A5003960285- Trypanosoma species research and implications
- Microtubule and mitosis dynamics
- Genetic and Kidney Cyst Diseases
- Glycosylation and Glycoproteins Research
- Legume Nitrogen Fixing Symbiosis
- Parasite Biology and Host Interactions
- Parasitic Infections and Diagnostics
- Research on Leishmaniasis Studies
- Insect symbiosis and bacterial influences
- Chromosomal and Genetic Variations
- Lysosomal Storage Disorders Research
- Child Nutrition and Water Access
- Parasites and Host Interactions
- Lipid metabolism and biosynthesis
- Pancreatic function and diabetes
Oxford Brookes University
2023-2025
Universidade Federal de Santa Catarina
2023-2024
Cilia and flagella associated protein 410 (CFAP410) is a localized at the basal body of cilia/flagella plays essential roles in ciliogenesis. Multiple single amino acid mutations CFAP410 have been identified patients. However, molecular mechanism for how cause these disorders remains poorly understood due to lack high-resolution structures protein. Our studies demonstrate that adopts bimodular architecture. We previously reported our structural on C-terminal domain (CTD) from various...
Cilia are antenna-like organelles protruding from the surface of many cell types in human body. Defects ciliary structure or function often lead to diseases that collectively called ciliopathies. and flagella-associated protein 410 (CFAP410) localizes at basal body cilia/flagella plays essential roles ciliogenesis, neuronal development DNA damage repair. It remains unknown how its specific location is achieved. Multiple single amino acid mutations CFAP410 have been identified patients with...
Abstract Leishmania are flagellated eukaryotic parasites that cause leishmaniasis and closely related to the other kinetoplastid such as Trypanosoma brucei . In all these there is a cell membrane invagination at base of flagellum called flagellar pocket, which tightly associated with sculpted by cytoskeletal structures including attachment zone (FAZ). The FAZ complex interconnected structure linking body has critical roles in morphogenesis, function pathogenicity. However, this varies...
Abstract Cilia and flagella associated protein 410 (CFAP410) is a localized at the basal body of cilia/flagella plays essential roles in ciliogenesis. Multiple single amino acid mutations CFAP410 have been identified patients. However, molecular mechanism for how cause these disorders remains poorly understood due to lack high-resolution structures protein. Our studies demonstrate that adopts bimodular architecture. We previously reported our structural on C-terminal domain (CTD) from...