A5068783389- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Pulmonary Hypertension Research and Treatments
- Knee injuries and reconstruction techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Osteoarthritis Treatment and Mechanisms
- Nanoparticle-Based Drug Delivery
- Innovative Microfluidic and Catalytic Techniques Innovation
- Nanocluster Synthesis and Applications
- Advanced Sensor and Energy Harvesting Materials
- Hydrogels: synthesis, properties, applications
- Reproductive Biology and Fertility
- Ion-surface interactions and analysis
- Medical Research and Treatments
- Additive Manufacturing and 3D Printing Technologies
University of Michigan
2021-2023
University of Oklahoma
2019-2021
Synthetic matrices which mimic the extracellular composition of native tissue create a comprehensive model for studying development and disease. Here, we have engineered composite material retains cell-secreted ECM culture ovarian follicles by embedding electrospun dextran fibers functionalized with basement membrane binder (BMB) peptide in PEG hydrogels. In presence ECM-sequestering fibers, encapsulated immature primordial stromal cells aggregated into large organoid-like structures dense...
Nanoparticle cellular interactions are governed by nanoparticle surface chemistry and the display of functional (bio)molecules. To conjugate thiol-containing (bio)molecules on surfaces, reactions between thiols maleimide groups often exploited. However, current procedures for modifying surfaces with complex can result in aggregation. Here, we demonstrate a straightforward, fast (∼30 min), efficient, robust one-step engineering protocol gold nanoparticles groups. We designed...
There is growing evidence indicating the need to combine rehabilitation and regenerative medicine fields maximize functional recovery after spinal cord injury (SCI), but there are limited methods synergistically fields. Conductive biomaterials may enable synergistic combination of with electric stimulation (ES), which direct ES neurons enhance axon regeneration reorganization for better recovery; however, three major challenges in developing conductive biomaterials: (1) low conductivity...
Pulmonary arterial hypertension (PAH) is a progressive disease of the lung vasculature, characterized by elevated pulmonary blood pressure, remodeling arteries, and ultimately right ventricular failure. Therapeutic interventions for PAH are limited in part lack ofin vitroscreening platforms that accurately reproduce dynamic wall mechanical properties. Here we present 3D-bioprinted model adventitia comprised phototunable poly(ethylene glycol) alpha methacrylate (PEG-αMA)-based hydrogel...
The potential chondroinductivity from cartilage matrix makes it promising for repair; however, matrix-based hydrogels developed thus far have failed to match the mechanical performance of native or be bioprinted without adding polymers reinforcement. There is a need with robust and paste-like precursor rheology bioprinting/enhanced surgical placement. In current study, our goals were increase hydrogel stiffness develop precursor/printability methacryl-modified solubilized devitalized...
Abstract Pulmonary arterial hypertension (PAH) is a progressive disease of the lung vasculature, characterized by elevated pulmonary blood pressure, remodeling arteries, and ultimately right ventricular failure. Therapeutic interventions for PAH are limited in part lack vitro screening platforms that accurately reproduce dynamic wall mechanical properties. Here we present 3D-bioprinted model adventitia comprised phototunable poly(ethylene glycol) alpha methacrylate (PEG-αMA)-based hydrogel...
3D bioprinting technologies are rapidly developing and provide a platform for manufacturing structures that mimic the in vivo environment.Recent research aims to produce bioprinted recapitulate both structure functionality.Advancements producing high fidelity functional pave way full organ bioprinting.Full holds promise patients facing renal diseases given limited availability of donor kidneys transplantation which offers highest quality life failure.While generation fully kidney is...