A5100680621- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Medical Imaging Techniques and Applications
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Surgical Treatments
- Liver Disease Diagnosis and Treatment
- Lung Cancer Research Studies
- MRI in cancer diagnosis
- Nerve Injury and Rehabilitation
- Liver Disease and Transplantation
- Colorectal Cancer Treatments and Studies
- Corneal Surgery and Treatments
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Inflammatory Biomarkers in Disease Prognosis
- IL-33, ST2, and ILC Pathways
- Ocular Infections and Treatments
Shandong First Medical University
2009-2025
Shandong Tumor Hospital
2009-2023
Shandong University
2016-2019
Fujian Medical University
2019
Union Hospital
2019
Sixth Affiliated Hospital of Sun Yat-sen University
2018
Sun Yat-sen University
2018
Artificial corneal (AC) implants offer hope to millions with blindness, including 5 million in China. Titanium is one of the materials commonly used fabrication artificial scaffolders because its light texture, high mechanical properties, and biosafety. However, postoperative bacterial infections, especially from Pseudomonas aeruginosa Staphylococcus aureus (S. aureus), remain a significant challenge due bioinert nature titanium materials, leading infection rates. In this study, we introduce...
The analysis was designed to compare dosimetric parameters among 3-D conformal radiotherapy (3DCRT), intensity-modulated (IMRT) and RapidArc (RA) identify which can achieve the lowest risk of radiation-induced liver disease (RILD) for hepatocellular carcinoma (HCC).Twenty patients with HCC were enrolled in this study. Dosimetric values 3DCRT, IMRT, RA calculated total dose 50 Gy/25 f. percentage normal volume receiving >40, >30, >20, >10, >5 Gy (V(40), V(30), V(20), V(10) V(5)) evaluated...
Cytokine interleukin-9 (IL9) plays an essential role in the pathogenesis of inflammatory bowel disease. However, molecular mechanism underlying IL9 pathway remains unknown. Here, we initiate a series studies to characterize components this pathway.The expression colon biopsies from Crohn's disease (CD) and controls were examined by quantitative polymerase chain reaction, immunoblot, immunohistochemistry. The trinitrobenzene sulfonic acid (TNBS)-induced colitis model was used verify...
The aim of this study was to determine whether pretreatment status human epidermal growth factor receptor-2 (HER-2) could predict pathologic response neoadjuvant chemoradiotherapy (nCRT) and outcomes for patients with locally advanced rectal cancer (LARC). A total 119 diagnosed LARC received standardized multimodal treatment. Their HER-2 determined in biopsies by immunohistochemistry (IHC) FISH. Tumor assessed resected regimens using the tumor regression grade system TNM staging system....
Background: Peripheral blood lymphocytes play an important role in antitumour immunity. We examined the relationship between minimum absolute lymphocyte counts (Min ALCs) during radiotherapy (RT) and clinical outcomes patients with hepatocellular carcinoma (HCC). Methods: Data from a total of 69 HCC who had received RT were retrospectively analysed. measured before RT, weekly after RT. Regression mixed-effect models used to assess relationships potential predictors overall survival (OS)....
Numerous studies have tried to combine transarterial chemoembolization (TACE) or hepatic arterial infusion chemotherapy (HAIC) with radiotherapy (RT) for the treatment of hepatocellular carcinoma (HCC) patients portal vein tumor thrombus (PVTT). However, efficacy TACE HAIC combined RT versus alone remains controversial. Thus, we performed a meta-analysis compare and safety intra-arterial HCC PVTT.PubMed, Embase, Cochrane Library databases were systematically searched eligible studies. Two...
Neoadjuvant chemoradiotherapy (nCRT) combined with surgery has been implemented as a standard treatment strategy in locally advanced rectal cancer (LARC). However, there is wide spectrum of response to nCRT. The aim this study was determine whether enhancer zeste homologue 2 (EZH2 ) expression could predict nCRT and outcomes for patients LARC.The examined the EZH2 112 biopsies by immohistochemistry. associations between clinical characters were analyzed.EZH2 biopsy tissue significantly...
Spinal cord injury is a serious disabling condition. Transplantation of olfactory ensheathing cells (OECs) one the most promising treatments for spinal (SCI). Thirty-nine patients with chronic SCI received OEC transplantation and completed long-term follow-up, minimum follow-up 7 years. We assessed sensorimotor function American Injury Association (ASIA) Impairment Scale (AIS) autonomic nervous by International Standards to document remaining Autonomic Function after Cord (ISAFSCI),...
The detection of γ-glutamyl transferase (GGT) has previously been reported to be useful in the diagnosis hepatocellular carcinoma (HCC). aim present study was investigate baseline serum GGT levels patients with intermediate HCC (Barcelona Clinic Liver Cancer stage B) following treatment transcatheter arterial chemoembolization (TACE) combined three-dimensional conformal radiotherapy (3DCRT). A total 154 Child-Pugh grade were retrospectively investigated. Receiver operating characteristic...
Abstract Background Bile duct obstruction is a common issue for patients with advanced cholangiocarcinoma (CCA). Percutaneous transhepatic cholangial drainage (PTCD) often required to relieve the obstruction. However, PTCD may alter intestinal microbiota, which can affect efficacy of immunotherapy. Antibiotics (ATB) also have significant immunomodulatory effects by perturbing gut microbiota. Therefore, this study aimed investigate whether or ATB therapy associated overall survival (OS)...
Abstract microRNA‐3607 (miR‐3607) has been identified as an important biomarker, and its aberrant expression exerts a significant role in tumorigenesis. However, the biological function of miR‐3607 hepatocellular carcinoma (HCC) needs to be deciphered comprehensively. Clinical samples HCC patients, well normal cases, were derived from The Cancer Genome Atlas database. Quantitative reverse transcription polymerase chain reaction (qRT‐PCR) Western blotting analyses utilized detect levels...
The aim of this study, was to investigate the relationship between 18F‑fluorodeoxyglucose (18F‑FDG) uptake in primary tumors and clinicopathological characteristics esophageal squamous cell carcinoma (ESCC) patients. Patients with histopathologically diagnosed ESCC who had received a pre‑therapeutic 18F‑FDG positron emission tomography‑computed tomography (PET‑CT) scan were enrolled study. maximum standardized value (SUVmax) length tumor measured by PET‑CT. clinical tumor‑node‑metastasis...
To analyze alterations of the liver appearance during hepatobiliary phase individuals with type 2 diabetes who are receiving gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) enhanced magnetic resonance imaging (MRI). Fifty-seven received Gd-EOB-DTPA-enhanced MRI and had normal renal function but did not have (control group) or (observation were retrospectively included in this study. The enhancement ratio (LER) contrast between parenchyma portal vein (LPC) calculated...
Abstract Objective The aim of this study was to the quantitative expression circulating tumour DNA (ctDNA) in patients with non-small cell lung cancer (NSCLC) before and after radical operation explore correlation between gene mutations tissues those ctDNA. Methods We randomly assigned 5 NSCLC from Department Thoracic Surgery Fujian Medical University Union Hospital. All had undergone surgery. Venous blood samples were collected at two time points (before 21-37 days operation) for monitoring...