A5022836788- Microwave-Assisted Synthesis and Applications
- Multicomponent Synthesis of Heterocycles
- Chemical Synthesis and Analysis
- Synthesis and biological activity
- Catalytic Cross-Coupling Reactions
- Innovative Microfluidic and Catalytic Techniques Innovation
- Chemical Synthesis and Reactions
- Asymmetric Hydrogenation and Catalysis
- Nanomaterials for catalytic reactions
- Genetic and Kidney Cyst Diseases
- Microtubule and mitosis dynamics
- Asymmetric Synthesis and Catalysis
- Ionic liquids properties and applications
- Catalytic C–H Functionalization Methods
- Quinazolinone synthesis and applications
- Synthesis of Organic Compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Lipid metabolism and biosynthesis
- Wireless Power Transfer Systems
- Synthesis and Biological Evaluation
- Chemical synthesis and alkaloids
- Advanced DC-DC Converters
- Innovative Energy Harvesting Technologies
- Organic Chemistry Synthesis Methods
Medical University of Vienna
2022-2025
Max Perutz Labs
2022-2025
Vienna Biocenter
2022-2025
Anton Paar (Austria)
2007-2020
Coburg University of Applied Sciences
2019
University of Graz
2000-2009
Boehringer Ingelheim (Austria)
2008-2009
Anton Paar (Switzerland)
2006
Anton Proksch Institut
2006
Uppsala University
2004
Preface. Personal Foreword. 1. Introduction: Microwave Synthesis in Perspective. 1.1 and Medicinal Chemistry. 1.2 Microwave: Assisted Organic (MAOS) - A Brief History. 1.3 Scope Organization of the Book. 2. Theory. 2.1 Radiation. 2.2 Dielectric Heating. 2.3 Properties. 2.4 Versus Conventional Thermal 2.5 Effects. 2.5.1 Effects (Kinetics). 2.5.2 Specific 2.5.3 Non-Thermal (Athermal) 3. Equipment Review. 3.1 Introduction. 3.2 Domestic Ovens. 3.3 Dedicated Reactors for Synthesis. 3.4 Multimode...
The concept of automated sequential microwave-assisted library synthesis is introduced. For this purpose a dedicated single-mode microwave reactor with robotics interface including liquid handler and gripper was employed. allows dispensing reagents into the Teflon sealed reaction vials, while moves each vial in out cavity after irradiation. This technology employed for Biginelli three-component cyclocondensation reaction. A diverse set 17 CH-acidic-carbonyl compounds (1A-Q), 25 aldehydes...
The direct scalability of microwave-assisted organic synthesis (MAOS) in a prototype laboratory-scale multimode microwave batch reactor is investigated. Several different reactions have been scaled-up typically from 1 mmol to 100 scale. transformations include multicomponent chemistries (Biginelli dihydropyrimidine and Kindler thioamide synthesis), transition metal-catalyzed carbon−carbon cross-coupling protocols (Heck Negishi reactions), solid-phase synthesis, Diels−Alder cycloaddition...
An evaluation of a new bench-top microwave batch reactor that uses single 1 L reaction vessel is presented. Several microwave-assisted organic reactions have been scaled-up, including Newman Kwart and Diels–Alder reactions, Pd-catalyzed cross-couplings, heterocycle synthesis, aromatic substitution, Knoevenagel condensation. A range different solvents (high low absorbing), varying times (4 s up to 2 h), temperatures (120–250 °C) explored in these investigations. For all studied...
A newly designed robust and safe laboratory scale reactor for syntheses under sealed-vessel conditions at 250 °C maximum temperature 20 bar pressure is presented. The employs conductive heating of a sealed glass vessel via stainless steel jacket implements both online monitoring in addition to magnetic stirring. Reactions are performed 10 mL borosilicate vials that with silicone cap Teflon septum allow be on 2-6 scale. This conductively heated compared standard single-mode microwave...
Cilia and flagella associated protein 410 (CFAP410) is a localized at the basal body of cilia/flagella plays essential roles in ciliogenesis. Multiple single amino acid mutations CFAP410 have been identified patients. However, molecular mechanism for how cause these disorders remains poorly understood due to lack high-resolution structures protein. Our studies demonstrate that adopts bimodular architecture. We previously reported our structural on C-terminal domain (CTD) from various...
The microwave-mediated Biginelli dihydropyrimidine synthesis was reinvestigated using a purpose-built commercial microwave reactor with on-line temperature, pressure, and power control. Transformations carried out under heating at atmospheric pressure in ethanol solution show no rate or yield increase when the temperature is identical to conventional thermal heating. In case of superheating by irradiation observed increases are rationalized as consequence (kinetic) effect. Under sealed...
Abstract With the emergence of high-throughput screening in pharmaceutical industry over a decade ago, synthetic chemists were faced with challenge preparing large collections molecules to satisfy demand for new compounds. The unique exploratory power multicomponent reactions such as Biginelli three-component reaction was soon recognized be extremely valuable produce compound libraries time- and cost-effective manner. present review summarizes advances from our laboratories construction via...
Rapid, direct transition metal-catalyzed C-P(III) cross-coupling reactions were performed by microwave dielectric heating, employing diphenylphosphine and aryl halides/triflates as substrates. Depending on the specific halide/triflate precursor, highest yields obtained utilizing heterogeneous or homogeneous Pd Ni catalysts in DMF NMP presence of KOAc DABCO a base. [reaction: see text]
A 48 deep-well microtiter plate system for sealed vessel parallel microwave synthesis is described. The consists of a standard 6 × 8 matrix wells with maximum working volume 300 μL and made out strongly microwave-absorbing sintered silicon carbide. In combination an alumina sealing equipped adequate conical bore holes sample withdrawal, the setup can be used processing at temperatures up to ∼200 °C 20 bar pressure. displays excellent temperature reaction homogeneity was generation 30-member...
New rotor types using disposable glass vials for small-scale parallel synthesis in multimode microwave reactors are introduced. One comprises 16 groups of four vials, whereas the second uses silicon carbide plates with a 6 × 4 matrix to process vials. Both rotors achieve utmost temperature homogeneity upon irradiation and can be used microwave-mediated reactions at temperatures up 200 °C pressures 20 bar. The generation three different heterocycle libraries furnishing thiophenes, oxindoles,...
Abstract The copoly(2‐oxazoline) pNonOx 80 ‐ stat ‐pDc = Ox 20 can be synthesized from the cationic ring‐opening copolymerization of 2‐nonyl‐2‐oxazoline NonOx and 2‐dec‐9′‐enyl‐2‐oxazoline Dc in ionic liquid n ‐hexyl methylimidazolium tetrafluoroborate under microwave irradiation 250 g/batch quantities. polymer precipitates upon cooling, enabling easy recovery liquid. Both monomers obtained fatty acids renewable resources. used as a photoresist (resolution 1 μm) based on UV‐induced thiol–ene...
Abstract Terminal chelation‐controlled Heck vinylations of electron‐rich amino‐functionalized vinyl ethers were performed with high regioselectivity furnishing moderate to good isolated yields the corresponding 1‐alkoxy‐1,3‐butadienes. DFT calculations support an amine‐palladium(II) coordination strength reactivity/selectivity rationale, where dimethylamino group was preferred metal presenting functionality. Controlled microwave heating effectively accelerated these palladium‐catalyzed...
Cilia are antenna-like organelles protruding from the surface of many cell types in human body. Defects ciliary structure or function often lead to diseases that collectively called ciliopathies. and flagella-associated protein 410 (CFAP410) localizes at basal body cilia/flagella plays essential roles ciliogenesis, neuronal development DNA damage repair. It remains unknown how its specific location is achieved. Multiple single amino acid mutations CFAP410 have been identified patients with...