A5037053993- Telomeres, Telomerase, and Senescence
- RNA regulation and disease
- Spectroscopy Techniques in Biomedical and Chemical Research
- Date Palm Research Studies
- Skin Protection and Aging
- Lysosomal Storage Disorders Research
- Redox biology and oxidative stress
- Calcium signaling and nucleotide metabolism
- Molecular Biology Techniques and Applications
- Endoplasmic Reticulum Stress and Disease
- Mechanical Circulatory Support Devices
- melanin and skin pigmentation
- Signaling Pathways in Disease
- RNA modifications and cancer
- Spectroscopy and Chemometric Analyses
- RNA Research and Splicing
- Pluripotent Stem Cells Research
- Erythrocyte Function and Pathophysiology
BOKU University
2013-2024
Institute of Molecular Biotechnology
2019-2024
Austrian Cluster for Tissue Regeneration
2024
Christian Doppler Laboratory for Thermoelectricity
2013-2021
Evercyte (Austria)
2013
Modifications of ribosomal RNA expand the nucleotide repertoire and thereby contribute to ribosome heterogeneity translational regulation gene expression. One particular m5C modification 25S RNA, which is introduced by Rcm1p, was previously shown modulate stress responses lifespan in yeast other small organisms. Here, we report that NSUN5 functional orthologue introducing m5C3782 into human m5C3438 mouse 28S RNA. Haploinsufficiency fibroblasts from William Beuren syndrome patients causes...
Skin aging is driven by intrinsic and extrinsic factors impacting on skin functionality with progressive age. One factor of this multifaceted process cellular senescence, as it has recently been identified to contribute a declining tissue in old In the skin, senescent cells have found markedly accumulate age, thus might impact directly characteristics. Especially switch from young, extracellular matrix-building fibroblasts senescence-associated secretory phenotype (SASP) could alter...
Abstract Due to their high biological activity, thiosemicarbazones have been developed for treatment of diverse diseases, including cancer, resulting in multiple clinical trials especially the lead compound Triapine. During last years, a novel subclass anticancer has attracted substantial interest based on enhanced cytotoxic activity. Increasing evidence suggests that double-dimethylated Triapine derivative Me 2 NNMe differs from not only its efficacy but also mode action. Here we show -...