A5007696346- Orthopaedic implants and arthroplasty
- Bone fractures and treatments
- Orthopedic Infections and Treatments
- Mesenchymal stem cell research
- Total Knee Arthroplasty Outcomes
- Adhesion, Friction, and Surface Interactions
- Periodontal Regeneration and Treatments
- Knee injuries and reconstruction techniques
- Injury Epidemiology and Prevention
- Virus-based gene therapy research
- Cervical and Thoracic Myelopathy
- Spinal Fractures and Fixation Techniques
- Diamond and Carbon-based Materials Research
- Muscle Physiology and Disorders
- Spine and Intervertebral Disc Pathology
- Sports injuries and prevention
- 3D Printing in Biomedical Research
- Tendon Structure and Treatment
- Bone health and osteoporosis research
- Winter Sports Injuries and Performance
- Pregnancy-related medical research
Stanford University
2012-2016
Stanford Medicine
2012-2013
Orthopaedic Research Laboratories
2012-2013
Abstract Wear particles generated with use of total joint replacements incite a chronic macrophage‐mediated inflammatory reaction, which leads to implant failure. Macrophage activation may be polarized into two states, an M1 proinflammatory state dominating alternatively activated M2 anti‐inflammatory state. We hypothesized that IL‐4, activator macrophages, could modulate polyethylene (PE) particle‐induced osteolysis in experimental murine model. Four animal groups included (a) calvarial...
Treatment of critical size bone defects is challenging. Recent studies showed that the cytokine stromal cell-derived factor 1 alpha (SDF-1α) has potential to improve regenerative effect low morphogenetic protein 2 (BMP-2) concentrations. The goal this study was demonstrate combined SDF-1α and BMP-2 on regeneration stem cell recruitment using a femoral defect model. A total 72 mice were randomized six groups. External fixators implanted onto right femur each mouse 3 mm created. Depending...
Associated with the trend towards increased health consciousness and fitness, triathlon has established itself as a sport for masses. The goals of this study were to evaluate injury risk factors non-professional triathletes compare prospective retrospective evaluation methods. Using an online survey, 212 retrospectively answered questionnaire about their training habits injuries during past 12 months. Forty-nine these participated in 12-month trial. Injuries classified regard anatomical...
Loss of proprioceptive function occurs after anterior cruciate ligament (ACL) rupture. Clinical, motor, and is known to improve ACL reconstruction but does not return normal. While histological studies human allografts have been unable demonstrate mechanoreceptor reinnervation, animal data suggest that reinnervation may occur when an autograft used.To compare the presence or absence mechanoreceptors between allograft versus in humans.Cohort study; Level evidence, 3.Ten patients with previous...
Abstract Aseptic loosening secondary to particle‐associated periprosthetic osteolysis remains a major cause of failure total joint replacements (TJR) in the mid‐ and long term. As sentinels innate immune system, macrophages are central recognition initiation inflammatory cascade, which results activation bone resorbing osteoclasts. Toll‐like receptors (TLRs) involved pathogen‐associated molecular patterns danger‐associated patterns. Experimentally, polymethylmethacrylate polyethylene (PE)...
Mesenchymal stromal cell (MSCs) are key cellular components for site-specific tissue regeneration. The chemokine derived factor 1 alpha (SDF-1α) is known to attract stem cells via the C-X-C receptor-4 (CXCR4) receptor. aim of study was develop a model attraction using SDF-1α overexpressing fat grafts. Murine MSCs were lentiviral transduced express genes enhanced green fluorescent protein, firefly luciferace, and human CXCR4 (hCXCR4). adenoviral red protein transgenes. cultured on transwells...
Objectives: Functional instability following anterior cruciate ligament (ACL) rupture is due to both loss of mechanical restraint, and proprioception that restricts the ability coordinated muscle activity compensate stabilize knee joint. This lack control thought be diminished or absent sensory feedback from ACL mechanoreceptors neuromuscular system. Clinical, motor proprioceptive function known improve reconstruction but does not return normal. While histological studies human allografts...
In contrast to spondylolisthesis of the lumbar spine, non-traumatic cervico-thoracic is a very rare lesion. Even minor changes in displacement vertebrae or cord can lead cervical myelopathy and paralysis. Since only few cases have been well-documented, there currently no clear preference between operative techniques.We describe case 63-year-old Caucasian man with 13 mm C7 T1. Within months, progressive developed as he began suffer pain loss function his digits was longer able walk...