A5062937054- Sarcoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Neonatal Health and Biochemistry
- Blood groups and transfusion
- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Vascular Tumors and Angiosarcomas
- Histiocytic Disorders and Treatments
- Tumors and Oncological Cases
- Oral and Maxillofacial Pathology
- Bone Tumor Diagnosis and Treatments
- Parvovirus B19 Infection Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Platelet Disorders and Treatments
- Neurofibromatosis and Schwannoma Cases
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Blood disorders and treatments
- Fibroblast Growth Factor Research
- Vascular Malformations and Hemangiomas
- Cardiac tumors and thrombi
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Surgical Treatments
- Cutaneous lymphoproliferative disorders research
- Melanoma and MAPK Pathways
- Endometrial and Cervical Cancer Treatments
Middlemore Hospital
2020-2024
University of Edinburgh
2024
Cleveland Clinic
2020-2021
Counties Manukau District Health Board
2020-2021
NYU Langone Health
2018-2019
Hutt Hospital
2013-2018
Wellington Hospital
2017
Memorial Sloan Kettering Cancer Center
2017
University of California, Los Angeles
2010-2012
Loyola University Medical Center
2011
Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a highly aggressive malignancy, which was recently found to comprise three major genomic subsets: small carcinoma-like, non-small (predominantly adenocarcinoma)-like, and carcinoid-like. To further characterize adenocarcinoma-like subset, here we analyzed the expression of exocrine marker napsin A, along with TTF-1, in series LCNECs (n=112), performed detailed clinicopathologic analysis A-positive cases. For comparison, A other lung...
Abstract BACKGROUND: Endometrial cancer (EC) is a common malignancy worldwide. It often preceded by endometrial hyperplasia, whose management and risk of neoplastic progression vary. Previously, the authors have shown that tetraspan protein epithelial membrane protein‐2 (EMP2) prognostic indicator for EC aggressiveness survival. Here validate expression EMP2 in EC, further examine whether within preneoplastic lesions an early biomarker development. METHODS: A tissue microarray (TMA) was...
Abstract As the classification of kinase‐driven spindle cell tumors continues to evolve, we describe first series pediatric mesenchymal harboring FGFR1 gene fusions that share histologic overlap with infantile fibrosarcoma and “ NTRK ‐rearranged” neoplasms. Herein, present three cases ‐rearranged tumors, including one case :: PARD6B fusion two EBF2 fusion. The involved infants ranging from 3 9 months in age a male‐to‐female ratio 2:1. All deep soft tissue gluteal, pelvic, or perirectal...
Context.— Bone and soft tissue tumors are heterogeneous, diagnostically challenging, often defined by gene fusions. Objective.— To present our experience using a custom 34-gene targeted sequencing fusion panel. Design.— Total nucleic acid extracted from formalin-fixed, paraffin-embedded (FFPE) tumor specimens was subjected to open-ended, nested anchored multiplex polymerase chain reaction enrichment of 34 targets, thus enabling detection known novel partners. Results.— During 12-month...
Numerous studies have examined the association between ABO blood groups and adult disease states, but very few studied neonatal population. The objective of this study was to determine relationship AB group occurrence common disorders such as neutropenia at birth, sepsis, respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH), retinopathy prematurity (ROP), patent ductus arteriosus (PDA) compared all other groups.We performed a retrospective review on 3,981 infants born 22...
Rosai-Dorfman disease (RDD) is a rare histiocytic proliferative of unknown etiology. Typically presenting with cervical adenopathy and constitutional symptoms, RDD involves bone in less than 10% cases-and rarely presents as primary intraosseous lesion. In this report, we describe the presentation primary, bilateral RDD, first known case literature. Asymmetrically involving lateral femoral condyles 59-year-old male, lesion was discovered incidentally during evaluation workup for giant cell...
Desmoid fibromatosis is a myofibroblastic neoplasm of intermediate biologic potential, which has strong predilection for local recurrence but does not metastasize. Arranged in long, sweeping fascicles with infiltrative borders, desmoid typically consists uniform, bland spindle cells that harbor mutation CTNNB1 (or less often APC) . In this report, we present remarkable case associated striking nuclear pleomorphism. We hypothesize pleomorphism due to germline TP53 mutation, finding first...
Background: The presence of A and B tissue antigens in non-O (A, B, AB) blood types adults is associated with a higher incidence ischemic stroke, myocardial infarction, arterial venous thrombosis. In preterm healthy newborns, plasma concentrations coagulation system proteins like von Willebrand Factor (vWF) are >70% normal adult values levels vWF VIII (FVIII) increases thrombotic risk. Previously we demonstrated an association between neonatal AB type decreased survival necrotizing...
Background: More than half of all very low birth weight (VLBW) newborns will receive at least one transfusion during their stay in the neonatal intensive care unit (NICU). Several recent studies have detected a temporal relationship between anemia requiring red cell and onset necrotizing enterocolitis (NEC). The association anemia, transfusion, NEC is still debated, though associated has reported incidence 5-17 per 1000 events. effect preservatives, additives, decreased ATP, 2,3-DPG...
BACKGROUND Endocan-1, a soluble proteoglycan expressed on endothelial cells, has been reported as marker of pathology in the adult population with sepsis, hypertension, myocardial infarction, and kidney disease. Necrotizing Enterocolitis (NEC) is an acute ischemic necrotizing disease GI tract multifactorial etiology very low birth weight newborns involving large area intestine. Spontaneous Intestinal Perforation (SIP) involves hemorrhagic necrosis small focal lesion earlier onset than NEC....
BACKGROUND Endocan-1, a soluble proteoglycan expressed on endothelial cells, has been reported as marker of pathology in the adult population with sepsis, hypertension, myocardial infarction, and kidney disease. Necrotizing Enterocolitis (NEC) is an acute ischemic necrotizing disease GI tract multifactorial etiology very low birth weight newborns involving large area intestine. Spontaneous Intestinal Perforation (SIP) involves hemorrhagic necrosis small focal lesion earlier onset than NEC....