Meredith G. Wesley
A5002854993- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Respiratory viral infections research
- Vaccine Coverage and Hesitancy
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- Animal Disease Management and Epidemiology
- Retinal and Optic Conditions
- Infection Control and Ventilation
- Transgenic Plants and Applications
- Nerve Injury and Rehabilitation
- Hepatitis C virus research
- COVID-19 and healthcare impacts
- Mobile Crowdsensing and Crowdsourcing
- Maternal and Perinatal Health Interventions
- Viral Infections and Outbreaks Research
- Nerve injury and regeneration
- Smoking Behavior and Cessation
- Child and Adolescent Health
- Travel-related health issues
- Global Maternal and Child Health
- Wound Healing and Treatments
Abt Global (United States)
2020-2024
Centers for Disease Control and Prevention
2019-2024
Schulman, Ronca & Bucuvalas
2020-2023
University of Arizona
2023
Marshfield Clinic
2023
University of Utah
2023
Saint Luke's Health System
2021
Regional Health
2021
Abt Associates (Nepal)
2021
University of Wisconsin–Madison
2016
Messenger RNA (mRNA) BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) COVID-19 vaccines have been shown to be effective in preventing symptomatic randomized placebo-controlled Phase III trials (1,2); however, the benefits of these for asymptomatic SARS-CoV-2 (the virus that causes COVID-19) infection, particularly when administered real-world conditions, is less well understood. Using prospective cohorts health care personnel, first responders, other essential frontline workers* eight U.S....
Information is limited regarding the effectiveness of two-dose messenger RNA (mRNA) vaccines BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) in preventing infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attenuating disease 2019 (Covid-19) when administered real-world conditions.
Abstract Repeat vaccination with egg-based influenza vaccines could preferentially boost antibodies targeting the egg-adapted epitopes and reduce immunogenicity to circulating viruses. In this randomized trial (Clinicaltrials.gov: NCT03722589), sera pre- post-vaccination quadrivalent inactivated (IIV4), cell culture-based (ccIIV4), recombinant (RIV4) were collected from healthcare personnel (18-64 years) in 2018−19 ( N = 723) 2019−20 684) seasons. We performed an exploratory analysis....
In a cohort of essential workers in the United States previously infected with SARS-CoV-2, risk factors for reinfection included being unvaccinated, infrequent mask use, time since first infection, and non-Hispanic Black. Protecting from requires multipronged approach including up-to-date vaccination, use as recommended, reduction underlying health disparities.
Abstract Background RIV4 and cell-culture based inactivated influenza vaccine (ccIIV4) have not been compared to egg-based IIV4 in healthcare personnel, a population with frequent vaccination that may blunt immune responses over time. We conducted randomized trial among personnel (HCP) aged 18–64 years compare humoral ccIIV4 IIV4. Methods During the 2018–2019 season, participants were receive ccIIV4, RIV4, or had serum samples collected prevaccination, 1 6 months postvaccination. Serum...
Workers critical to emergency response and continuity of essential services during the COVID-19 pandemic are at a disproportionally high risk SARS-CoV-2 infection. Prospective cohort studies needed for enhancing understanding incidence symptomatic asymptomatic infections, identifying factors, assessing clinical outcomes, determining effectiveness vaccination.The Research on Epidemiology in Essential Response Personnel (RECOVER) prospective study was designed estimate examine factors...
Emerging data suggest that second-generation influenza vaccines with higher hemagglutinin (HA) antigen content and/or different production methods may induce stronger antibody responses to HA than standard-dose egg-based in adults. We compared high-dose inactivated (HD-IIV3), recombinant (RIV4), and cell culture-based (ccIIV4) vs vaccine (SD-IIV4) among health care personnel (HCP) aged 18-65 years 2 seasons (2018-2019, 2019-2020).
Because of the dynamics spinal cord injury (SCI), optimal treatment will almost certainly be a combination approach to control environment and promote axonal growth. This study uses peripheral nerve grafts (PNGs) as scaffolds for growth while delivering neurotrophin‐3 (NT‐3) via calcium phosphate (CaP) coatings on surgical sutures. CaP coating was grown sutures, NT‐3 binding release were characterized in vitro. Then, NT‐3‐loaded sutures tested complete SCI model. Rats analyzed functional...
Abstract Background Healthcare personnel (HCP) are a priority group for annual influenza vaccination. Few studies have assessed the validity of recall prior vaccination status among HCP, especially more than one preceding season. Methods Using data from randomized controlled trial 947 HCP two US healthcare systems, we agreement between participant self‐report and administrative record documentation during five seasons; kappa coefficients sensitivity values were calculated. Administrative was...
Introduction: We evaluated knowledge, attitudes, and practices (KAP) related to influenza vaccination among pregnant women in three selected countries.Methods: During 2017, seeking antenatal care at hospitals participating sites were enrolled. described characteristics responses KAP questions. also predictors associated with during pregnancy substantial vaccine uptake by multivariable logistic regression.Results: Overall, 4,648 completed the survey. There differences survey populations; only...
ABSTRACT BACKGROUND Information is limited on messenger RNA (mRNA) BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) COVID-19 vaccine effectiveness (VE) in preventing SARS-CoV-2 infection or attenuating disease when administered real-world conditions. METHODS Prospective cohorts of 3,975 healthcare personnel, first responders, other essential frontline workers completed weekly testing during December 14 2020—April 10 2021. Self-collected mid-turbinate nasal swabs were tested by qualitative...
Data on the development of neutralizing antibodies (nAbs) against SARS-CoV-2 after infection and vaccination with mRNA COVID-19 vaccines are limited.From a prospective cohort 3975 adult essential frontline workers tested weekly from August 2020 to March 2021 for by reverse transcription-polymerase chain reaction assay irrespective symptoms, 497 participants had sera drawn (170), (327), both (50 population). Serum was collected each vaccine dose. Serum-neutralizing antibody titers...
Abstract Background We sought to evaluate the impact of changes in estimates COVID‐19 vaccine effectiveness on incidence laboratory‐confirmed infection among frontline workers at high risk for SARS‐CoV‐2. Methods analyzed data from a prospective worker cohort estimate by month as well association vaccination, occupation, demographics, physical distancing, and mask use with risk. Participants completed baseline quarterly surveys, each week self‐collected mid‐turbinate nasal swabs reported...
Abstract Background Antibody responses to non–egg-based standard-dose cell-culture influenza vaccine (containing 15 µg hemagglutinin [HA]/component) and recombinant 45 HA/component) during consecutive seasons have not been studied in the United States. Methods In a randomized trial of immunogenicity quadrivalent vaccines among healthcare personnel (HCP) aged 18–64 years over 2 seasons, HCP who received recombinant-HA (RIV) or cell culture–based inactivated (ccIIV) first season (year 1) were...
Cesarean delivery rates have increased globally resulting in a public health concern. We estimate of cesarean deliveries among Thai women using the World Health Organization (WHO) Robson Classification system and compare by group to guideline for acceptable identify groups that might benefit most from interventions rate reduction.
Assessing the real-world effectiveness of COVID-19 vaccines and understanding incidence severity SARS-CoV-2 illness in children are essential to inform policy guide health care professionals advising parents caregivers who test positive for SARS-CoV-2.This report describes objectives methods conducting Pediatric Research Observing Trends Exposures Timelines (PROTECT) study. PROTECT is a longitudinal prospective pediatric cohort study designed estimate vaccine (VE) against infection among...
Abstract Background Data on antibody kinetics are limited among individuals previously infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). From a cohort of healthcare personnel and other frontline workers in 6 US states, we assessed waning after messenger RNA (mRNA) dose response to 3 according SARS-CoV-2 infection history. Methods Participants submitted sera every months, infection, each mRNA vaccine dose. Sera were tested for antibodies reported as area under the...
The Estudio Vacuna de Influenza Peru (VIP) cohort aims to describe the frequency of influenza virus infection, identify predictors vaccine acceptance, examine effects repeated vaccination on immunogenicity, and evaluate effectiveness among HCP.The VIP prospectively followed HCP in Lima, Peru, during 2016-2018 seasons; a fourth year is ongoing. Participants contribute blood samples before after season (for vaccinees). Weekly surveillance conducted acute respiratory or febrile illnesses...
While there is evidence that COVID-19 vaccination protects against development of post-COVID conditions (PCC) after severe infection data are limited on whether reduces the risk cases less-severe non-hospitalized disease with more recent SARS-CoV-2 variant viruses. This study assessed was protective subsequent PCC in persons predominantly mild initial infections during both Delta and Omicron predominance.
Few studies have examined influenza vaccine effectiveness (VE) among women during pregnancy in middle-income countries. We used data from a prospective cohort of who were pregnant Peru to estimate the 2018 Southern Hemisphere vaccine. Women at <28 weeks gestation enrolled 4 tertiary level hospitals Lima, start season and followed until end their pregnancies. Participants had mid-turbinate nasal swabs collected tested for by reverse-transcription polymerase chain reaction (RT-PCR) with onset...
The World Health Organization (WHO) recommends case definitions for influenza surveillance that are also used in public health research, although their performance has not been assessed many risk groups, including pregnant women whom may manifest differently. We evaluated the of symptom-based to detect a cohort India, Peru, and Thailand.
ABSTRACT Background Data on the development of neutralizing antibodies against SARS-CoV-2 after infection and vaccination with messenger RNA (mRNA) COVID-19 vaccines are limited. Methods From a prospective cohort 3,975 adult essential frontline workers tested weekly from August, 2020 to March, 2021 for by Reverse Transcription- Polymerase Chain Reaction (RT-PCR) assay irrespective symptoms, 497 participants had sera drawn (170), (327), both (50 population). Serum was collected each vaccine...