Changkun Pan

ORCID: 0000-0003-4666-0699
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About
Contact & Profiles
Research Areas
  • Invertebrate Immune Response Mechanisms
  • Insect symbiosis and bacterial influences
  • Mosquito-borne diseases and control
  • Developmental Biology and Gene Regulation
  • Neurobiology and Insect Physiology Research
  • Genetics, Aging, and Longevity in Model Organisms
  • Signaling Pathways in Disease
  • Marine Ecology and Invasive Species
  • Circular RNAs in diseases
  • Cancer-related molecular mechanisms research
  • Protist diversity and phylogeny
  • Aquaculture Nutrition and Growth
  • MicroRNA in disease regulation
  • Plant Molecular Biology Research
  • Physiological and biochemical adaptations
  • Aquaculture disease management and microbiota
  • Studies on Chitinases and Chitosanases

Sichuan University
2021-2023

State Key Laboratory of Biotherapy
2021-2023

Minjiang University
2019

Fujian Institute of Oceanography
2016-2017

Ningbo University
2016-2017

Jiamusi University
2013

Sepiapterin reductase (Spr) plays an essential role in the biosynthesis of tetrahydrobiopterin (BH4), a key cofactor multiple enzymes involved various physiological and immune processes. Suppression Spr could result BH4 deficiency-caused diseases human murine models. However, information on biological function invertebrates is limited. In this study, two Sprs (CG12116 Sptr) from Drosophila melanogaster were found to be downregulated transgenic flies overexpressing white spot syndrome virus...

10.3389/fmicb.2021.796049 article EN cc-by Frontiers in Microbiology 2021-12-23

Drosophila melanogaster Down syndrome cell adhesion molecule 1 (Dscam1) encodes 19,008 diverse ectodomain isoforms via the alternative splicing of exon 4, 6, and 9 clusters. However, whether individual or clusters have specific significance is unclear. Here, using phenotype-diversity correlation analysis, we reveal redundant roles Dscam1 diversity in neuronal wiring. A series deletion mutations were performed from endogenous locus harboring clusters, reducing to 396 18,612 potential...

10.1371/journal.pbio.3002197 article EN cc-by PLoS Biology 2023-07-06

The paired box 6 (Pax6) gene encodes a transcription factor essential for eye development in wide range of animal lineages. Here we describe the cloning and characterization Pax6 from blind hydrothermal vent tubeworm Ridgeia piscesae (RpPax6). deduced RpPax6 protein shares extensive sequence identity with proteins other species contains both domain complete homeodomain. Phylogenetic analysis indicates that it clusters corresponding closely related Platynereis dumerilii (P. dumerilii)...

10.1371/journal.pone.0168579 article EN cc-by PLoS ONE 2016-12-22
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