A5012122628- Genetic Associations and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Healthcare Policy and Management
- GDF15 and Related Biomarkers
- Nutritional Studies and Diet
- Tryptophan and brain disorders
- Obesity, Physical Activity, Diet
- SARS-CoV-2 detection and testing
- Long-Term Effects of COVID-19
- Genetic Mapping and Diversity in Plants and Animals
- Bioinformatics and Genomic Networks
- Diet and metabolism studies
- COVID-19 Clinical Research Studies
- Infection Control and Ventilation
- Liver Disease Diagnosis and Treatment
- Respiratory and Cough-Related Research
- Viral gastroenteritis research and epidemiology
University of Arizona
2022-2025
Importance Data on the epidemiology of mild to moderately severe COVID-19 are needed inform public health guidance. Objective To evaluate associations between 2 or 3 doses mRNA vaccine and attenuation symptoms viral RNA load across SARS-CoV-2 lineages. Design, Setting, Participants A prospective cohort study essential frontline workers in Arizona, Florida, Minnesota, Oregon, Texas, Utah with infection confirmed by reverse transcriptase–polymerase chain reaction testing lineage classified...
Physical activity (PA), including sedentary behavior, is associated with many diseases, Alzheimer's disease and all-cause dementia. However, the specific biological mechanisms through which PA protects against are not entirely understood. To address this knowledge gap, we first assessed conventional observational associations of three self-reported device-based measures circulating levels 2,911 plasma proteins measured in UK Biobank (n max =39,160) functional enrichment identified proteins....
Introduction Postacute sequelae of SARS-CoV-2 infection (PASC) are extensive. Also known as long COVID, primary outcomes reported neurologic, cardiac and respiratory in nature. However, several studies have also an increase gastrointestinal (GI) symptoms syndromes following COVID-19. This study PASC will include extensive analyses GI symptoms, determine if people with pre-existing irritable bowel syndrome (IBS) at higher risk developing generally or PASC-GI, which biomarkers impacted to what...
Background: Late-onset Alzheimer’s disease (LOAD) represents a growing health burden. Previous studies suggest that blood metabolite levels influence risk of LOAD. Objective: We used genetics-based study design which may overcome limitations other epidemiological to assess the on LOAD risk. Methods: applied Mendelian randomization (MR) evaluate bi-directional causal effects using summary statistics from largest genome-wide association (GWAS) 249 metabolites ( n = 115,082) and GWAS (n case...
Abstract Background Data on antibody kinetics are limited among individuals previously infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). From a cohort of healthcare personnel and other frontline workers in 6 US states, we assessed waning after messenger RNA (mRNA) dose response to 3 according SARS-CoV-2 infection history. Methods Participants submitted sera every months, infection, each mRNA vaccine dose. Sera were tested for antibodies reported as area under the...
A lack of physical activity (PA) is one the most pressing health issues today. Our individual propensity for PA influenced by genetic factors. Stated liking different types may help capture additional and informative dimensions behavior genetics.In over 157,000 individuals from UK Biobank, we performed genome-wide association studies five items assessing types, plus an derived trait overall PA-liking. We attempted to replicate significant associations in Netherlands Twin Register (NTR)...
Background: Various monetary incentive strategies have been used to increase participant adherence in research. Our study examined the impact of two lottery amounts on adherence.Aims/objectives: The objective this paper was quantify a $50 and $100 weekly activities among AZ HEROES participants.Methods: prospective cohort examining COVID-19 infections Arizona frontline workers. Participants submitted nasal swabs detect completed surveys. To adherence, implemented with random winners selected...
Background: Various monetary incentive strategies have been used to increase participant adherence in research. Our study examined the impact of two lottery amounts on adherence.Aims/objectives: The objective this paper was quantify a $50 and $100 weekly activities among AZ HEROES participants.Methods: prospective cohort examining COVID-19 infections Arizona frontline workers. Participants submitted nasal swabs detect completed surveys. To adherence, implemented with random winners selected...