A5047005201- Animal Nutrition and Physiology
- Animal Behavior and Welfare Studies
- Thyroid Disorders and Treatments
- Animal Behavior and Reproduction
- Neuroscience and Neuropharmacology Research
- Growth Hormone and Insulin-like Growth Factors
- Health and Medical Studies
- Regulation of Appetite and Obesity
- Aquatic Ecosystems and Phytoplankton Dynamics
- Meat and Animal Product Quality
- Adipose Tissue and Metabolism
- Genetics and Neurodevelopmental Disorders
- Livestock and Poultry Management
- Olfactory and Sensory Function Studies
- Insect Utilization and Effects
- French Urban and Social Studies
- Health Systems, Economic Evaluations, Quality of Life
- Stress Responses and Cortisol
- Human-Animal Interaction Studies
- Primate Behavior and Ecology
- Fish Ecology and Management Studies
- Neuroendocrine regulation and behavior
- Pharmaceutical Economics and Policy
- Cassava research and cyanide
- Oceanographic and Atmospheric Processes
Institut de Génomique Fonctionnelle de Lyon
2014-2024
École Normale Supérieure de Lyon
2013-2024
Centre National pour la Recherche Scientifique et Technique (CNRST)
2024
Centre National de la Recherche Scientifique
2008-2023
Université Claude Bernard Lyon 1
2013-2023
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2000-2023
Bundesverband Glaukom-Selbsthilfe
2021
Guiana Space Centre
1999-2020
Physiologie de la Reproduction et des Comportements
2000-2013
Université de Tours
2007-2013
Abstract The concept of quality life in animals is closely associated with the concepts animal sentience and welfare. It reflects a positive approach that inquires what like or prefer doing. assessment farm welfare requires good understanding animals' affective experience, including their emotions. However, experience difficult to measure because absence verbal communication. Recent studies field cognitive psychology have shown can be investigated without using communication by examination...
Thyroid hormone is necessary for normal development of the central nervous system, as shown by severe mental retardation syndrome affecting hypothyroid patients with low levels active thyroid hormone. The postnatal defects observed in mouse cerebellum are recapitulated mice heterozygous a dominant-negative mutation Thra, gene encoding ubiquitous TRα1 receptor. Using CRE/loxP-mediated conditional expression approach, we found that this primarily alters differentiation Purkinje cells and...
Mammalian brain development critically depends on proper thyroid hormone signaling, via the TRα1 nuclear receptor. The downstream mechanisms by which impacts are currently unknown. In order to investigate these mechanisms, we used mouse genetics induce expression of a dominant-negative mutation specifically in GABAergic neurons, main inhibitory neurons brain. This triggered post-natal epileptic seizures and profound impairment neuron maturation several regions. Analysis transcriptome...
ABSTRACT One year after impoundment in January 1994, methanotrophic bacteria Petit Saut Reservoir (French Guiana) were active at the oxic-anoxic interface. This activity was revealed by sudden extinction of diffusive methane emission (600 metric tons CH 4 · day −1 for whole lake surface area, i.e., 360 km 2 ). Lifting inhibition suspected. After reviewing potential inhibitors this physiological guild (O , NH + sulfides) and considering similarities with nitrifiers, we suggest that sunlight...
Thyroid hormone (T3) and its nuclear receptors (TR) are important regulators of energy expenditure adaptive thermogenesis, notably through their action in the brown adipose tissue (BAT). However, T3 acts many other peripheral central tissues which also involved expenditure. The general picture how regulates BAT thermogenesis is currently not fully established, due to absence extensive omics analyses lack specific mice model. Here, we first used transcriptome cistrome establish list T3/TR...
Abstract In birds, as in mammals, corticotropin‐releasing factor (CRF) is present a number of extrahypothalamic brain regions, indicating that CRF may play role physiological and behavioral responses other than the control adrenocorticotropin hormone release by pituitary. To provide foundation for investigation roles avian behavior, distribution immunoreactivity was determined throughout central nervous system domestic chicken ( Gallus domesticus ) Japanese quail Coturnix japonica ). The...
Resistance to thyroid hormone due THRA mutations (RTHα) is a recently discovered genetic disease, displaying important variability in its clinical presentation. The alter the function of TRα1, one two nuclear receptors for hormone.The aim this study was understand relationship between specific and phenotype. CRISPR/Cas9 genome editing used generate five new mouse models RTHα, with frameshift or missense mutations.Like human patients, mutant mice displayed hypothyroid-like phenotype, altered...
Abstract Background As for other non-model species, genetic analyses in quail will benefit greatly from a higher marker density, now attainable thanks to the evolution of sequencing and genotyping technologies. Our objective was obtain first genome wide panel Japanese SNP (Single Nucleotide Polymorphism) use it fine mapping QTL fear-related behaviour, namely tonic immobility, previously localized on Coturnix japonica chromosome 1. To this aim, two reduced representations were analysed...
Nanopesticides are innovative pesticides involving engineered nanomaterials in their formulation to increase the efficiency of plant protection products, while mitigating environmental impact. Despite predicted growth nanopesticide use, no data is available on inhalation toxicity and potential cocktail effects between components. In particular, neurodevelopmental caused by prenatal exposures might have long lasting consequences. present study, we repeatedly exposed gestating mice a...
Abstract Thyroid hormone increases energy expenditure. Its action is mediated by TR, nuclear receptors present in peripheral tissues and the central nervous system, particularly hypothalamic neurons. Here, we address importance of thyroid signaling neurons, general for regulation We generated mice devoid functional TR neurons using Cre/LoxP system. In hypothalamus, which center metabolic regulation, mutations were 20% to 42% Phenotyping was performed under physiological conditions that...