A5025236447- Parkinson's Disease Mechanisms and Treatments
- Ubiquitin and proteasome pathways
- Alzheimer's disease research and treatments
- Signaling Pathways in Disease
- Autophagy in Disease and Therapy
- Genetics and Neurodevelopmental Disorders
- NF-κB Signaling Pathways
- Endoplasmic Reticulum Stress and Disease
- Down syndrome and intellectual disability research
- Peptidase Inhibition and Analysis
- Nuclear Receptors and Signaling
- RNA regulation and disease
- 14-3-3 protein interactions
- Neuroscience and Neuropharmacology Research
- Galectins and Cancer Biology
- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- interferon and immune responses
- Histone Deacetylase Inhibitors Research
- Cellular transport and secretion
- Cancer-related Molecular Pathways
- biodegradable polymer synthesis and properties
- Heat shock proteins research
- Trace Elements in Health
- Glycosylation and Glycoproteins Research
Yonsei University
2014-2024
Google (United States)
2016
Benha University
2016
Seoul National University
2004-2006
Inha University
2002-2004
University of Baltimore
2001
University of Maryland, Baltimore
2001
Northwestern University
1995
Mucin hypersecretion is commonly observed in many inflammatory diseases of the respiratory tract. MUC5AC generally recognized to be a major airway mucin because highly expressed goblet cells human epithelium. Moreover, it regulated by various cytokines. However, mechanisms which interleukin (IL)-1β and tumor necrosis factor (TNF)-α induce gene expression normal nasal epithelial cells, signal molecules involved, especially downstream signaling mitogen-activated protein (MAP) kinases, remain...
The presynaptic α-synuclein is a prime suspect for contributing to Lewy pathology and clinical aspects of diseases, including Parkinson's disease, dementia with bodies, body variant Alzheimer's disease. Here we examined the pathogenic mechanism neuronal cell death induced by α-synuclein. exogenous addition caused marked decrease viability in primary immortalized cells. appeared be correlated Rab5A-specific endocytosis that subsequently formation body-like intracytoplasmic inclusions. This...
Down syndrome (DS) is associated with many neural defects, including reduced brain size and impaired neuronal proliferation, highly contributing to the mental retardation. Those typical characteristics of DS are closely a specific gene group "Down critical region" (DSCR) on human chromosome 21. Here we investigated molecular mechanisms underlying proliferation in and, more specifically, regulatory role for dual-specificity tyrosine-(Y) phosphorylation-regulated kinase 1A (Dyrk1A), DSCR...
The proto-oncogene c-Myc has a pivotal function in growth control, differentiation, and apoptosis is frequently affected human cancer, including breast cancer. Ubiquitin-specific protease 22 (USP22), member of the USP family deubiquitinating enzymes (DUBs), mediates deubiquitination target proteins, histone H2B H2A, telomeric repeat binding factor 1, cyclin B1. USP22 also component mammalian SAGA transcriptional co-activating complex. In this study, we explored functional role modulating...
Other SectionsABSTRACTINTRODUCTIONTHE UPS AND AUTOPHAGY ARE TIGHTLY ASSOCIATEDTHE MAIN CONNECTOR BETWEEN THE AUTOPHAGY, p62, ALSO REGULATES THEIR CROSSTALKTHE CENTRAL ROLE OF p62 IN MITOPHAGY PROGRESSION PARKINSON’S DISEASECONCLUSIONACKNOWLEDGEMENTSCONFLICTS INTERESTFIGURESTABLEREFERENCES
Dyrk is a dual specific protein kinase thought to be involved in normal embryo neurogenesis and brain development. Defects/imperfections this have been suggested play an important role the mental retardation of patients with Down's syndrome. The transcriptional factor cAMP response element-binding (CREB) has implicated formation many types synaptic plasticity, such as learning memory. In present study we show that Dyrk1 activity markedly induced during differentiation immortalized...
Abstract α‐Synuclein (α‐syn) has been known to be a key player of the pathogenesis Parkinson’s disease and recently detected in extracellular biological fluids shown rapidly secreted from cells. The penetration α‐syn into cells also observed. In this study, we observed that dl ‐threo‐1‐phenyl‐2‐decanoylamino‐3‐morpholino‐1‐propanol, glucosyltransferase inhibitor, proteinase K inhibited internalization monomeric BV‐2 cells, addition monosialoganglioside GM1 ameliorated inhibition...
Abstract Many lines of evidence suggest that α‐synuclein can be secreted from cells and penetrate into them, although the detailed mechanism is not known. In this study, we investigated amino acid sequence motifs required for membrane translocation α‐synuclein, mechanistic features phenomenon. We first showed only but also β‐ γ‐synucleins penetrated live cells, indicating conserved N‐terminal region might responsible translocation. Using a series deletion mutants, demonstrated 11‐amino...
α-Synuclein has been implicated in the pathogenesis of many neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. Although function α-synuclein remains largely unknown, recent studies have demonstrated that this protein can interact with phospholipids. To address role disease, we investigated whether it binds phospholipase D (PLD) affects PLD activity human embryonic kidney (HEK)-293 cells overexpressing wild type or mutant forms (A53T, A30P) associated Tyrosine...
Recent studies have provided evidence that Zn 2+ plays a crucial role in ischemia‐ and seizure‐induced neuronal death. However, the intracellular signaling pathways involved ‐induced cell death are largely unknown. In present study, we investigated roles of mitogen‐activated protein kinases (MAPKs), such as c‐Jun N‐terminal kinase (JNK), p38 MAPK extracellular signal‐regulated (ERK), reactive oxygen species (ROS) using differentiated PC12 cells. Intracellular accumulation induced by combined...
Lewy bodies (LBs) are pathological hallmarks of Parkinson disease (PD) but also occur in Alzheimer (AD) and dementia LBs. Alpha-synuclein, the major component LBs, is observed brain Down syndrome (DS) patients with AD. Dyrk1A, a dual specificity tyrosine-regulated kinase (Dyrk) family member, mammalian ortholog Drosophila minibrain (Mnb) gene, essential for normal postembryonic neurogenesis. The Dyrk1A gene resides human chromosome 21q22.2 region, which associated DS anomalies, including...
Abstract Parkinson disease (PD) is the second most common neurodegenerative disorder and characterized by extensive progressive loss of dopaminergic neurons in CNS substantia nigra pars compacta region. Mutations parkin gene, which encodes for E3 ubiquitin ligase, have been implicated autosomal recessive juvenile parkinsonism, an early‐onset familial form PD. Although several substrates already identified, molecular mechanism underlying regulation enzymatic activity has yet to be clarified....
Parkinson disease (PD) is a common neurodegenerative disorder, which involves the deterioration of dopaminergic neurons in pars compacta substantia nigra. The etiology PD still unknown, but recent identification mutations familial cases has advanced understanding molecular mechanisms this neurological disease. Mutations parkin gene, encodes for ubiquitin-protein ligase (E3), have been implicated autosomal recessive juvenile Parkinsonism, an early onset and form PD. Here we reported that...
Neuronal L-type Ca2+ channels do not support synaptic transmission, but they play an essential role in activity-dependent gene expression. Cav1.2 and Cav1.3 are the two most widely expressed neurons have different biophysical subcellular distributions. The function of Cav 1.3 channel its cellular mechanisms central nervous system poorly understood. In this study, using a yeast two-hybrid assay, we found that N terminus rat α1 subunit interacts with partial N-terminal amino acid sequence...
Parkinson's disease (PD) is a common neurodegenerative that involves the deterioration of dopaminergic neurons in substantia nigra pars compacta. Although etiology PD remains poorly understood, recent genetic, postmortem, and experimental evidence shows abnormal protein accumulation subsequent aggregate formation are prominent features both sporadic familial PD. While proteasome dysfunction observed PD, diverse mutations parkin gene linked to early-onset autosomal-recessive forms We...
Leucine-rich repeat kinase 2 (LRRK2) is a gene in which mutation causes Parkinson's disease (PD), and p53 prototype tumor suppressor. In addition, activation of patient with PD has been reported by several studies. Because phosphorylation critical for regulating its activity LRRK2 kinase, we tested whether phosphorylated LRRK2. phosphorylates threonine (Thr) at TXR sites an vitro assay, the T304 T377 were identified as putative residues. An increase phospho-Thr motif was confirmed cells...
While Parkinson's disease (PD) is predominantly sporadic, various mutations in the PTEN-induced putative kinase 1 (PINK1) gene have been linked to autosomal recessive form of PD. PINK1, a serine/threonine protein kinase, holds pivotal role mitophagy - process that selectively eliminates damaged mitochondria, overseeing mitochondrial quality control and ultimately safeguarding against neuronal cell loss Understanding regulation PINK1 stability essential comprehending PD pathology, given its...
α-Synuclein is a pathological component of Parkinson's disease by constituting the filamentous Lewy bodies. Phthalocyanine (Pc) effects on amyloidosis α-synuclein have been examined. The copper complex phthalocyanine tetrasulfonate (PcTS−Cu2+) caused self-oligomerization while Pc−Cu2+ did not affect protein, indicating that introduction sulfonate groups was critical for selective protein interaction. PcTS−Cu2+ interaction with has occurred predominantly at N-terminal region Kd 0.83 μM apart...