A5061201808- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Hematological disorders and diagnostics
- Viral-associated cancers and disorders
- Acute Lymphoblastic Leukemia research
- Multiple Myeloma Research and Treatments
- Tuberculosis Research and Epidemiology
- Lung Cancer Treatments and Mutations
- Blood disorders and treatments
- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Neutropenia and Cancer Infections
- Chronic Lymphocytic Leukemia Research
- Complementary and Alternative Medicine Studies
- Organ and Tissue Transplantation Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Myasthenia Gravis and Thymoma
- Immune Cell Function and Interaction
- Lymphadenopathy Diagnosis and Analysis
- Childhood Cancer Survivors' Quality of Life
- Organ Transplantation Techniques and Outcomes
Groote Schuur Hospital
2019-2025
University of Cape Town
2018-2025
Mater Misericordiae University Hospital
2014-2016
Mater Misericordiae Hospital
2014
KU Leuven
2003-2013
Universitair Ziekenhuis Leuven
2002
Background: Extrapulmonary tuberculosis (EPTB) is common among people living with HIV (PLWH). Abdominal ultrasound an accessible investigation, frequently employed to support the diagnosis of EPTB, but may lead misdiagnoses diseases overlapping clinical features, such as lymphoma.Objectives: To describe abdominal features and confirmed diagnoses patients referred a biopsy clinic unexplained lymphadenopathy.Method: This was retrospective descriptive study attending peripheral lymph node at...
Background. Primary immune thrombocytopenia (ITP) is an acquired autoimmune disease characterised by isolated of <100 × 109/L in the absence identifiable secondary causes. Treatment indicated when platelet count <20 - 30 109/L, but may be commenced at higher counts risk bleeding high. Corticosteroids are backbone initial treatment ITP. There a paucity data South Africa (SA) on outcomes newly diagnosed ITP patients treated with corticosteroids. Objectives. To describe response,...
Abstract Background: Epstein-Barr virus (EBV) infection is an established causal factor for Hodgkin lymphoma (HL). MicroRNAs (miRNAs) are master regulators of gene expression and ideal biomarkers. We profiled the circulating 42 EBV miRNAs in HL patients to determine if miRNA(s) can be a noninvasive biomarker EBV+ or disease severity. Method: Plasma was obtained from 11 with tuberculosis HIV-endemic setting Cape Town, South Africa. tumor cells were confirmed using clinical PCR assay. The...
Abstract Background The WHO recently recommended the new Xpert MTB/RIF Ultra assay (Ultra) instead of because has improved sensitivity. We report diagnostic accuracy for tuberculous adenitis in a tuberculosis and HIV endemic setting. Methods obtained fine-needle aspirates (FNA) lymph node tissue by core-needle biopsy adult patients with peripheral lymphadenopathy >20 mm. mycobacterial culture were performed on FNA specimens, histological examination specimens. assessed against composite...
Abstract Medical professionals, particularly in regions with a high burden of human immunodeficiency virus (HIV), should be alert to the hematological complications HIV, which may include cytopenias, malignancy, and coagulation disturbances. Patients present these conditions as first manifestation HIV infection. Hematological abnormalities are often multifactorial opportunistic infections, drugs, infection itself contributing clinical presentation, diagnosis consider all factors....
The most recent and powerful prognostic instrument established for myelodysplastic syndromes (MDS) is the International Prognostic Scoring System (IPSS), which primarily based on medullary blast cell count, number of cytopenias, cytogenetics. Although this system has substantial predictive power in MDS, further refinement necessary, especially as far lower-risk patients are concerned. Histologic parameters, have long proved to be associated with outcome, promising candidates improve accuracy...
Little is known about the pathway to diagnosis of lymphoma in Sub-Saharan Africa, despite increased risk people living with HIV (PLHIV). The challenges this setting include diagnostic confusion extrapulmonary tuberculosis (EPTB), which commonly causes lymphadenopathy PLHIV. We analysed time and treatment patients using predetermined intervals. Univariate multivariable analyses were performed determine relationship between patient disease-specific variables delays diagnosis. particularly...
For more than 70 years the default therapy for anaemia and blood loss was mostly transfusion. Accumulating evidence demonstrates a significant dose-dependent relationship between transfusion adverse outcomes. This other transfusion-related challenges led way to new paradigm. Patient management (PBM) is application of evidence-based practices optimise patient outcomes by managing preserving patient's own blood. 'Real-world' studies have shown that PBM improves saves money. The prevalence in...
Myeloma bone disease (MBD) is a major cause of morbidity in multiple myeloma (MM). We investigated turnover markers (BTM) as relapse predictors and biomarkers for monitoring MBD. measured C-terminal telopeptide type I collagen (CTX-1), Procollagen 1 N Propeptide (P1NP) 86 MM patients 26 controls. CTX-1 was higher newly diagnosed compared to control, remission (P < 0·05), decreased following treatment. In the setting relapse, rise greater than calculated least significant change (LSC)...
Infectious disease epidemics may overshadow and exacerbate existing challenges in diagnosing lymphoma. We describe pragmatic strategies we have implemented to overcome diagnostic obstacles caused by the local tuberculosis (TB) HIV South Africa, which serve as a guide minimize delay during COVID-19 pandemic. report on utility of rapid-access lymph node core-biopsy clinic, where biopsies are taken from outpatients at their first visit. Analysis tissue (n = 110) revealed three most common...
Lymphadenopathy is a common presenting complaint, or it may be an incidental finding during examination of patient. This review focuses on the diagnostic difficulty, misconceptions and tests that can applied in investigation lymphadenopathy. A approach suggested with regard to most important causes peripheral, persistent (>3 weeks) significant (>1 cm) lymphadenopathy, i.e. tuberculosis, lymphoma disseminated malignancy.