A5110511388- Ruminant Nutrition and Digestive Physiology
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Genetic and phenotypic traits in livestock
- Reproductive Physiology in Livestock
- Metabolomics and Mass Spectrometry Studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Lipids, and Metabolism
- Advanced Proteomics Techniques and Applications
- Cancer Genomics and Diagnostics
- Monoclonal and Polyclonal Antibodies Research
- Radiopharmaceutical Chemistry and Applications
- Gut microbiota and health
- Ferroptosis and cancer prognosis
- Nanoparticle-Based Drug Delivery
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- Glycosylation and Glycoproteins Research
- Bladder and Urothelial Cancer Treatments
- Antimicrobial Peptides and Activities
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Enzyme function and inhibition
- Alcohol Consumption and Health Effects
China National Pharmaceutical Group Corporation (China)
2024
Chinese Academy of Agricultural Sciences
2020-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2022
Shandong Provincial Hospital
2021
Shandong First Medical University
2021
Abstract Currently, imaging, fecal immunochemical tests (FITs) and serum carcinoembryonic antigen (CEA) are not adequate for the early detection evaluation of metastasis recurrence in colorectal cancer (CRC). To comprehensively identify validate more accurate noninvasive biomarkers urine, we implement a staged discovery-verification-validation pipeline 657 urine 993 tissue samples from healthy controls CRC patients with distinct metastatic risk. The generated diagnostic signature combined...
Papillary thyroid carcinoma (PTC) accounts for the majority of cancer and affects a large number individuals. The pathogenesis PTC has not been completely elucidated thus far. Metabolic reprogramming is common feature in tumours. Our previous research revealed lipid metabolism PTC. Further studies on may help elucidate PTC.Clinical samples para-tumour tissue were analysed using lipidomic, proteomic, metabolomic approaches. A multi-omics integrative strategy was adopted to identify important...
3-Nitrooxypropanol (3-NOP) is effective at reducing ruminal methane emissions in ruminants. But it also causes a drastic increase hydrogen accumulation, resulting feed energy waste. Fumarate key precursor for propionate formation and plays an important role rumen metabolism. Therefore, this study examined the effects of 3-NOP combined with fumarate on volatile fatty acids, methanogenesis, microbial community structures dairy cows
Extracellular vesicles (EVs) are membranous found in biological fluids with essential functions. However, milk-derived EV proteins from clinical mastitis (CM) and subclinical (SM) cows have yet to be studied detail. In this study, EVs of CM, SM, Healthy were extracted using a combination acetic acid/ultracentrifugation density gradient ultracentrifugation analyzed shotgun proteomic by data-independent acquisition mode. A total 1253 milk exosome identified quantified. Differently enriched...
The compound 3-nitrooxypropanol (3-NOP) is a promising methane inhibitor, which performs well in inhibiting emission and does not affect animal feed intake digestibility. However, it causes significant increase hydrogen production while suppressing emission, resulting waste of energy. Vitamin B12 key factor the propionate pathway thus plays an important role regulating utilization pathway. In this study, effects 3-NOP combined with vitamin supplementation on rumen fermentation microbial...
Mastitis is a common and widespread infectious disease in dairy farms around the world, resulting reduced milk production quality. Staphylococcus aureus one of main pathogenic bacteria causing subclinical mastitis cows. S. can activate inflammatory signaling pathways bovine mammary epithelial cells. Exosomes produced by cells directly transfer pathogen-related molecules from cell to cell, thus affecting process infection. Protein material basis immune defense function body; therefore,...
Early lactation dairy cows are vulnerable to negative energy balance (NEB) due reduced dry matter intake (DMI) and high requirements for lactation. This study mainly revealed the mechanism of different doses rumen-protected glucose (RPG) alleviate NEB early lactating through serum untargeted metabolomics, explored effects RPG on rumen fermentation, performance, biochemical indices associated with NEB. Thirty-two multiparous Holstein in lactation, blocked by parity, liveweight, milk yield,...
Negative energy balance (NEB) is the pathological basis of metabolic disorders in early lactation dairy cows. Rumen-protected glucose (RPG) a feed additive to relieve NEB cows lactation. The aims current study were evaluate impact different doses RPG supply on fecal microbiota and metabolome cows, their correlation with each other. A total 24 multiparous Holstein randomly assigned one four treatments for first 35 days period, as follows: control group, basal diet without (CON); low RPG, plus...
Background: Papillary thyroid carcinoma (PTC) accounts for the majority of cancer and affects a large number individuals. The pathogenesis PTC has not been completely elucidated thus far. Metabolic reprogramming is common feature in tumours. Our previous research revealed lipid metabolism PTC. Further studies on may help elucidate PTC.Methods: Clinical samples para-tumour tissue were analysed using lipidomic, proteomic, metabolomic approaches. A multi-omics integrative strategy was adopted...
Abstract Colorectal cancer (CRC) is the third leading prevalent cause of death from in adults, and more than one CRC patients are accompanied by liver metastasis. The disease begins as a benign adenomatous polyp, it subsequently develops into an advanced adenoma gradually progresses to invasive cancer. driving factors behind comprise series successive accumulated gene mutations that follow order “APC-KRAS-TP53-DCC”. Moreover, urine important display window for tumor-derived exosomes. Here,...
Abstract Currently, imaging and serum carcinoembryonic antigen (CEA) tests are not sufficient for early detection evaluation of metastasis recurrence in colorectal cancer (CRC). To comprehensively discover validate more accurate noninvasive biomarkers urine, we adopted a staged discovery-verification-validation pipeline 657 urine 665 tissue samples from healthy controls CRC patients with distinct metastatic risk. The diagnostic signature generated combined CEA levels revealed significantly...