A5015053939- Graphene research and applications
- Quantum and electron transport phenomena
- Topological Materials and Phenomena
- Immune Cell Function and Interaction
- Physics of Superconductivity and Magnetism
- T-cell and B-cell Immunology
- Molecular Junctions and Nanostructures
- HIV Research and Treatment
- Immunotherapy and Immune Responses
- Cellular transport and secretion
- Quantum, superfluid, helium dynamics
- Bacterial biofilms and quorum sensing
- Biochemical and Structural Characterization
- Cold Atom Physics and Bose-Einstein Condensates
- Membrane Separation and Gas Transport
- 2D Materials and Applications
- Electrostatics and Colloid Interactions
- Advanced Physical and Chemical Molecular Interactions
- Muon and positron interactions and applications
- Invertebrate Immune Response Mechanisms
- Cancer Immunotherapy and Biomarkers
- Advanced Thermodynamics and Statistical Mechanics
- Bioinformatics and Genomic Networks
- vaccines and immunoinformatics approaches
- Escherichia coli research studies
The University of Texas at Austin
2023-2025
TH Köln - University of Applied Sciences
2021-2024
Leibniz University Hannover
2022-2024
Università della Svizzera italiana
2016-2023
ETH Zurich
2016-2022
Technical University of Munich
2019
Osnabrück University
2006
Metabolic activity is intimately linked to T cell fate and function. Using high-resolution mass spectrometry, we generated dynamic metabolome proteome profiles of human primary naive cells following activation. We discovered critical changes in the arginine metabolism that led a drop intracellular L-arginine concentration. Elevating levels induced global metabolic including shift from glycolysis oxidative phosphorylation activated promoted generation central memory-like endowed with higher...
Lightly doped multilayer graphene surprised researchers with the emergence of superconductivity and magnetism under strong electric displacement fields. The authors interpret field versus hole-density phase diagram using mean-field theory experimentally informed band structure. They find that in these electronic systems is often intertwined nematic order because noncompact Fermi sea topology fourfold spin-valley degeneracy.
Twisted graphene bilayers provide a versatile platform to engineer metamaterials with novel emergent properties by exploiting the resulting geometric moir\'e superlattice. Such superlattices are known host bulk valley currents at tiny angles ($\ensuremath{\alpha}\ensuremath{\approx}0.3\ifmmode^\circ\else\textdegree\fi{}$) and flat bands magic ($\ensuremath{\alpha}\ensuremath{\approx}1\ifmmode^\circ\else\textdegree\fi{}$). We show that tuning twist angle...
We employ a functional renormalization group approach to ascertain the pairing mechanism and symmetry of superconducting phase observed in rhombohedral trilayer graphene. Superconductivity this system occurs regime carrier density displacement field with weakly distorted annular Fermi sea. find that repulsive Coulomb interactions can induce electron on surface by taking advantage momentum-space structure associated finite width sea annulus. The degeneracy between spin-singlet spin-triplet is...
Superlattice potential modulation can produce flat minibands in Bernal-stacked bilayer graphene.In this work we study how band topology and interaction-induced symmetry-broken phases system are controlled by tuning the displacement field shape strength of superlattice potential.We use an analytic perturbative analysis to demonstrate that topological bands favored a honeycomb-lattice-shaped potential, numerics show robustness depends on both periodicity potential.At integer fillings bands,...
Alzheimer's disease (AD) is characterized by progressive loss of neurons in selected brain regions, extracellular accumulations amyloid beta, and intracellular fibrils containing hyperphosphorylated tau. Tau mutations familial tauopathies confirmed a central role tau pathology; however, the alteration sequence tau-dependent neurodegeneration AD remain elusive. Using Sindbis virus-mediated expression AD-relevant constructs hippocampal slices, we show that disease-like modifications affect...
The antigen density on the surface of HIV-based virus-like particles (VLPs) plays a crucial role in improvement HIV vaccine potency. VLPs consist dense protein core, which is surrounded by lipid bilayer and whose usually decorated with antigenic glycoproteins. successful downstream processing these challenging, high-resolution cost-efficient purification has not yet been achieved. Chromatography, one major unit operations involved VLP strategies, carried out means ion exchangers or...
The low-energy collective excitations of semiconductors and insulators often couple strongly to light, allowing them be probed optically. We argue here that in fractional Chern intraband are dark the sense they anomalously weakly light. Using this property, we establish a general relationship between flat-band numbers, quantum geometry, spatial correlations fractional-Chern-insulator states.
Significance New imaging-based approaches are incorporating new concepts to our knowledge of biological processes. The analysis receptor dynamics involved in cell movement using single-particle tracking demonstrates that cells require chemokine-mediated clustering sense appropriately chemoattractant gradients. Here, we report this process does not occur T expressing CXCR4 R334X , a mutant form linked WHIM syndrome (warts, hypogammaglobulinemia, infections, myelokathexis). underlaying...
Van der Waals heterostructures provide a rich platform for emergent physics due to their tunable hybridization of layers, orbitals, and spin. Here, we find that twisted bilayer graphene stacked between antialigned ferromagnetic insulators can feature flat electronic bands the interplay twist, exchange proximity, spin--orbit coupling. These are nearly degenerate in valley only effectively described by triangular superlattice model. At half filling, interactions induce spontaneous correlations...
Elucidating the mechanisms by which immune cells become dysfunctional in tumors is critical to developing next-generation immunotherapies. We profiled proteomes of cancer tissue as well monocyte/macrophages, CD4+ and CD8+ T cells, NK isolated from tumors, liver, blood 48 patients with hepatocellular carcinoma. found that tumor macrophages induce sphingosine-1-phospate-degrading enzyme SGPL1, dampened their inflammatory phenotype anti-tumor function vivo. further discovered signaling scaffold...
Lectins are glycan-binding proteins with no catalytic activity and ubiquitously expressed in nature. Numerous bacteria use lectins to efficiently bind epithelia, thus facilitating tissue colonisation. Wounded skin is one of the preferred niches for Pseudomonas aeruginosa , which has developed diverse strategies impair repair processes promote infection. Here, we analyse effect P. fucose-binding lectin LecB on human keratinocytes demonstrate that it triggers events host, upon binding...
HIV Gag virus-like particles (HIV VLPs) are promising vaccine candidates. In the literature, they often described as shear-sensitive particles, and authors usually recommend operation of tangential flow filtration (TFF) gently at shear rates below 4,000 s −1 to 6,000 . This in turn poses a severe limitation performance TFF-mediated concentration VLPs, which would be substantially enhanced by working higher rates. To our knowledge, studies examining sensitivity VLPs providing detailed...
We report the successful adaptation of quasi-boson approximation, a technique traditionally employed in nuclear physics, to analysis two-dimensional electron gas. show that correlation energy estimated from this approximation agrees closely with results obtained quantum Monte Carlo simulations. Our methodology comprehensively incorporates exchange self-energy, direct scattering, and scattering for particle-hole pair excited out mean-field ground state within equation-of-motion framework. The...
The main scope of this work is to develop nano-carbon-based mixed matrix cellulose acetate membranes (MMMs) for the potential use in both gas and liquid separation processes. For purpose, a variety membranes, consisting (CA) polymer carbon nanotubes as additive material were prepared, characterized, tested. Multi-walled (MWCNTs) used filler diacetone alcohol (DAA) solvent. first objective towards highly efficient composite was proper preparation agglomerate-free MWCNTs dispersions....
The authors show that competing electronic interactions in a doped Dirac material lead to multiorbital non-unitary superconducting state, stemming from the interplay between charge-density-wave and orders.
Emerging as a promising pathway to HIV vaccines, Virus-Like Particles (VLPs) have drawn considerable attention in recent years. A challenge of working with VLPs biopharmaceutical processes is their low rigidity, and factors such shear stress, osmotic pressure pH variation be reduced during production. In this context, the purification concentration are often achieved by means Tangential Flow Filtration (TFF) involving ultrafiltration hollow fiber modules. Despite urgent need for robust...
The honeycomb lattice sets the basic arena for numerous ideas to implement electronic, photonic, or phononic topological bands in (meta-)materials. Novel opportunities manipulate Dirac electrons graphene through band engineering arise from superlattice potentials as induced by a substrate such hexagonal boron-nitride. Making use of general form weak potential dictated symmetry, we analytically derive low-energy minibands superstructure, including characteristic 1.5 cone deriving three-band...
In this work, supported cellulose acetate (CA) mixed matrix membranes (MMMs) were prepared and studied concerning their gas separation behaviors. The dispersion of carbon nanotube fillers as a factor polymer filler concentrations using the mixing methods rotor-stator system (RS) three-roll-mill (TRM). Compared to quality achieved by RS, samples TRM seem have slightly bigger, but fewer more homogenously distributed, agglomerates. green γ-butyrolactone (GBL) was chosen polyimide (PI)...
Tunneling spectroscopy of one-dimensional interacting wires can be profoundly sensitive to the boundary conditions wire. Here, we analyze tunneling a wire coupled capacitive metallic leads. Strikingly, with increasing many-body interactions in wire, impact noise becomes more prominent. This interplay allows for smooth crossover from standard 1D signatures into regime where is dominated by fluctuations at characterized an elevated zero-bias alongside universal power-law decay high energies....
Automated Fiber Placement allows the automated lay-up of tailored laminates in aerospace quality. For thermoplastic matrix materials, use closed-loop temperature control enables an situ consolidation. This makes autoclave curing superfluous and increases overall process efficiency. Scientific sounding rockets typically consist several aluminum modules carrying scientific payload. The design a module includes cylindrical outer shell two load input rings with defined assembly interface....