A5033094717- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Long-Term Effects of COVID-19
- Reproductive System and Pregnancy
- Cytomegalovirus and herpesvirus research
- COVID-19 Impact on Reproduction
- SARS-CoV-2 and COVID-19 Research
- Diet and metabolism studies
- Autoimmune and Inflammatory Disorders Research
- Ocular Infections and Treatments
- Multiple Sclerosis Research Studies
- Viral-associated cancers and disorders
- Retinal and Optic Conditions
- Adipose Tissue and Metabolism
- vaccines and immunoinformatics approaches
- Ocular Surface and Contact Lens
- Peripheral Neuropathies and Disorders
- Herpesvirus Infections and Treatments
- Respiratory viral infections research
- Hepatitis C virus research
- Diet, Metabolism, and Disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Effects and risks of endocrine disrupting chemicals
- Medical and Biological Ozone Research
- Infection Control in Healthcare
University of Ferrara
2021-2025
(1) Background: Acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent for disease (COVID-19) that has led to a pandemic began in March 2020. The role of SARS-CoV-2 components on innate and adaptive immunity still unknown. We investigated possible implication pathogen-associated molecular patterns (PAMPs)-pattern recognition receptors (PRRs) interaction. (2) Methods: infected Calu-3/MRC-5 multicellular spheroids (MTCSs) with clinical strain evaluated activation RNA...
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An efficient host immune response is crucial in controlling viral infections. Despite most studies focused on the implication of T and B cell COVID-19 (Corona Virus Disease-19) patients or their activation after vaccination against SARS-CoV-2, innate has raised even more interest as well. In fact, immunity, including Natural Killer (NK) cells, monocytes/macrophages neutrophils, represent first line defense virus it essential to determine correct an specific acquired response. this...
Recent observations highlight a notable surge in West Nile Virus (WNV) infections Europe that can lead to neuroinvasive consequences associated with neurodegeneration, mainly triggered by WNV Non-Structural protein 1 (NS1). During viral replication, various protein-protein interactions take place, allowing proteins interact host factors. NS1 is actively secreted the bloodstream infected cells and known affect endothelial permeability immune response. Focusing on recently discovered...
Human leukocyte antigen (HLA) is a group of molecules involved in inflammatory and infective responses. We evaluated blood sHLA-E sHLA-G levels hospitalized COVID-19 patients with respiratory failure their relationship clinical evolution, changes endothelial activation biomarker profile, neutrophil adhesion. sHLA-E, sHLA-G, biomarkers were quantified by ELISA assay plasma samples. Neutrophil adhesion to endothelium was assessed the presence/absence patients' At admission, significantly...
Several evidence suggests that, in addition to the respiratory tract, also gastrointestinal tract is a main site of severe acute syndrome CoronaVirus 2 (SARS-CoV-2) infection, as an example multi-organ vascular damage, likely associated with poor prognosis. To assess mechanisms SARS-CoV-2 responsible tissue infection and injury, correlating thrombotic specimens digestive positive for nucleocapsid protein were analyzed deriving from three patients, negative naso-oro-pharyngeal swab...
Coagulation decompensation is one of the complications most frequently encountered in COVID-19 patients with a poor prognosis or long-COVID syndrome, possibly due to persistence SARS-CoV-2 infection cardiovascular system. To date, mechanism underlying alteration coagulation cascade remains misunderstood and anticoagulant protein S (PROS1) has been described as potential risk factor for related COVID-19, PLpro enzyme proteolysis. Biopsies blood samples were collected from positive negative...
: Moxifloxacin is a bactericidal methoxyquinolone used for the treatment of conjunctivitis and prophylactic therapy in cataract refractive surgeries. Chloramphenicol bacteriostatic organochlorine introduced into clinical practice 1948 mainly topical preparations because its known toxicity. The study aimed to evaluate vitro antibacterial effect ocular cytotoxicity these broad-spectrum antibiotics. Antimicrobic activity was tested on four bacterial strains (Escherichia coli, Pseudomonas...
The main route of the transmission SARS-CoV-2 virus is through airborne small aerosol particles containing viable as well droplets transmitted between people within close proximity. Transmission via contaminated surfaces has also been recognized an important for spread coronavirus. Among a variety antimicrobial agents currently in use, polymers represent class biocides that have become increasingly alternative to existing biocidal approaches. Two transparent polymeric compounds, silver and...
The recent attention to the risk of potential permanent eye damage triggered by ocular infections has been leading a deeper investigation current antimicrobials. An antimicrobial agent used in ophthalmology should possess following characteristics: broad spectrum, prompt action even presence organic matter, and nontoxicity. objective this study is compare efficacy widely ophthalmic antiseptics containing povidone-iodine, chlorhexidine, liposomes ozonated sunflower oil. We determined minimum...
Abstract Late‐onset Intrauterine growth restriction (IUGR) refers to impaired and development of the fetus, characterized by placental morphological abnormalities that affect fetus's supply nutrients. Human leukocyte antigen‐G (HLA‐G) is physiologically expressed during pregnancy, but decreased in normal placenta last weeks gestation possibly inducing childbirth. Several viruses involved congenital infection, such as herpesviruses, exploit HLA‐G expression an immune‐escape mechanism. To...
Background: The infection and negative effects of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus) virus are mitigated by vaccines. It is unknown whether vaccination has worked eliciting robust protective innate immune responses with high affinity. Methods: Twenty healthy volunteers received three doses Comirnaty (Pfizer Australia Pty Ltd.) were evaluated 9 months after second 1 month booster dose. exclusion criteria presence adverse following vaccination, a history smoking,...
Natural Killer (NK) cells are key effectors of the innate immune system which represent first line defense against viral infections. NK cell activation depends on engagement a complex receptor repertoire expressed their surface, consisting both activating and inhibitory receptors. Among known receptors, family killer Ig-like receptors (KIRs) consists in activating/inhibitory that interact with specific human leukocyte antigen (HLA) molecules target cells. In particular, expression peculiar...
A number of studies have suggested that human herpesvirus 6A (HHV-6A) may play a role in multiple sclerosis (MS). Three possible hypotheses been investigated: (1) U24 from HHV-6A (U24-6A) mimics myelin basic protein (MBP) through analogous phosphorylation and interaction with Fyn-SH3; (2) U24-6A affects endocytic recycling by binding neural precursor cell (NPC) expressed developmentally down-regulated 4-like WW3* domain (hNedd4L-WW3*); (3) MS patients who express Killer Cell Immunoglobulin...
Background: A neuroinflammatory disease such as Alzheimer’s disease, presents a significant challenge in neurotherapeutics, particularly due to the complex etiology and allostatic factors, referred CNS stressors, that accelerate development progression of disease. These stressors include cerebral hypo-glucose metabolism, hyperinsulinemia, mitochondrial dysfunction, oxidative stress, impairment neuronal autophagy, hypoxic insults neuroinflammation. This study aims explore efficacy safety...
In multiple sclerosis (MS), there is a possible relationship with viral infection, evidenced by clinical evidence of an implication infectious events disease onset and/or relapse. The aim this research to study how human herpesvirus (HHVs) infections might dysregulate the innate immune system and impact autoimmune responses in MS. We analyzed 100 MS relapsing remitting patients, remission phase, healthy controls subjects other inflammatory neurological diseases (OIND) (neuro-lupus) for their...
Vaccines against SARS-CoV-2 ameliorate infection and adverse outcomes from SARS-CoV-2. Elicitation of high affinity durable protective antibody responses is a hallmark successful humoral immune response to vaccination. To assess the relevance serum levels specific antibodies further characterize vaccines, we report i) spike-binding neutralizing SARS-COV-2 in sera 30 healthy volunteers at nine months after second vaccination dose mRNA vaccine one month booster dose; ii) IFN-γ production by...
Abstract KIR2DL2, an inhibitory Killer cell Immunoglobulin-like Receptor (KIR), has been shown to predispose the development of several herpesvirus-associated diseases by inhibiting efficiency Natural (NK) cells against virus-infected cells. The aim this observational study was assess prevalence KIR2DL2 and Human Herpes Virus 8 (HHV8) in patients affected with classical endemic Kaposi sarcoma (KS), as well controls. Blood samples collected from 17 Caucasian, HIV-negative, immunocompetent KS...