A5103149615- earthquake and tectonic studies
- Vascular Procedures and Complications
- Peripheral Artery Disease Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- Central Venous Catheters and Hemodialysis
- Geological and Geochemical Analysis
- Isotope Analysis in Ecology
- Methane Hydrates and Related Phenomena
- Antimicrobial Resistance in Staphylococcus
- Biliary and Gastrointestinal Fistulas
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Effects and risks of endocrine disrupting chemicals
- Seismology and Earthquake Studies
- Cellular transport and secretion
- Esophageal and GI Pathology
- Geology and Paleoclimatology Research
- Pancreatitis Pathology and Treatment
- Mycotoxins in Agriculture and Food
- Ubiquitin and proteasome pathways
- Congenital Diaphragmatic Hernia Studies
- RNA and protein synthesis mechanisms
- Gallbladder and Bile Duct Disorders
- Endoplasmic Reticulum Stress and Disease
Hokkaido University
2006-2025
Shibaura Institute of Technology
2025
Asahi General Hospital
2018-2024
University of Tokyo Hospital
2021-2022
Tohoku University
2016-2022
Kyowa Kirin (Japan)
2010-2022
Funabashi Municipal Medical Center
2000-2021
Setsunan University
2018
National Center for Global Health and Medicine
2016
Hakodate National Hospital
2014
The Nankai Trough accretionary prism is considered an “end‐member” accreting a coarse terrigenous sediment section in setting with structural simplicity, unparalleled resolution by seismic and other geophysical techniques, large historic earthquakes. It therefore has been the focus of Ocean Drilling Program (ODP) drilling to address several unresolved questions concerning processes evolution. At six sites cored along two transects across during ODP Leg 190, lithostratigraphy diagenesis vary...
This work was designed to clarify the absolute abundances of transporters and receptors at different cerebral regions blood–brain barriers (BBB) blood–spinal cord barrier (BSCB) in humans rats, using physiologically relevant units (pmol/g tissue fmol/cm2); 39 29 proteins including tight-junction markers were quantified human rat capillary samples, respectively. Protein expression levels almost all identical within a 2-fold range between BBB BSCB while many showed >2-fold smaller than humans....
The order Zoantharia (= Zoanthiniaria, Zoanthidea) remains one of the most taxonomically neglected anthozoan groups, primarily owing to difficulty examining internal morphology sand-encrusted zoanthids, upon which classification has been largely based until very recently. Additionally, relatively few zoanthid species (all belonging genus Epizoanthus) have properly described from deep-sea. Numerous individuals an unidentified sediment-encrusting zoanthid-like were observed and sampled during...
Protein crystallization remains one of the bottlenecks in crystallographic analysis macromolecules. An automated large-scale protein-crystallization system named PXS has been developed consisting following subsystems, which proceed parallel under unified control software: dispensing precipitants and protein solutions, sealing plates, carrying robot, incubators, observation image-storage server. A sitting-drop plate specialized for also designed developed. can set up 7680 drops vapour...
Research Article| November 01, 2009 Structural architecture and active deformation of the Nankai Accretionary Prism, Japan: Submersible survey results from Tenryu Submarine Canyon Kiichiro Kawamura; Kawamura † 1Fukada Geological Institute, 2-13-12 Honkomagome, Bunkyo, Tokyo 113-0021, Japan †E-mail: kichiro@fgi.or.jp Search for other works by this author on: GSW Google Scholar Yujiro Ogawa; Ogawa § 2Graduate School Life Environmental Sciences, University Tsukuba, 1-1-1 Tennodai, Tsukuba...
Violacein and the indolocarbazoles are naturally occurring bisindole products with various biological activities, including antitumor activity. Although these compounds have markedly different molecular skeletons, their biosynthetic pathways share same intermediate "compound X," which is produced from L-tryptophan via indole-3-pyruvic acid imine. Compound X a short-lived that spontaneously converted to chromopyrrolic for indolocarbazole biosynthesis, whereas VioE transforms compound into...
Compound-specific carbon isotope analysis of acetic acid is useful for origin discrimination and quality control vinegar. Intramolecular distributions, which are each ratios the methyl carboxyl carbons in molecule, may be required to obtain more detailed information discriminate such origin. In this study, improved gas chromatography–pyrolysis–gas chromatography–combustion–isotope ratio mass spectrometry (GC-Py-GC-C-IRMS) combined with headspace solid-phase microextraction (HS-SPME) was used...
The selective adsorption and separation of benzene from structurally similar six-membered hydrocarbons fluorocarbons remain a significant challenge due to their comparable physical properties. In this study, we investigated the molecular recognition properties perfluorinated triketonate Cu(II) complex (1) as Nonporous Adaptive Crystal (NAC). addition previously reported (2)-encapsulated crystal 1•(2)3, report here structures guest-free 1 cyclohexene (3)-encapsulated 1•(O)2•3, where (O)2...
ABSTRACT Introduction No consensus exists on the optimal surgical strategy for small bowel obstruction (SBO). Therefore, we assessed feasibility of laparoscopic surgery (LS) SBO by comparing LS and open (OS) outcomes. Methods We retrospectively analyzed 303 patients who underwent SBO. The characteristics 233 exploratory LS, including 43 conversion (OCS) 70 OS, were propensity score‐matched to compare Risk factors a predictive model OCS also investigated. Results After matching, had smaller...
Leg 190 of the Ocean Drilling Program yielded discoveries about early stages tectonic and sedimentary evolution a trench-slope basin in Nankai subduction zone southwest Japan. Lithofacies character, biostratigraphy, seismic-reflection data show that basin's architecture was constructed during Quaternary by frontal offscraping coarse-grained trench-wedge deposits. Clast types muddy gravel beds indicate one trench's polymictic sources enriched low-grade metasedimentary rocks. Outcrops Shimanto...
Acetic acid is the main ingredient of vinegar, and worth vinegar often depends on fermentation raw materials. In this study, we have developed a simple rapid method for discriminating materials by measuring hydrogen carbon isotope ratio acetic using head space solid-phase microextraction (HS-SPME) combined with gas chromatography−high temperature conversion or combustion-isotope mass spectrometry (GC-TC/C-IRMS). The measurement in was possible repeatabilities (1σ) ±5.0‰ ±0.4‰ carbon, which...
The purpose of this study was to determine absolute protein expression levels transporters at the porcine inner blood-retinal barrier (BRB) and compare transporter quantitatively among BRB, outer blood-brain (BBB), blood-cerebrospinal fluid (BCSFB). Crude membrane fractions isolated retinal capillaries (inner BRB) pigment epithelium (RPE, were prepared from eyeballs, while plasma brain (BBB) choroid plexus Protein 32 molecules, including 16 ATP-binding-cassette (ABC) 13 solute-carrier (SLC)...
MAP1LC3/LC3 (a mammalian ortholog family of yeast Atg8) is a ubiquitin-like protein that essential for autophagosome formation. LC3 conjugated to phosphatidylethanolamine on phagophores and ends up distributed both inside outside the membrane. One well-known functions as binding partner receptor proteins, which target polyubiquitinated organelles proteins phagophore through direct interaction with in selective autophagy, their LC3-binding ability degradation substances. Although number have...
The ATP-binding cassette (ABC) transporter A subfamily 8 (ABCA8) belongs to the ABCA6-like transporters subgroup, which is distinct from ABCA1-like subgroup in ABCA family. expression and function of short-size human ABCA8 lacking one two domains for ATP hydrolysis, are regularly present other transporters, have been reported. However, functional differences between full-size ABCA8, has domains, remain unknown. purpose study was clarify tissue profiles characteristics mouse human....
Abstract NK cells express FcγRIII (CD16), which is responsible for IgG-dependent cell cytotoxicity and production of several cytokines chemokines. Whereas on composed both FcγRIIIα FcRγ chains, that mast distinct from made FcγRIIIα, FcRβ, FcRγ. Mast show degranulation release mediators, cause anaphylactic responses upon cross-linking as well FcεRI with aggregated IgE. In this paper, we examined whether IgE activates through their surface. We found produce chemokines related to an allergic...
Mitochondrial μ-calpain and apoptosis-inducing factor (AIF)-dependent photoreceptor cell death has been seen in several rat mouse models of retinitis pigmentosa (RP). Previously, we demonstrated that the specific peptide inhibitor mitochondrial μ-calpain, Tat-µCL, protected against retinal degeneration following intravitreal injection or topical eye-drop application Mertk gene-mutated Royal College Surgeons rats, one animal RP. Because high rate rhodopsin mutations RP patients, present study...
We examined the process of seamount subduction via a numerical simulation using finite element method, applying frictional force on plate interface that is proportional to normal stress. calculate incremental stress due infinitesimal deformation associated with subduction, and consider implications for buildup fracturing itself. Our results show maximum shear concentrates at both flanks seamount, which suggests will start there. can surmise that, eventually, seaward flank may be more apt...
Abstract The selective phosphatidylinositol 3-kinase δ inhibitor zandelisib demonstrated favorable safety and efficacy [objective response rate (ORR) 79%] in patients with B-cell malignancies a phase 1b study the US Switzerland. In this 1 dose-escalation (NCT03985189), 9 Japanese relapsed/refractory indolent non-Hodgkin’s lymphoma (R/R iNHL) received on continuous daily schedule (45 or 60 mg) until progressive disease/unacceptable toxicity. No dose-limiting toxicities were observed. maximum...