A5072242391- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Virus-based gene therapy research
- Immune cells in cancer
- Immune Cell Function and Interaction
- Lung Cancer Diagnosis and Treatment
- Amino Acid Enzymes and Metabolism
- Sphingolipid Metabolism and Signaling
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- CAR-T cell therapy research
Università della Svizzera italiana
2021-2023
Ludwig-Maximilians-Universität München
2023
Elucidating the mechanisms by which immune cells become dysfunctional in tumors is critical to developing next-generation immunotherapies. We profiled proteomes of cancer tissue as well monocyte/macrophages, CD4+ and CD8+ T cells, NK isolated from tumors, liver, blood 48 patients with hepatocellular carcinoma. found that tumor macrophages induce sphingosine-1-phospate-degrading enzyme SGPL1, dampened their inflammatory phenotype anti-tumor function vivo. further discovered signaling scaffold...
Abstract The availability of L-arginine in tumors is a key determinant an efficient anti-tumor T cell response. Consequently, elevation typically low levels within the tumor may greatly potentiate responses immune checkpoint inhibitors, such as PD-L1 blocking antibodies. However, currently no means are available to locally increase intra-tumoral levels. Here, we used synthetic biology approach develop engineered probiotic Escherichia coli Nissle 1917 strain that colonizes and continuously...