dentate nucleus.
미일 동맹을 토대로 인도태평양전략에 주도적 역할을 추구해 오던 일본이 금년들어 국가안보전략 개정 등을 검토하면서, 5년 이내 GDP 대비 2% 이상이라는 ‘근본적 방위력 건설’과 함께 ‘적기지 공격 능력 보유’ 등 안보정책의 획기적 변화 가능성을 보여주고 있다. 일본의 국가안보전략의 변화를 미일동맹과 인도태평양전략과의 상관성 관점에서 분석하고, 현재 일본 외무성과 방위성의 인도태평양 추진전략과 주요 쟁점을 통해 한반도 안보에 주는 함의를 도출한다. 이러한 국가안보전략은 미일동맹 일체화와 글로벌 차원의 군사적 역할이 확대되고 있으며, 최근 러시아의 우크라이나 침공과 중국의 대만침공 군사훈련 사례를 분석한다. 이를 인도태평양전략 관련 제시된 미일쟁점은 러시아와 북한의 ‘핵선제 사용’에 대비한 ‘핵 공유’ 공론화와 추진에 있어 역할분담, 지역 내 유사시 대비를 위한 준비태세 등이다. 양국은 인도-태평양 전략을 안정과 국제질서를 견지하고 상호역할을 분담하고 영역으로 확대해 나가고...