A5000622434- Nerve injury and regeneration
- Spinal Cord Injury Research
- Nerve Injury and Rehabilitation
- RNA Interference and Gene Delivery
- Peripheral Nerve Disorders
- Neurogenesis and neuroplasticity mechanisms
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Cerebral Palsy and Movement Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Wound Healing and Treatments
- Signaling Pathways in Disease
- Hemostasis and retained surgical items
- Blood Coagulation and Thrombosis Mechanisms
- Immune Response and Inflammation
- Surgical Sutures and Adhesives
- Cardiovascular Issues in Pregnancy
- Botulinum Toxin and Related Neurological Disorders
- Reconstructive Surgery and Microvascular Techniques
- Cardiac Structural Anomalies and Repair
- Traumatic Brain Injury Research
- Spinal Dysraphism and Malformations
- Tissue Engineering and Regenerative Medicine
- Orthopedic Surgery and Rehabilitation
- Musculoskeletal pain and rehabilitation
University of Wisconsin–Madison
2016-2025
Neurological Surgery
2013-2024
Creative Commons
2023
Hillenbrand (United States)
2018
The anti-inflammatory cytokine interleukin-10 (IL-10) has been explored previously as a treatment method for spinal cord injury (SCI) due to its ability attenuate pro-inflammatory cytokines and reduce apoptosis. Primary limitations when using systemic injections of IL-10 are that it is rapidly cleared from the site does not cross blood-spinal barrier.Here, mineral-coated microparticles (MCMs) were used obtain local sustained delivery directly into after SCI.Female Sprague-Dawley rats...
Abstract JOURNAL/nrgr/04.03/01300535-202406000-00035/inline-graphic1/v/2023-10-30T152229Z/r/image-tiff After spinal cord injury, there is an extensive infiltration of immune cells, which exacerbates the injury and leads to further neural degeneration. Therefore, a major aim current research involves targeting response as treatment for injury. Although much has been performed analyzing complex inflammatory process following remain discrepancies within previous literature regarding timeline...
Spinal cord injury often results in devastating consequences for those afflicted, with very few therapeutic options. A central element of spinal injuries is astrogliosis, which forms a glial scar that inhibits neuronal regeneration post-injury. Chondroitinase ABC (ChABC) an enzyme capable degrading chondroitin sulfate proteoglycan (CSPG), the predominant extracellular matrix component scar. However, poor protein stability remains challenge its use. Messenger RNA (mRNA) delivery emerging gene...
Because of the dynamics spinal cord injury (SCI), optimal treatment will almost certainly be a combination approach to control environment and promote axonal growth. This study uses peripheral nerve grafts (PNGs) as scaffolds for growth while delivering neurotrophin‐3 (NT‐3) via calcium phosphate (CaP) coatings on surgical sutures. CaP coating was grown sutures, NT‐3 binding release were characterized in vitro. Then, NT‐3‐loaded sutures tested complete SCI model. Rats analyzed functional...
The regeneration of axons after a spinal cord injury or disease is attracting significant amount interest among researchers. Being able to assess these in terms morphology, length and origin essential our understanding the process. Recently, two specific axon tracers have gained much recognition; biotinylated dextran amine (BDA) 10 kDa as an anterograde tracer cholera toxin-B retrograde tracer. However, there are still several complexities when using tracers, including volume that should be...
Spinal cord injury (SCI) is a devastating trauma that currently affects 54 people out of every million, which approximately 270,000 in the United States (National Cord Injury Statistical Center, 2013). The effects such an can cause loss both motor and sensory function below site, normally leaving patient unable to care for themselves entirely relying on family friends provide personal care. Currently there are no definitive cures SCI; however, several potential treatments being researched....
For nerve injuries, not amendable to tensionless epineural coaptation of the nerve, autografts are preferred treatment. Although absorbable sutures recommended for repair, there is no evidence that non-absorbable superior sutures. This study aims assess effectiveness monofilament nylon sutures, vicryl and fibrin glue when used grafting.
The gold standard for treating peripheral nerve injuries that have large gaps where the nerves cannot be directly sutured back together because it creates tension on nerve, is to incorporate an autologous graft. However, even with incorporation of a graft, generally patients only regain small portion function in limbs affected by injury. Although, there has been some promising results using growth factors induce more axon through many these previous therapies are limited their ability...
Abstract Brachial plexus injury (BPI) occurs when the brachial is compressed, stretched, or avulsed. Although rodents are commonly used to study BPI, these models poorly mimic human BPI due discrepancy in size. The objective of this was compare between and Wisconsin Miniature Swine TM (WMS ), which approximately weight an average (68–91 kg), determine if swine would be a suitable model for studying mechanisms treatments. To analyze gross anatomy, WMS plexuses were dissected both anteriorly...
Objective: Autologous peripheral nerve grafts are commonly used clinically as a treatment for injuries. However, in research using an autologous graft is not always feasible due to loss of function, which many cases assessed determine the efficacy graft. In addition, allografts require use immunosuppressant, creates unwanted side effects and another variable within experiment that can affect regeneration. The objective this study was analyze rejection cyclosporine A (CSA) on axonal...
Spinal cord injury (SCI) is a devastating trauma that leaves approximately 10,000 to 20,000 people paralyzed every year in the United States. The majority of these cases are young will live almost full life expectancy, however, their quality significantly reduced. After SCI there loss both sensory and motor function below level injury. Due this patients often unable care for themselves rely on friends family serve as primary caregivers. Christopher Reeve Foundation found more than 50 million...
Background: Peripheral nerve grafts (PNGs) in the spinal cord support axonal regeneration and functional recovery. Chondroitinase ABC (ChABC) has been used to break down chondroitin sulfate proteoglycans (CSPGs) that inhibit regeneration. If ChABC is effectively delivered injury site, CSPGs can be broken so axons pass through distal interface between graft before CSPG accumulation an adverse impact on recovery. Methods: In this study, we tested synergistic effect of using predegenerated...
Abstract Background: Brachial plexus injury (BPI) occurs when the brachial is compressed, stretched, or avulsed. Although rodents are commonly used to study BPI, these models poorly mimic human BPI due discrepancy in size. The objective of this was compare between and Wisconsin Miniature Swine TM (WMS ), which approximately weight an average (68–91 kg), determine if swine would be a suitable model for studying mechanisms treatments. Methods: To analyze gross anatomy, WMS plexi were dissected...
INTRODUCTION: Currently, there are no treatments to help regain a significant amount of the function that is lost after spinal cord injury (SCI). A primary reason for lack in functional recovery glial scar, which forms SCI and inhibits axonal regeneration. Chondroitinase ABC (ChABC), bacterial enzyme, digests one main inhibitors chondroitin sulfate proteoglycans (CSPGs), results regeneration recovery. However, ChABC not thermally stable quickly becomes inactive at body temperature. Recently,...