Finasteride, a 5α-reductase inhibitor, is marketed in low dose (1 mg) as popular therapy for androgenic alopecia young men. As case reports and small surveys have suggested link between persistent sexual dysfunction (SD) suicidal ideation (SI) with low-dose finasteride, the aim of this study was to detect signals SD SI secondary finasteride use men.Retrospective pharmacovigilance disproportionality analysis.United States Food Drug Administration Adverse Event Reporting System (FAERS)...

Purpose: To identify the characteristics and initial disease severity of patients with nonalcoholic fatty liver (NAFLD) assess incidence risk factors for progression in a retrospective study. Methods: Patients ≥18 years age without alcoholism or other diseases (eg, hepatitis B/C) were selected from Geisinger Health System electronic medical record data 2004 to 2015. Initial stage was stratified into uncomplicated NAFLD, advanced fibrosis, cirrhosis, hepatocellular carcinoma (HCC), transplant...

To characterize select laboratory tests ordered versus reported for patients diagnosed with COVID-19 in administrative healthcare and commercial data. Among an outpatient diagnosis claim HealthVerity data (01/01/2021-12/31/2022), this study described baseline characteristics descriptively compared SARS-CoV-2 diagnostic liver function from (insurance claims hospital billing data) laboratories, overall by code type (e.g., CPT, LOINC). Select were also method-specific methodless LOINC. 214 998...

Background: Omalizumab is a monoclonal antibody, indicated for the treatment of severe allergic asthma. In Europe, there have been concerns about cardiovascular safety omalizumab. The objective this study was to analyze association between omalizumab and arterial thrombotic events in spontaneous adverse drug reaction reporting database US. Methods materials: Reports submitted US Food Drug Administration's Adverse Event Reporting System (AERS) 2004 2011 were retrieved analyzed by odds ratio...

Ipilimumab, pembrolizumab, and nivolumab are checkpoint inhibitors (CPIs) that activate T-cell-mediated immune response. CPI can provide durable benefits to some cancer patients with melanoma, renal cell cancer, non-small lung or a growing list of other cancers. However, treatment is also associated adverse immune-mediated reactions (IMRs) be life-threatening. This pharmacovigilance analysis aims characterize IMR signals in relation treatment.Retrospective disproportionality analysis.U.S....

Background: The purpose of this study was to examine the postmarketing safety profile aliskiren hemifumarate, a first-in-class direct renin inhibitor. Methods: US Adverse Event Reporting System (AERS) utilized conduct retrospective pharmacovigilance analysis by applying Multi-item Gamma Poisson Shrinker data mining algorithm calculate empiric Bayes geometric mean (EBGM) values aliskiren-related adverse event reports. Reports received from January 2007 through December 2008 are included in...

Objective To compare real-world effectiveness and safety of direct oral anticoagulants (DOACs) in patients with nonvalvular atrial fibrillation (AFib) for prevention stroke. Study design setting A comparative cohort study UK general practice data from The Health Improvement Network database. Participants interventions Before matching, 5655 ≥18 years AFib who initiated at least one DOAC between 1 July 2014 31 December 2020 were included. DOACs interest included apixaban, rivaroxaban, edoxaban...

A number of risk factors have been recognised for postoperative renal dysfunction following on-pump coronary artery bypass surgery (CABG). There are, however, few studies that evaluated the potential reno-protective effects off-pump CABG in presence other confounding factors. The aim this study was to determine if reduces injury.Serum creatinine values (preoperatively and day 1, 2 4 postoperatively) clinical data were prospectively collected on 1580 consecutive patients who underwent...

BACKGROUND: Diabetes is a leading cause of morbidity, mortality, and medical resource utilization in the United States worldwide. Treatment aimed at keeping blood glucose levels close to normal preventing or delaying complications. It has been estimated that only 50% patients with diabetes achieve glycosylated hemoglobin A1c level < 7%. Nonadherence antidiabetic medications identified as major factor related poor glycemic control. OBJECTIVES: To (a) assess adult type 2 mellitus (T2DM) whose...

BACKGROUND: Hypoglycemia is a major limiting factor in achieving glycemic control persons with diabetes. In some instances, recovery from severe hypoglycemia event may require health care resource utilization (HCRU), including the use of emergency medical services (EMS), visits to department (ED), and inpatient hospitalization. OBJECTIVES: To (a) describe profiles patients who experience hypoglycemic events (b) characterize HCRU associated cost related treatment. METHODS: This retrospective,...

Evidence suggests that insulin therapy of patients with type 2 diabetes mellitus (T2DM) is frequently discontinued. However, the reasons for discontinuing and factors associated discontinuation in this patient population are not well understood. We conducted a retrospective cohort study adults T2DM prescribed between 2010 2017 at Partners HealthCare. Reasons were studied using electronic medical records (EMR) data. Natural language processing (NLP) was applied to identify from unstructured...

Pharmacoepidemiology is the science of studying effects utilizing pharmaceutical and biological products in population, most cases this conducted observational epidemiological designs, including retrospective database analysis. Observational pharmacoepidemiology associated with a myriad methodological challenges that affect study conclusions related causal inferences. However, if these are addressed effectively dealt with, studies can have important impactful clinical, regulatory, public...

Many individuals with developmental or intellectual and other disabilities are on waitlists to receive supportive services through state Medicaid waiver programs. Being waitlisted can place considerable burden the ability of a caregiver maintain employment outside home. This article reports results survey 442 caregivers for within Florida program. Logistic regression was used model characteristics clients that associated need additional supports in order employment. Male fair poor health...

Markers of hepatitis A and B virus were tested in 88 adult Sudanese subjects Khartoum, Sudan. The consisted 25 control hospitalized patients, 21 volunteer blood donors, 23 patients with hepatosplenic schistosomiasis, 13 liver cirrhosis 6 hepatocellular carcinoma (HCC). Antibody to was detected 96% the total. Hepatitis surface antigen (HBsAg) positive 4, 24, 22, 31, 67% subject groups, respectively. against core (HBcAb) undiluted serum 60, 57, 65, 77 83%, there no difference incidence among...

The epidemiology of Bile duct and gallbladder disease (BDGD) in patients with diabetes mellitus (DM) is not well characterized. Records enrolled U.S. Truven Health MarketScan database between 2015-2016 were analyzed to estimate the incidence prevalence rates BDGD among DM. Rates stratified by age, gender, DM type (T1D T2D), compared general population. Diagnosis procedure codes for cholelithiasis, cholecystitis, cholangitis, other biliary disorders (excluding neoplasms, congenital, pregnancy...

Aims: Roflumilast is a phosphodiesterase-4-inhibitor used as add-on therapy to long-acting bronchodilators in chronic obstructive pulmonary disease. Although roflumilast well tolerated, there have been concerns regarding psychiatric problems, including suicide tendencies. This study aims identify and characterize signals of adverse events reported for the US FDA Adverse Event Reporting System (FAERS). Study Design: Retrospective pharmacovigilance analysis. Place Duration Study: event reports...

Cumulative investigations have depicted that metabolic rate of some trace elements has altered in diabetes. This study is designed to illustrate the consequence element copper (Cu), iron (Fe), Cobalt (Co), zinc (Zn) and Zn/Cu ratio) diabetic female patients with mellitus type 2 (n=60), 1 (n=69) as compared nondiabetic control subjects (n=35). The levels recorded by an atomic absorption spectrophotometer. consequences this paper mean magnitudes Zn, Cu, addition Fe significantly lessened...