A5062051078- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- Multiple and Secondary Primary Cancers
- Economic and Financial Impacts of Cancer
- Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Musculoskeletal pain and rehabilitation
- Inflammatory Biomarkers in Disease Prognosis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Bladder and Urothelial Cancer Treatments
- Estrogen and related hormone effects
- Colorectal and Anal Carcinomas
- Myofascial pain diagnosis and treatment
- Health, psychology, and well-being
- BRCA gene mutations in cancer
- Colorectal Cancer Screening and Detection
- Cancer survivorship and care
- Breast Lesions and Carcinomas
- Medication Adherence and Compliance
- Cancer Genomics and Diagnostics
- COVID-19 and healthcare impacts
- Global Cancer Incidence and Screening
- Lung Cancer Treatments and Mutations
EsSALUD
2017-2025
Instituto Nacional de Enfermedades Neoplásicas
2018-2019
Universidad Ricardo Palma
2019
Universidad de San Martín de Porres
2010-2019
The University of Texas MD Anderson Cancer Center
2019
Universidad Científica del Sur
2019
Despite osimertinib being the standard therapy for advanced EGFR T790M mutation positive NSCLC, in many Latin American countries, access to molecular testing and targeted therapies is limited, directly impacting patient outcomes. This study describes real-world management outcomes of Peruvian patients with EGFR-mutated NSCLC who develop mutation. We conducted a multicenter retrospective including from nine institutions, both public private, progressed first-line TKI developed mutation,...
Abstract Background: Adjuvant chemotherapy decreases the risk of recurrence and improves survival rates but it is unclear whether a delayed initiation associated with adverse outcomes. Information available especially scarce for triple negative breast cancer (TNBC) which represents high-risk group. We evaluated influence time to (TTC) on TNBC patient's Methods: retrospectively analyzed data using medical records patients who received adjuvant at Instituto Nacional de Enfermedades Neoplasicas...
Introducción: La fibromialgia es una entidad frecuente en la práctica clínica y se ha considerado que está asociada con desórdenes psiquiátricos, particular depresión, lo cual podría tener un impacto el tratamiento de esta entidad. Objetivo: Evaluar prevalencia síntomas depresivos pacientes fibromialgia. Diseño: Estudio observacional tipo transversal. Lugar: Servicio Reumatología, Hospital Departamental María Auxiliadora. Participantes: Pacientes ambos sexos diagnóstico Intervenciones: Se...
e20605 Background: Osimertinib is the standard of care for advanced NSCLC patients with EGFR T790M-positive whose disease has progressed to TKI therapy, however, knowledge on real benefit these therapies in Latin American setting remains unclear due lack access most countries. The aim this study evaluate outcomes as sencond line treatment a real-world Peruvian setting. Methods: This retrospective treated osimertinib at seven institutions between July 2018 and May 2023. Outcomes were...
e15644 Background: Colorectal cancer is a significant public health issue in Peru, and non-metastatic colorectal patients face numerous treatment challenges. Adherence to protocols has been identified as an important factor influencing patient outcomes. However, little known about the impact of adherence on overall survival Peru. The objective this study investigate association between population. Methods: We retrospectively reviewed electronic medical files 890 with non metastatic 2006...
e15180 Background: The incidence of colorectal cancer (CRC) in Peru has increased the last decades. In our population more than 80% patients are stage I-III. Recurrence is one most important factors to consider survival CRC patients. aim this study was identify which influence recurrence population. Methods: We retrospectively reviewed electronic medical records 506 with I-III from specialized Peruvian center between 2006 and 2016. Survival analysis (with as event evaluate) performed Kaplan...
e15617 Background: Colorectal cancer is a significant public health concern in Peru. Metastatic colorectal patients have limited treatment options, and the prognosis generally poor. In recent years, regimens for metastatic evolved significantly, with emergence of targeted therapies immunotherapy. However, little known about impact these on quality life overall survival Peruvian population. The objective this study to investigate association between (OS) patients. Methods: This retrospective...
548 Background: Oncotype Dx(ODX) prognosticates the risk of recurrence and predicts benefit adjuvant chemotherapy in estrogen-receptor-positive breast cancer (BC). However, its cost makes it prohibitive for many health care systems. Our objective is to develop a model using routine clinical pathological parameters estimate ODX high category guide decisions. Methods: We retrospectively reviewed pathology reports from 190 early BC patients (2014 2016) specialized center. Variables were...
e12011 Background: OncotypeDx(ODX) predicts the likelihood of estrogen receptor (ER) positive breast cancer (BC) recurrence and assesses likely benefit from both hormonal therapy chemotherapy. Many clinical scores that estimate risk category ODX are being tested. Ki67 is frequently incorporated into these assessments, although there no standard cut-off for its use. Methods: We retrospectively reviewed electronic medical files 190 patients with early stage ER+ BC whom score (RS) was available...
Abstract Background: The gene expression profiling assay OncotypeDx (ODX) predicts the likelihood of estrogen receptor (ER) positive breast cancer (BC) recurrence and assesses likely benefit from both hormonal therapy chemotherapy. Many clinical scores that estimate risk category ODX are being tested. Ki67 is frequently incorporated into these assessments, although there no standard cut-off for its use. Methods: We retrospectively reviewed electronic medical records 190 patients with early...
Abstract Background: Oncotype Dx (ODX) prognosticates the risk of recurrence and predicts benefit adjuvant chemotherapy in estrogen-receptor-positive breast cancer (BC). However, its cost makes it prohibitive for many health care systems. Our objective was to develop a model that uses routine clinical pathological parameters identify ODX high patients which require chemotherapy. Methods: We retrospectively reviewed pathology reports from 190 early BC treated between 2014 2016 specialized...
e15550 Background: High circulating neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte (PLR) appears to be prognostic in metastatic colorectal cancer (mCRC), they have been suggested as important inflammatory markers potential predictors of long-term outcomes patient with (CRC). Along another biomarkers, such RAS BRAF can facilitate the treatment decision making follow up these pts. The incidence CRC Peru has increasing, there is a lack data, especially on molecular features due its...
e15557 Background: Modified Glasgow Prognostic Score (mGPS), was reported as a good prognostic factor for OS, in other neoplasms, however its role mCRC it’s still being studied. High circulating neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte (PLR) appears to be metastatic colorectal cancer (mCRC), they have been suggested important inflammatory markers potential predictors of long-term outcomes patient with (CRC). In developing countries, the impact biomarkers that could better...
Abstract Background: The gene expression profiling assay OncotypeDx (ODx) prognosticates the risk of estrogen receptor positive (ER+) breast cancer (BC) recurrence and assesses likely benefit from adjuvant chemotherapy in addition to endocrine therapy. There have been several attempts develop algorithms that provide similar outcome prediction ODx with use routine clinicopathological characteristics. These models appear predict high-risk RS but are unable reliably rule out presence patients...
Abstract Background The gene expression profiling assay OncotypeDx (ODx) prognosticates the risk of estrogen receptor positive (ER+) breast cancer (BC) recurrence and assesses likely benefit from adjuvant chemotherapy in addition to endocrine therapy. There have been several attempts develop algorithms that provide similar outcome prediction ODx with use routine clinicopathological characteristics. Ki67 is frequently incorporated into these assessments, although there no standard cut-off for...
Abstract Background The 21-gene recurrence score (RS) predicts the benefit of adjuvant chemotherapy (CT) in ER-positive HER2-negative breast cancer (BC) and has been validated population where women under 40 are underrepresented.Young BC pts more likely to receive addition endocrine therapy (ET). Our objective was assess RS results young (≤40 yo) vs older (>40 evaluate impact age on clinical decision-making according categories. Methods We retrospectively reviewed electronic medical...
Abstract Background: The gene expression profiling assay OncotypeDx (ODx) prognosticates the risk of estrogen receptor positive (ER+) breast cancer (BC) recurrence and assesses likely benefit from adjuvant chemotherapy in addition to endocrine therapy. Numerous clinical utility studies have shown that acknowledging RS impacts on decision making, leading a decrease (CT) use. However, cost limits it widespread use, especially low middle-income countries. Our objective was determine patterns...
e15068 Background: The incidence of colorectal cancer (CRC) in Peru has increased the last decades. Approximately 20% patients with CRC already have metastases at diagnosis, and this figure been stable over two lack data makes it more difficult to manage our patients. metastatic setting second primary malignancies are complicated scenarios. objective study was explore describe metastasis patterns malignancies’ frequency Methods: We retrospectively reviewed electronic medical records 609 from...
e15095 Background: The incidence of colorectal cancer (CRC) in Peru has increased the last decades. In our country, toxicities systemic treatment have not been analyzed a large population different disease settings. Numerous clinical studies shown an association between and age, type chemotherapy, number courses, others. Our objective was to explore presented find if any variables could help us predict these toxicities. Methods: We retrospectively reviewed electronic medical records 371...
e15111 Background: The incidence of colorectal cancer (CRC) in Peru has increased the last decades. Needing to use all possible tools for an accurate diagnosis and early treatment. Neutrophil-to-lymphocyte ratio (NLR) been associated as poor prognostic factor OS PFS CRC. There is no data that support this statement Latin America. It a special utility our country detection simple reproducible biomarker guides more advanced tests. Our objective was explore factors with local-locally metastatic...