A5029476300- Muscle metabolism and nutrition
- Genetics and Physical Performance
- Cardiovascular and exercise physiology
- Adipose Tissue and Metabolism
- Muscle Physiology and Disorders
- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Exercise and Physiological Responses
- Sports Performance and Training
- Diet and metabolism studies
- Inflammatory mediators and NSAID effects
- Urban Transport and Accessibility
- 3D Printing in Biomedical Research
- Laser Applications in Dentistry and Medicine
- Physical Activity and Health
- Obesity, Physical Activity, Diet
- Mesenchymal stem cell research
- Medical Imaging and Analysis
- Thermoregulation and physiological responses
- High Altitude and Hypoxia
- Silk-based biomaterials and applications
- Sleep and Wakefulness Research
- Climate Change and Health Impacts
- Pancreatic function and diabetes
- Dental Radiography and Imaging
Konkuk University
2014-2024
Konkuk University Medical Center
2020-2022
Yonsei University
2005
Abstract Adult hippocampal neurogenesis (AHN), the lifelong process of formation new neurons in mammalian brain, plays an important role learning and memory. Exercise is effective enhancer AHN; however, molecular mediators exercise-induced AHN are unknown. Recently, lactate was considered as mediator AHN. Therefore, we hypothesized that exercise with intake could augment This study conducted for 5 weeks 7-week-old ICR male mice performed mild-intensity (just below threshold, 55–60%VO 2max )...
Abstract The perception regarding lactate has changed over the past decades, and some of its physiological roles have gradually been revealed. However, effects exogenous on skeletal muscle synthesis remain unclear. This study aimed to confirm a 5‐week administration post‐exercise synthesis. Thirty‐two Institute Cancer Research mice were randomly assigned non‐trained + placebo, lactate, trained groups. Furthermore, 3 g/kg or an equivalent volume saline was immediately administered after...
We compared the effects of chronic exogenous lactate and exercise training, which influence energy substrate utilization body composition improvements at rest during exercise, investigated availability as a metabolic regulator. The mice were divided into four groups: CON (sedentary + saline), LAC lactate), EXE (exercise EXLA lactate). total experimental period was set 4 weeks, training intensity 60-70% VO2max, each group administered solution immediately after exercise. Changes in protein...
[Purpose] This study investigated the effects of exogenous lactate intake on energy metabolism during 1 h rest after acute exercise.[Methods] Eight-week-old ICR mice were randomly divided into four groups: SED (no treatment), EXE (exercise only), LAC (post-exercise oral administration), and SAL saline administration) (n=8 per group). The exercise intensity was at VO<sub>2</sub>max 80% 25 m/min 15° slope for 50 min. After exercise, groups ingested orally, respectively, allowed to...
Blood glucose and insulin resistance were lower following hypoxic exposure in previous studies. However, the effect of hypoxia as therapy obese model has not been unknown. Six-week-old mice randomly divided into chow diet (n=10) high-fat (HFD) groups (n=20). The group received a non-purified commercial (65 % carbohydrate, 21 protein, 14 fat) water ad libitum. HFD was fed an (Research Diet, #D12492; 60% kcal from fat, 5.24 kcal/g). Both consumed their respective for 7 weeks. Subsequently,...
In this study, we investigated the effects of exogenous lactate administration before exercise on energy substrate utilization during exercise. Mice were divided into control (EX) and with intake (EXLA) groups; saline/lactate was administered 30 min Respiratory gas measured moderate intensity treadmill (30 min). Immediately after exercise, blood, liver, skeletal muscle samples collected mRNA levels metabolism-related metabolic factors analyzed. At 16–30 respiratory exchange ratio (p = 0.045)...
The purpose of the study was to investigate effects 4 weeks lactate intake immediately after endurance exercise on maximal oxygen uptake (VO2max) in performance.Seven-week-old mice from Institute Cancer Research (ICR) were randomly divided into four groups: vehicle (SE/CON), (SE/LAC), with (EX/ CON), and LAC). Mice subjected 60-70% VO2max or without oral 5 days/ week for weeks. measurements (VO2max, time exhaustion (TTE), respiratory exchange rate, fat oxidation, carbohydrate oxidation)...
[Purpose] Public transportation (PT) systems significantly shape urban mobility and have garnered attention owing to their potential impact on public health, particularly the promotion of physical activity. Beyond functions, PT also affect daily energy expenditure through non-exercise activity thermogenesis (NEAT). This mini-review surveys existing literature explore effects use NEAT levels subsequent health outcomes.[Methods] A comprehensive search was conducted using electronic databases...
【To find out the suppressive effect of natural extract Curcuma xanthorrhiza on $IL-1{\beta}$ and MMP-2 derived from periodontal ligament cells through in vitro study to confirm its plaque gingivitis clinical study, containing toothpaste was used following results were produced. 1. In type IV collagenase production inhibited dose-dependently group treated with compared control group. 2. $IL-l{\beta}$ which is one inflammatory mediators associated periodontitis xanthorrhiza. 3. On third week,...
Purpose This study aimed to investigate the effects of acute cold stress (10℃, 0℃) compared with ordinary temperature (20℃) on exercise performance and physiological response at rest during exercise. Methods A total 10 healthy men (21.55 ± 2.16) were selected. In each environmental condition (20℃, 10℃, 0℃), three testing order was randomly selected crossover, there a week interval between graded test (GXT). On day, they remained resting for 30 min in condition. Dependent variables (body...
Purpose In the past, lactate has been considered a by‐product of lack oxygen in skeletal muscle and accumulates muscles blood, which causing acidosis fatigue. However, is always produce, removed or used regardless presence oxygen, it identified as an important metabolite that maintain constancy glucose, ATP (adenosine triphosphate) cells, changing understanding lactate. Nevertheless, effects exogenous intake have not explained there no study interrelationship between ingestion time exercise....
Purpose Lactate had been recognized as fatigue substance during high intensity exercise. However, the lactate paradigm has changed in last decades, and it was reconsidered a potential factors of energy resource muscle adaptation. Nevertheless, effect administration exogenous on not elucidated, no molecular signaling study synthesis over time after ingestion. Therefore, we aimed to investigate skeletal muscle, according different intervals within 2 hours. Methods Male rats were randomly...
Lactate, once considered a "metabolic end-product", is now recognized as an important substrate for energy metabolism pathways reuse source have been revealed. In previous study, it was investigated that the intake of lactate at rest increases activation oxidative phosphorylation factors (pyruvate dehydrogenase, cluster differentiation 36). addition, through respiratory gas, glycogen contents, and glycolysis-related factor (hexokinase 2) before exercise carbohydrate oxidation in during...
Lactate, secreted by skeletal muscle during exercise, had been known as fatigue substance. However, several physiological roles of lactate have revealed in the last decades, and previous studies reported that treatment increased protein synthesis factors muscle. Nevertheless, underlying molecular mechanisms exogenous on degradation remain unknown, there was no study confirm long-term administration with exercise training. Therefore, purpose is to investigate effect training degradation.32...
Abstract Background: The perception regarding lactate has changed over the past decades, with some of its physiological roles having been revealed. However, effects exogenous on skeletal muscle synthesis remain unclear. Therefore, this study aimed to confirm long-term and post-exercise administration synthesis. Methods: 32 ICR mice were randomly assigned non-trained + placebo (Non/Pla), (Non/Lac), tranied (Tr/Pla), or trained (Tr/Lac) groups. Lactate (3 g/kg) same volume saline was...