A5024636788- Skin Protection and Aging
- Telomeres, Telomerase, and Senescence
- Extracellular vesicles in disease
- Echinoderm biology and ecology
- Antioxidant Activity and Oxidative Stress
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- RNA Research and Splicing
- Sirtuins and Resveratrol in Medicine
- RNA Interference and Gene Delivery
- Antimicrobial Peptides and Activities
- Cholesterol and Lipid Metabolism
- Sulfur Compounds in Biology
- Adipose Tissue and Metabolism
- Influenza Virus Research Studies
- Respiratory viral infections research
- Eicosanoids and Hypertension Pharmacology
- Genetics, Aging, and Longevity in Model Organisms
- interferon and immune responses
- melanin and skin pigmentation
- Retinoids in leukemia and cellular processes
- Silk-based biomaterials and applications
- Pediatric health and respiratory diseases
- Circular RNAs in diseases
- Heavy Metal Exposure and Toxicity
Christian Doppler Laboratory for Thermoelectricity
2016-2023
BOKU University
2016-2023
Institute of Molecular Biotechnology
2023
Marinomed Biotech (Austria)
2010
Loss of functionality during aging cells and organisms is caused accompanied by altered cell-to-cell communication signalling. One factor thereby the chronic accumulation senescent concomitant senescence-associated secretory phenotype (SASP) that contributes to microenvironment remodelling a pro-inflammatory status. While protein based SASP factors have been well characterized, little known about small extracellular vesicles (sEVs) their miRNA cargo. Therefore, we analysed secretion sEVs...
The 2009 flu pandemic and the appearance of oseltamivir-resistant H1N1 influenza strains highlight need for treatment alternatives. One such option is creation a protective physical barrier in nasal cavity. In vitro tests demonstrated that iota-carrageenan potent inhibitor A virus infection, most importantly also H1N1/2009 vitro. Consequently, we tested commercially available spray containing an mouse infection model. Treatment mice infected with lethal dose PR8/34 starting up to 48 hours...
Skin aging is driven by intrinsic and extrinsic factors impacting on skin functionality with progressive age. One factor of this multifaceted process cellular senescence, as it has recently been identified to contribute a declining tissue in old In the skin, senescent cells have found markedly accumulate age, thus might impact directly characteristics. Especially switch from young, extracellular matrix-building fibroblasts senescence-associated secretory phenotype (SASP) could alter...
The common cold, the most prevalent contagious viral disease in humans still lacks a safe and effective antiviral treatment. Iota-Carrageenan is broadly active against respiratory viruses in-vitro has an excellent safety profile. This study investigated efficacy of nasal spray patients with cold symptoms. In randomized, double-blind, placebo-controlled exploratory trial, 35 human subjects suffering from early symptoms received (0.12%) saline solution three times daily for 4 days, compared to...
There is increasing evidence that senescent cells are a driving force behind many age-related pathologies and their selective elimination increases the life- healthspan of mice. Senescent negatively affect surrounding tissue by losing cell specific functionality secreting pro-tumorigenic pro-inflammatory mixture growth hormones, chemokines, cytokines proteases, termed senescence-associated secretory phenotype (SASP). Here we identified an extract from plant Solidago virgaurea subsp....
Extracellular vesicles (EVs) and their miRNA cargo are intercellular communicators transmitting pleiotropic messages between different cell types, tissues, body fluids. Recently, they have been reported to contribute skin homeostasis were identified as members of the senescence-associated secretory phenotype human dermal fibroblasts. However, role EV-miRNAs in paracrine signaling during aging is yet unclear. Here we provide evidence for existence small EVs interstitial fluid using open flow...
In the current study, we have extended previous findings aiming at a better understanding of molecular mechanisms underlying UVB-induced senescence diploid human dermal fibroblasts (HDFs), an experimental model to study process photoaging in skin. We provide evidence that inhibition proteasomal degradation damaged proteins and activation autophagosome formation are early events HDFs, dependent on accumulation reactive oxygen species. Our data suggest autophagy is required for establishment...
As an environmental poison, arsenic is responsible for many cancer deaths. Paradoxically, trioxide (ATO) presents also a powerful therapy used to treat refractory acute promyelocytic leukemia (APL) and intensively investigated treatment of other types. Noteworthy, frequently hampered by drug resistance, which often associated with enhancement tumor aggressiveness. In this study, we analyzed ATO-selected cells (A2780ATO) the mechanisms underlying their enhanced tumorigenicity These were...
The skin provides one of the most visual aging transformations in humans, and premature as a consequence oxidative stress DNA damage is frequently seen effect. Cells human are continuously exposed to endogenous exogenous damaging factors, which can cause all phases cell cycle. Increased levels and/or defective repair can, therefore, accelerate process lead age-related diseases like cancer. It not yet clear if enhanced activity factors could increase life or health span cells. In previous...