A5069937960- Microtubule and mitosis dynamics
- Cellular transport and secretion
- Endoplasmic Reticulum Stress and Disease
- Genetic and Kidney Cyst Diseases
- Fungal and yeast genetics research
- Lipid metabolism and biosynthesis
- Glycosylation and Glycoproteins Research
- 14-3-3 protein interactions
- Chromosomal and Genetic Variations
- Legume Nitrogen Fixing Symbiosis
- Erythrocyte Function and Pathophysiology
- Pancreatic function and diabetes
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Epigenetics and DNA Methylation
- Redox biology and oxidative stress
- Biotin and Related Studies
- RNA regulation and disease
Medical University of Vienna
2018-2025
Max Perutz Labs
2022-2025
Vienna Biocenter
2022-2025
Comprehensive Cancer Center Vienna
2018
Abstract Due to their high biological activity, thiosemicarbazones have been developed for treatment of diverse diseases, including cancer, resulting in multiple clinical trials especially the lead compound Triapine. During last years, a novel subclass anticancer has attracted substantial interest based on enhanced cytotoxic activity. Increasing evidence suggests that double-dimethylated Triapine derivative Me 2 NNMe differs from not only its efficacy but also mode action. Here we show -...
Cilia and flagella associated protein 410 (CFAP410) is a localized at the basal body of cilia/flagella plays essential roles in ciliogenesis. Multiple single amino acid mutations CFAP410 have been identified patients. However, molecular mechanism for how cause these disorders remains poorly understood due to lack high-resolution structures protein. Our studies demonstrate that adopts bimodular architecture. We previously reported our structural on C-terminal domain (CTD) from various...
Exocytosis is an active vesicle trafficking process by which eukaryotes secrete materials to the extracellular environment and insert membrane proteins into plasma membrane. The final step of exocytosis in yeast involves assembly two t-SNAREs, Sso1/2 Sec9, with v-SNARE, Snc1/2, on secretory vesicles. rate-limiting this formation a binary complex t-SNAREs. Despite previous report acceleration Sec3, it remains unknown how Sso2 efficiently recruited vesicle-docking site marked Sec3. Here, we...
Cilia are antenna-like organelles protruding from the surface of many cell types in human body. Defects ciliary structure or function often lead to diseases that collectively called ciliopathies. and flagella-associated protein 410 (CFAP410) localizes at basal body cilia/flagella plays essential roles ciliogenesis, neuronal development DNA damage repair. It remains unknown how its specific location is achieved. Multiple single amino acid mutations CFAP410 have been identified patients with...
The exocyst is an evolutionarily conserved protein complex tethering secretory vesicles before their docking and fusion with the plasma membrane. also plays important roles in cell migration, synaptogenesis, neurite outgrowth. One of its subunits, Sec8, was reported to interact two major synaptic scaffolding proteins SAP102 PSD-95 that share high sequence homology contain three PDZ domains at N-terminal region. interaction via binding C-terminal ITTV motif Sec8 proteins. However, it remains...
Abstract Cilia are antenna-like organelles protruding from the surface of many cell types in human body. Defects ciliary structure or function often lead to diseases that collectively called ciliopathies. and flagella associated protein 410 (CFAP410) localizes at basal body cilia/flagella plays essential roles ciliogenesis, neuronal development, DNA damage repair. It remains unknown how its specific location is achieved. Multiple single amino acid mutations CFAP410 have been identified...
The exocyst is an evolutionarily conserved protein complex tethering secretory vesicles before their docking and fusion with the plasma membrane. also plays important roles in cell migration, synaptogenesis, neurite outgrowth. One of its subunits, Sec8, was reported to interact two major synaptic scaffolding proteins SAP102 PSD-95 that share high sequence homology contain three PDZ domains at N-terminal region. interaction via binding C-terminal ITTV motif Sec8 proteins. However, it remains...
Abstract Exocytosis is an active vesicle trafficking process by which eukaryotes secrete materials to the extracellular environment and insert membrane proteins into plasma membrane. The final step of exocytosis in yeast involves assembly two t-SNAREs, Sso1/2 Sec9, with v-SNARE, Snc1/2, on secretory vesicles. rate-limiting this formation a binary complex t-SNAREs. Despite previous report acceleration Sec3, it remains unknown how Sso2 efficiently recruited vesicle-docking site marked Sec3....
Abstract Cilia and flagella associated protein 410 (CFAP410) is a localized at the basal body of cilia/flagella plays essential roles in ciliogenesis. Multiple single amino acid mutations CFAP410 have been identified patients. However, molecular mechanism for how cause these disorders remains poorly understood due to lack high-resolution structures protein. Our studies demonstrate that adopts bimodular architecture. We previously reported our structural on C-terminal domain (CTD) from...